JAK2 Disease-Risk Variants Are Gain of Function and JAK Signaling Threshold Determines Innate Receptor-Induced Proinflammatory Cytokine Secretion in Macrophages

JAK2 疾病风险变异是功能的获得，而 JAK 信号阈值决定了巨噬细胞中先天受体诱导的促炎细胞因子分泌