日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Biomarker and pharmacodynamic activity of the transforming growth factor-beta (TGFβ) inhibitor SAR439459 as monotherapy and in combination with cemiplimab in a phase I clinical study in patients with advanced solid tumors

转化生长因子-β (TGFβ) 抑制剂 SAR439459 作为单一疗法和与 cemiplimab 联合治疗晚期实体肿瘤患者的 I 期临床研究的生物标志物和药效学活性

Debbie Robbrecht, Jean-Jacques Grob, Oliver Bechter, Matteo Simonelli, Bernard Doger, Ivan Borbath, Marcus O Butler, Tina Cheng, Patricia Martin Romano, Elvire Pons-Tostivint, Massimo Di Nicola, Giuseppe Curigliano, Min-Hee Ryu, Alejo Rodriguez-Vida, Dirk Schadendorf, Elena Garralda, Giovanni Abbade

Bexmarilimab-induced macrophage activation leads to treatment benefit in solid tumors: The phase I/II first-in-human MATINS trial

Bexmarilimab 诱导的巨噬细胞活化可使实体肿瘤的治疗获益:I/II 期首次人体 MATINS 试验

Jenna H Rannikko, Loic Verlingue, Maria de Miguel, Annika Pasanen, Debbie Robbrecht, Tanja Skytta, Sanna Iivanainen, Shishir Shetty, Yuk Ting Ma, Donna M Graham, Sukeshi Patel Arora, Panu Jaakkola, Christina Yap, Yujuan Xiang, Jami Mandelin, Matti K Karvonen, Juho Jalkanen, Sinem Karaman, Jussi P Ko

First-in-human phase 1 dose-escalation study of CAN04, a first-in-class interleukin-1 receptor accessory protein (IL1RAP) antibody in patients with solid tumours

针对实体瘤患者的首个白细胞介素-1 受体辅助蛋白 (IL1RAP) 抗体 CAN04 的 1 期人体首次剂量递增研究

Debbie Robbrecht, Christiane Jungels, Morten Mau Sorensen, Iben Spanggaard, Ferry Eskens, Signe Ø Fretland, Tormod Kyrre Guren, Philippe Aftimos, David Liberg, Christer Svedman, Lars Thorsson, Neeltje Steeghs, Ahmad Awada

Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical Trial

系统性阻断Clever-1可诱导实体瘤患者淋巴细胞活化并伴有免疫检查点分子下调:一项I/II期临床试验的结果

Reetta Virtakoivu # ,Jenna H Rannikko # ,Miro Viitala # ,Felix Vaura ,Akira Takeda ,Tapio Lönnberg ,Jussi Koivunen ,Panu Jaakkola ,Annika Pasanen ,Shishir Shetty ,Maja J A de Jonge ,Debbie Robbrecht ,Yuk Ting Ma ,Tanja Skyttä ,Anna Minchom ,Sirpa Jalkanen ,Matti K Karvonen ,Jami Mandelin ,Petri Bono ,Maija Hollmén