日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation

对α-突触核蛋白原纤维形成过程中动力学捕获的有毒寡聚体进行结构表征

Chen, Serene W; Drakulic, Srdja; Deas, Emma; Ouberai, Myriam; Aprile, Francesco A; Arranz, Rocío; Ness, Samuel; Roodveldt, Cintia; Guilliams, Tim; De-Genst, Erwin J; Klenerman, David; Wood, Nicholas W; Knowles, Tuomas P J; Alfonso, Carlos; Rivas, Germán; Abramov, Andrey Y; Valpuesta, José María; Dobson, Christopher M; Cremades, Nunilo

Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease.

在 PINK1 帕金森病模型中,增强核苷酸代谢可防止线粒体功能障碍和神经退行性变

Tufi Roberta, Gandhi Sonia, de Castro Inês P, Lehmann Susann, Angelova Plamena R, Dinsdale David, Deas Emma, Plun-Favreau Hélène, Nicotera Pierluigi, Abramov Andrey Y, Willis Anne E, Mallucci Giovanna R, Loh Samantha H Y, Martins L Miguel

PINK1 deficiency in β-cells increases basal insulin secretion and improves glucose tolerance in mice

小鼠β细胞中PINK1缺陷可增加基础胰岛素分泌并改善葡萄糖耐量。

Deas, Emma; Piipari, Kaisa; Machhada, Asif; Li, Abi; Gutierrez-del-Arroyo, Ana; Withers, Dominic J; Wood, Nicholas W; Abramov, Andrey Y

Loss of PINK1 increases the heart's vulnerability to ischemia-reperfusion injury

PINK1 的缺失会增加心脏对缺血再灌注损伤的易感性。

Siddall, Hilary K; Yellon, Derek M; Ong, Sang-Bing; Mukherjee, Uma A; Burke, Niall; Hall, Andrew R; Angelova, Plamena R; Ludtmann, Marthe H R; Deas, Emma; Davidson, Sean M; Mocanu, Mihaela M; Hausenloy, Derek J

PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death

PINK1相关帕金森病是由神经元对钙诱导细胞死亡的易感性引起的。

Gandhi, Sonia; Wood-Kaczmar, Alison; Yao, Zhi; Plun-Favreau, Helene; Deas, Emma; Klupsch, Kristina; Downward, Julian; Latchman, David S; Tabrizi, Sarah J; Wood, Nicholas W; Duchen, Michael R; Abramov, Andrey Y

PINK1 function in health and disease

PINK1 在健康和疾病中的作用

Deas, Emma; Plun-Favreau, Helene; Wood, Nicholas W