日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of a potent V3 glycan site broadly neutralizing antibody targeting an N332(gp120) glycan-independent epitope

鉴定出一种针对N332(gp120)糖基非依赖性表位的强效V3糖基位点广谱中和抗体

Gieselmann, Lutz; DeLaitsch, Andrew T; Rohde, Malena; Radford, Caelan; Worczinski, Johanna; Ashurov, Anna; Ahmadov, Elvin; Burger, Judith A; Havenar-Daughton, Colin; Deshpande, Sharvari; Giovannoni, Federico; Corti, Davide; Kreer, Christoph; Ercanoglu, Meryem Seda; Schommers, Philipp; Georgiev, Ivelin S; West, Anthony P Jr; Knüfer, Jacqueline; Stumpf, Ricarda; Kroidl, Arne; Geldmacher, Christof; Maganga, Lucas; William, Wiston; Ntinginya, Nyanda E; Hoelscher, Michael; Yang, Zhengrong; Wei, Qing; Renfrow, Matthew B; Green, Todd J; Novak, Jan; van Gils, Marit J; Gristick, Harry B; Gruell, Henning; Bloom, Jesse D; Seaman, Michael S; Bjorkman, Pamela J; Klein, Florian

Profiling of HIV-1 elite neutralizer cohort reveals a CD4bs bnAb for HIV-1 prevention and therapy.

HIV-1 精英中和抗体队列分析揭示了一种用于 HIV-1 预防和治疗的 CD4 结合位点广谱中和抗体。

Gieselmann Lutz, DeLaitsch Andrew T, Rohde Malena, Gruell Henning, Kreer Christoph, Ercanoglu Meryem Seda, Gristick Harry B, Schommers Philipp, Ahmadov Elvin, Radford Caelan, Mazzolini Andrea, Zhang Lily, West Anthony P Jr, Worczinski Johanna, Momot Anna, Reichwein Maren L, Knüfer Jacqueline, Stumpf Ricarda, Mkhize Nonhlanhla N, Kaldine Haajira, Bhebhe Sinethemba, Deshpande Sharvari, Giovannoni Federico, Stefanutti Erin, Benigni Fabio, Havenar-Daughton Colin, Corti Davide, Kroidl Arne, Adhikari Anurag, Nanfack Aubin J, Ambada Georgia E, Duerr Ralf, Maganga Lucas, William Wiston, Ntinginya Nyanda E, Wolf Timo, Geldmacher Christof, Hoelscher Michael, Lehmann Clara, Moore Penny L, Mora Thierry, Walczak Aleksandra M, Gilbert Peter B, Doria-Rose Nicole A, Huang Yunda, Bloom Jesse D, Seaman Michael S, Bjorkman Pamela J, Klein Florian

Consistent Induction of Broadly Neutralizing HIV Antibodies by a Novel Two-Step Mechanism Informs Immunogen Design

通过一种新型两步机制持续诱导广谱中和HIV抗体,为免疫原设计提供指导

Skelly, Ashwin N; Gristick, Harry B; Li, Hui; Gavor, Edem; Connell, Andrew J; Kreider, Edward F; Marchitto, Lorie; Hogarty, Michael P; Newby, Maddy L; Allen, Joel D; Liu, Weimin; West, Anthony P Jr; Ayyanathan, Kasirajan; Campion, Mary S; Winters, Kaitlyn; Gordon, Colette G; Osbaldeston, Rebecca A; Akeley, Macy J; Li, Yingying; Singh, Ajay; Cruickshank, Kendra; Park, Younghoon; Zhao, Chengyan; Li, Xuduo; Amereh, Khaled; Itallie, Elizabeth Van; Carey, John W; Albertus, Amie; DeLaitsch, Andrew T; Keeffe, Jennifer R; Lituchy, Melinda G; Walsh, Agnes A; Morris, Daniel J; Habib, Rumi; Bibollet-Ruche, Frederic; Mishra, Nitesh; Avillion, Gabriel; Koranda, Nicholas S; Plante, Samantha J; Martella, Christian L; Lora, Jinery; Wang, Eric J D; Lewis, Mark G; Martin, Malcolm A; Nussenzweig, Michel C; Seaman, Michael S; Irvine, Darrell J; Wiehe, Kevin J; Haynes, Barton F; Wagh, Kshitij; Korber, Bette T; Andrabi, Raiees; Crispin, Max; Weissman, Drew; Bjorkman, Pamela J; Hahn, Beatrice H; Shaw, George M

Profiling a large HIV-1 elite neutralizer cohort reveals remarkable CD4bs bNAb for HIV-1 prevention and therapy

