日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mechanism of action of compound-13: an α1-selective small molecule activator of AMPK

化合物 13 的作用机制:一种 α1 选择性小分子 AMPK 激活剂

Hunter, Roger W; Foretz, Marc; Bultot, Laurent; Fullerton, Morgan D; Deak, Maria; Ross, Fiona A; Hawley, Simon A; Shpiro, Natalia; Viollet, Benoit; Barron, Denis; Kemp, Bruce E; Steinberg, Gregory R; Hardie, D Grahame; Sakamoto, Kei

Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity

激酶抑制剂可阻止LRRK2毒性细胞和秀丽隐杆线虫模型中的神经退行性变。

Yao, Chen; Johnson, William M; Gao, Yue; Wang, Wen; Zhang, Jinwei; Deak, Maria; Alessi, Dario R; Zhu, Xiongwei; Mieyal, John J; Roder, Hanno; Wilson-Delfosse, Amy L; Chen, Shu G

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation.

SPAK/OSR1 调节 NKCC1 和 WNK 活性:分析 WNK 同工型相互作用和 T 环反式自磷酸化激活

Thastrup Jacob O, Rafiqi Fatema H, Vitari Alberto C, Pozo-Guisado Eulalia, Deak Maria, Mehellou Youcef, Alessi Dario R

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

PINK1 由线粒体膜电位去极化激活,并通过磷酸化丝氨酸 65 位点刺激 Parkin E3 连接酶活性。

Kondapalli, Chandana; Kazlauskaite, Agne; Zhang, Ning; Woodroof, Helen I; Campbell, David G; Gourlay, Robert; Burchell, Lynn; Walden, Helen; Macartney, Thomas J; Deak, Maria; Knebel, Axel; Alessi, Dario R; Muqit, Miratul M K

TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

TTBK2激酶底物特异性以及脊髓小脑性共济失调致病突变对其表达、活性、定位和发育的影响

Bouskila, Michale; Esoof, Noor; Gay, Laurie; Fang, Emily H; Deak, Maria; Begley, Michael J; Cantley, Lewis C; Prescott, Alan; Storey, Kate G; Alessi, Dario R

Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways

SPAK-OSR1依赖性和非依赖性途径对NKCC2离子共转运蛋白的调控

Richardson, Ciaran; Sakamoto, Kei; de los Heros, Paola; Deak, Maria; Campbell, David G; Prescott, Alan R; Alessi, Dario R

Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations

发现具有催化活性的帕金森病激酶PINK1的直系同源物:底物特异性分析及突变的影响

Woodroof, Helen I; Pogson, Joe H; Begley, Mike; Cantley, Lewis C; Deak, Maria; Campbell, David G; van Aalten, Daan M F; Whitworth, Alexander J; Alessi, Dario R; Muqit, Miratul M K

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization.

14-3-3 与 LRRK2 的结合受到多种帕金森病相关突变的破坏,并调节细胞质定位

Nichols R Jeremy, Dzamko Nicolas, Morrice Nicholas A, Campbell David G, Deak Maria, Ordureau Alban, Macartney Thomas, Tong Youren, Shen Jie, Prescott Alan R, Alessi Dario R

Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS

利用前体离子扫描质谱法鉴定MSK1中的新型磷酸化位点

McCoy, Claire E; macdonald, Andrew; Morrice, Nick A; Campbell, David G; Deak, Maria; Toth, Rachel; McIlrath, Joanne; Arthur, J Simon C

The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation

AMPK相关激酶的泛素结合结构域调控其构象以及LKB1介导的磷酸化和激活。

Jaleel, Mahaboobi; Villa, Fabrizio; Deak, Maria; Toth, Rachel; Prescott, Alan R; Van Aalten, Daan M F; Alessi, Dario R