PINK1 protects against cell death induced by mitochondrial depolarization, by phosphorylating Bcl-xL and impairing its pro-apoptotic cleavage.
PINK1 通过磷酸化 Bcl-xL 并抑制其促凋亡切割,从而保护细胞免受线粒体去极化引起的细胞死亡
期刊:Cell Death and Differentiation
影响因子:15.4
doi:10.1038/cdd.2013.19
Arena G, Gelmetti V, Torosantucci L, Vignone D, Lamorte G, De Rosa P, Cilia E, Jonas E A, Valente E M