日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The Alzheimer's therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia.

阿尔茨海默病治疗药物Lecanemab通过诱导小胶质细胞中的淀粉样蛋白清除程序来减轻Aβ病理。

Albertini Giulia, Zielonka Magdalena, Cuypers Marie-Lynn, Snellinx An, Xu Ciana, Poovathingal Suresh, Wojno Marta, Davie Kristofer, van Lieshout Veerle, Craessaerts Katleen, Wolfs Leen, Pasciuto Emanuela, Jaspers Tom, Horré Katrien, Serneels Lurgarde, Fiers Mark, Dewilde Maarten, De Strooper Bart

Bioenergetics and lipid metabolism in Alzheimer's disease: From cell biology to systemic health

阿尔茨海默病中的生物能量学和脂质代谢:从细胞生物学到系统健康

Maioli, Silvia; Nalvarte, Ivan; Ankarcrona, Maria; Schultzberg, Marianne; Zuloaga, Kristen L; Goikolea, Julen; Visser, Pieter Jelle; De Strooper, Bart; Winblad, Bengt; Pizzo, Paola; Williams, Pete A; Rodriguez-Rodriguez, Patricia; Naia, Luana

Phagocytes as plaque catalysts: Human macrophages generate seeding-competent Aβ42 fibrils with cross-seeding activity

吞噬细胞作为斑块催化剂:人巨噬细胞产生具有交叉播散活性的、可播散斑块的Aβ42原纤维

Konstantoulea, Katerina; Ramakers, Meine; Borrie, Sarah C; T'Syen, Dries; Moechars, Daan; Sliwinska, Malgorzata A; Pradhan, Brajabandhu; Albertini, Giulia; Baligács, Nóra; Tsaka, Grigoria; Houben, Bert; Fiers, Mark; Gallardo, Rodrigo; Dewilde, Maarten; Thal, Dietmar Rudolf; Willem, Michael; Neher, Jonas J; De Strooper, Bart; Rousseau, Frederic; Schymkowitz, Joost

Aβ plaques induce local pre-synaptic toxicity in human iPSC-derived neuron xenografts

Aβ斑块在人iPSC衍生神经元异种移植中诱导局部突触前毒性

van Vierbergen, Jacqueline Fréderique Maria; Calatayud, Carles; Balusu, Sriram; Carrano, Nicolò; Peredo, Nicolas; Vints, Katlijn; Gallego, Sandra Fernández; Horré, Katrien; De Strooper, Bart; Verstreken, Patrik

The chloride intracellular channel 1 (CLIC1) is essential for microglial morphodynamics and neuroinflammation.

氯离子细胞内通道 1 (CLIC1) 对小胶质细胞形态动力学和神经炎症至关重要。

Rifat Ali, Bickel Tom, Kreis Patricia, Trimbuch Thorsten, Onken Julia, Ivanov Andranik, Albertini Giulia, Beule Dieter, Mazzanti Michele, Singh Harpreet, Eickholt Britta J, De Strooper Bart, Geiger Jörg R P, Madry Christian

Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease.

Lecanemab 优先与阿尔茨海默病早期存在的较小聚集体结合

Fertan Emre, Lam Jeff Y L, Albertini Giulia, Dewilde Maarten, Wu Yunzhao, Akingbade Oluwatomi E S, Böken Dorothea, English Elizabeth A, De Strooper Bart, Klenerman David

Breaking Barriers: Delivering Therapeutics to the Brain in Alzheimer's Disease

突破障碍:将治疗药物输送到阿尔茨海默病患者的大脑

De Strooper, Bart; Scheltens, Philip; Salloway, Stephen

Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein.

通过与髓鞘少突胶质细胞糖蛋白(一种中枢神经系统特异性蛋白)的额外结合,延长抗体在大脑中的半衰期

Cuypers Marie-Lynn, Jaspers Tom, Clerckx Jarne, Leekens Simon, Cawthorne Christopher, Bormans Guy, Cleeren Frederik, Geukens Nick, De Strooper Bart, Dewilde Maarten

A proteogenomic tool uncovers protein markers for human microglial states

蛋白质基因组学工具揭示了人类小胶质细胞状态的蛋白质标志物

Haage, Verena; Bautista, Alex R; Tuddenham, John; Marshe, Victoria; Chiu, Rebecca; Liu, YunDuo; Lama, Tsering; Kelly, Shane S; Parghi, Neelang A; Park, Junho; Buonfiglioli, Alice; Furnari, Julia L; Haq, Imdadul; Pearse, Richard; Patel, Ronak; Terzioglu, Gizem; Touil, Hanane; Zeng, Lu; Noble, James; Sarkis, Rani A; Shneider, Neil A; de Witte, Lotje D; Schneider, Julie; Teich, Andrew; Young-Pearse, Tracy L; Riley, Claire; Bennett, David A; Canoll, Peter; Bruce, Jeffrey N; Howden, Andrew J M; Lloyd, Amy F; de Strooper, Bart; Sher, Falak; Sproul, Andrew A; Olah, Marta; Taga, Mariko; Zhang, Ya; Caisheng, Lu; Fujita, Masashi; Petyuk, Vladislav A; De Jager, Philip L

The curious case of a heterozygous loss-of-function PSEN1 variant associated with early-onset Alzheimer's disease

一个与早发性阿尔茨海默病相关的PSEN1杂合功能缺失变异体的奇特案例

Sanjuan-Ruiz, Inmaculada; Serneels, Lutgarde; Craessaerts, Katleen; Goate, Alison; Annaert, Wim; Chávez-Gutiérrez, Lucía; Shi, Yonggang; Sheikh-Bahaei, Nasim; Jen, Joanna C; Ramos, Eliana Marisa; Campan, Mihaela; Ward, Pamela M; Magaki, Shino; Bartlone, Kelly; Vinters, Harry V; Craig, David W; Ringman, John M; De Strooper, Bart