日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Novel Co-Culture Model Reveals Enhanced CFTR Rescue in Primary Cystic Fibrosis Airway Epithelial Cultures with Persistent Pseudomonas aeruginosa Infection

一种新型共培养模型揭示了在持续性铜绿假单胞菌感染的原发性囊性纤维化气道上皮培养物中增强的 CFTR 拯救

Deborah M Cholon, Matthew A Greenwald, Matthew G Higgs, Nancy L Quinney, Susan E Boyles, Suzanne L Meinig, John T Minges, Ashlesha Chaubal, Robert Tarran, Carla M P Ribeiro, Matthew C Wolfgang, Martina Gentzsch

Small-molecule eRF3a degraders rescue CFTR nonsense mutations by promoting premature termination codon readthrough

小分子 eRF3a 降解剂通过促进提前终止密码子读通来挽救 CFTR 无义突变

Rhianna E Lee, Catherine A Lewis, Lihua He, Emily C Bulik-Sullivan, Samuel C Gallant, Teresa M Mascenik, Hong Dang, Deborah M Cholon, Martina Gentzsch, Lisa C Morton, John T Minges, Jonathan W Theile, Neil A Castle, Michael R Knowles, Adam J Kimple, Scott H Randell

A small-molecule inhibitor and degrader of the RNF5 ubiquitin ligase

RNF5 泛素连接酶的小分子抑制剂和降解剂

Jingjing Ruan, Dongdong Liang, Wenjing Yan, Yongwang Zhong, Daniel C Talley, Ganesha Rai, Dingyin Tao, Christopher A LeClair, Anton Simeonov, Yinghua Zhang, Feihu Chen, Nancy L Quinney, Susan E Boyles, Deborah M Cholon, Martina Gentzsch, Mark J Henderson, Fengtian Xue, Shengyun Fang

Airway Epithelial Inflammation In Vitro Augments the Rescue of Mutant CFTR by Current CFTR Modulator Therapies

体外气道上皮炎症增强了当前 CFTR 调节剂疗法对突变 CFTR 的挽救作用

Martina Gentzsch, Deborah M Cholon, Nancy L Quinney, Mary E B Martino, John T Minges, Susan E Boyles, Tara N Guhr Lee, Charles R Esther Jr, Carla M P Ribeiro

DNAJB12 and Hsp70 triage arrested intermediates of N1303K-CFTR for endoplasmic reticulum-associated autophagy

DNAJB12 和 Hsp70 分类阻断 N1303K-CFTR 中间体,用于内质网相关自噬

Lihua He, Andrew S Kennedy, Scott Houck, Andrei Aleksandrov, Nancy L Quinney, Alexandra Cyr-Scully, Deborah M Cholon, Martina Gentzsch, Scott H Randell, Hong Yu Ren, Douglas M Cyr

Accumulation and persistence of ivacaftor in airway epithelia with prolonged treatment

长期治疗会导致伊伐卡托在气道上皮中蓄积并持续存在

Tara N Guhr Lee, Deborah M Cholon, Nancy L Quinney, Martina Gentzsch, Charles R Esther

Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity

生物活性胸腺肽α-1不影响F508del-CFTR的成熟和活性

Andrea Armirotti, Valeria Tomati, Elizabeth Matthes, Guido Veit, Deborah M Cholon, Puay-Wah Phuan, Clarissa Braccia, Daniela Guidone, Martina Gentzsch, Gergely L Lukacs, Alan S Verkman, Luis J V Galietta, John W Hanrahan, Nicoletta Pedemonte

Potentiator ivacaftor abrogates pharmacological correction of ΔF508 CFTR in cystic fibrosis

增效剂ivacaftor可消除囊性纤维化中ΔF508 CFTR的药理学校正

Deborah M Cholon, Nancy L Quinney, M Leslie Fulcher, Charles R Esther Jr, Jhuma Das, Nikolay V Dokholyan, Scott H Randell, Richard C Boucher, Martina Gentzsch

Passive immunization with a polyclonal antiserum to the hemoglobin receptor of Haemophilus ducreyi confers protection against a homologous challenge in the experimental swine model of chancroid

使用杜克雷嗜血杆菌血红蛋白受体多克隆抗血清进行被动免疫,可在实验性软下疳猪模型中提供针对同源攻击的保护

Isabelle Leduc, William G Fusco, Neelima Choudhary, Patty A Routh, Deborah M Cholon, Marcia M Hobbs, Glen W Almond, Paul E Orndorff, Christopher Elkins

Modulation of endocytic trafficking and apical stability of CFTR in primary human airway epithelial cultures

CFTR在原代人呼吸道上皮细胞培养物中的内吞运输和顶端稳定性调控

Deborah M Cholon ,Wanda K O'Neal, Scott H Randell, John R Riordan, Martina Gentzsch