对大量 HIV-1 精英中和抗体队列进行分析,揭示了用于 HIV-1 预防和治疗的显著 CD4 结合位点广谱中和抗体 (bNAb)。

Gieselmann, Lutz; DeLaitsch, Andrew T; Rohde, Malena; Gruell, Henning; Kreer, Christoph; Ercanoglu, Meryem Seda; Gristick, Harry B; Schommers, Philipp; Ahmadov, Elvin; Radford, Caelan; Mazzolini, Andrea; Zhang, Lily; West, Anthony P Jr; Worczinski, Johanna; Momot, Anna; Reichwein, Maren L; Knüfer, Jacqueline; Stumpf, Ricarda; Mkhize, Nonhlanhla N; Kaldine, Haajira; Bhebhe, Sinethemba; Deshpande, Sharvari; Giovannoni, Frederico; Stefanutti, Erin; Benigni, Fabio; Havenar-Daughton, Colin; Corti, Davide; Kroidl, Arne; Adhikari, Anurag; Nanfack, Aubin J; Ambada, Georgia E; Duerr, Ralf; Maganga, Lucas; William, Wiston; Ntinginya, Nyanda E; Wolf, Timo; Geldmacher, Christof; Hoelscher, Michael; Lehmann, Clara; Moore, Penny L; Mora, Thierry; Walczak, Aleksandra M; Gilbert, Peter B; Doria-Rose, Nicole A; Huang, Yunda; Bloom, Jesse D; Seaman, Michael S; Bjorkman, Pamela J; Klein, Florian

Identification of a broad and potent V3 glycan site bNAb targeting an N332(gp120) glycan-independent epitope

鉴定出一种靶向N332(gp120)糖基非依赖性表位的广谱高效V3糖基化位点bNAb

Gieselmann, Lutz; DeLaitsch, Andrew T; Rohde, Malena; Radford, Caelan; Worczinski, Johanna; Momot, Anna; Ahmadov, Elvin; Burger, Judith A; Havenar-Daughton, Colin; Deshpande, Sharvari; Giovannoni, Federico; Corti, Davide; Kreer, Christoph; Ercanoglu, Meryem Seda; Schommers, Philipp; Georgiev, Ivelin S; West, Anthony P Jr; Knüfer, Jacqueline; Stumpf, Ricarda; Kroidl, Arne; Geldmacher, Christof; Maganga, Lucas; William, Wiston; Ntinginya, Nyanda E; Hoelscher, Michael; Yang, Zhengrong; Wei, Qing; Renfrow, Matthew; Green, Todd J; Novak, Jan; van Gils, Marit J; Gristick, Harry B; Gruell, Henning; Bloom, Jesse D; Seaman, Michael S; Bjorkman, Pamela J; Klein, Florian

Neutralizing antibodies elicited in macaques recognize V3 residues on altered conformations of HIV-1 Env trimer

猕猴体内产生的中和抗体可识别HIV-1 Env三聚体构象改变上的V3残基。

DeLaitsch, Andrew T; Keeffe, Jennifer R; Gristick, Harry B; Lee, Juliet A; Ding, Wenge; Liu, Weimin; Skelly, Ashwin N; Shaw, George M; Hahn, Beatrice H; Björkman, Pamela J

Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer

免疫恒河猴诱导的中和抗体可识别封闭开放的 HIV-1 包膜三聚体上的 CD4 结合位点

Zhi Yang, Kim-Marie A Dam, Michael D Bridges, Magnus A G Hoffmann, Andrew T DeLaitsch, Harry B Gristick, Amelia Escolano, Rajeev Gautam, Malcolm A Martin, Michel C Nussenzweig, Wayne L Hubbell, Pamela J Bjorkman

Selective Recognition of Carbohydrate Antigens by Germline Antibodies Isolated from AID Knockout Mice

从AID基因敲除小鼠中分离的种系抗体对碳水化合物抗原的选择性识别

Andrew T DeLaitsch ,Jacey R Pridgen ,Avery Tytla ,Megan L Peach ,Rayleen Hu ,David W Farnsworth ,Aislinn K McMillan ,Natalie Flanagan ,J Sebastian Temme ,Marc C Nicklaus ,Jeffrey C Gildersleeve

Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations

SARS-CoV-2 中和抗体的亲和力成熟赋予其效力、广度和对病毒逃逸突变的抵抗力

Frauke Muecksch, Yiska Weisblum, Christopher O Barnes, Fabian Schmidt, Dennis Schaefer-Babajew, Zijun Wang, Julio C C Lorenzi, Andrew I Flyak, Andrew T DeLaitsch, Kathryn E Huey-Tubman, Shurong Hou, Celia A Schiffer, Christian Gaebler, Justin Da Silva, Daniel Poston, Shlomo Finkin, Alice Cho, Meliss

Chemoenzymatic Synthesis of 9NHAc-GD2 Antigen to Overcome the Hydrolytic Instability of O-Acetylated-GD2 for Anticancer Conjugate Vaccine Development

利用化学酶法合成9NHAc-GD2抗原以克服O-乙酰化GD2的水解不稳定性,用于抗癌偶联疫苗的开发

Wu, Xuanjun; Ye, Jinfeng; DeLaitsch, Andrew T; Rashidijahanabad, Zahra; Lang, Shuyao; Kakeshpour, Tayeb; Zhao, Yuetao; Ramadan, Sherif; Saavedra, Paulo Vilar; Yuzbasiyan-Gurkan, Vilma; Kavunja, Herbert; Cao, Hongzhi; Gildersleeve, Jeffrey C; Huang, Xuefei