Declan F相关文献与解析，生知库 | 链接生命科学的每一步

Intestinal epithelial PTPN2 limits pathobiont colonization by immune-directed antimicrobial responses

肠道上皮细胞PTPN2通过免疫介导的抗菌反应限制病原菌的定植。

doi:10.1080/19490976.2025.2559029

Chatterjee, Pritha; Spalinger, Marianne R; Acevedo, Charly; Santos, Alina N; Gries, Casey M; Manz, Salomon M; Canale, Vinicius; Shawki, Ali; Sayoc-Becerra, Anica; Lei, Hillmin; Crawford, Meli'sa S; Eckmann, Lars; Borneman, James; McCole, Declan F

The PTPN2 rs1893217 IBD risk allele increases susceptibility to AIEC invasion by a JAK-STAT-CEACAM6 axis.

PTPN2 rs1893217 IBD 风险等位基因通过 JAK-STAT-CEACAM6 轴增加 AIEC 侵袭的易感性

期刊:Gut Microbes

影响因子:11

doi:10.1080/19490976.2025.2526136

Chatterjee Pritha, Canale Vinicius, King Stephanie J, Shawki Ali, Lei Hillmin, Santos Alina N, Haddad Michael, Gries Casey, McGovern Dermot P B, Borneman James, McCole Declan F

Tofacitinib Mitigates the Increased SARS-CoV-2 Infection Susceptibility Caused by an IBD Risk Variant in the PTPN2 Gene.

托法替尼可减轻由 PTPN2 基因中的 IBD 风险变异引起的 SARS-CoV-2 感染易感性增加

期刊:Cellular and Molecular Gastroenterology and Hepatology

影响因子:7.4

doi:10.1016/j.jcmgh.2024.101447

Spalinger Marianne R, Sanati Golshid, Chatterjee Pritha, Hai Rong, Li Jiang, Santos Alina N, Nordgren Tara M, Tremblay Michel L, Eckmann Lars, Hanson Elaine, Scharl Michael, Wu Xiwei, Boland Brigid S, McCole Declan F

新冠

发表日期：2025

文献求助收藏

PTPN2 Regulates Iron Handling Protein Expression in Inflammatory Bowel Disease Patients and Prevents Iron Deficiency in Mice.

PTPN2 调节炎症性肠病患者体内铁处理蛋白的表达，并预防小鼠缺铁

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms26073356

Lei Hillmin, Shawki Ali, Santos Alina N, Canale Vinicius, Manz Salomon, Crawford Meli'sa S, Chatterjee Pritha, Spalinger Marianne R, Scharl Michael, McCole Declan F

Respiratory Exposure to Agriculture Dust Extract Alters Gut Commensal Species and Key Metabolites in Mice

呼吸道暴露于农业粉尘提取物会改变小鼠肠道共生菌群及其关键代谢物

期刊:Journal of Applied Toxicology

影响因子:2.8

doi:10.1002/jat.4808

Crawford, Meli'sa S; Ulu, Arzu; Ramirez, Briana M; Santos, Alina N; Chatterjee, Pritha; Canale, Vinicius; Manz, Salomon; Lei, Hillmin; Soriano, Sarah Mae; Nordgren, Tara M; McCole, Declan F

Brewing a Cure: Engineering Yeast to Reduce Inflammation-Driven Tumors

酿造治愈良方：改造酵母以减少炎症驱动的肿瘤

期刊:Digestive Diseases and Sciences

影响因子:2.5

doi:10.1007/s10620-025-09194-6

Immunology/Inflammation

Yeast

发表日期：2025

文献求助收藏

Human mesenchymal stromal cells inhibit Mycobacterium avium replication in clinically relevant models of lung infection

人骨髓间充质干细胞在临床相关的肺部感染模型中抑制鸟分枝杆菌的复制

期刊:Thorax

影响因子:7.7

doi:10.1136/thorax-2023-220819

Shaw, Timothy D; Krasnodembskaya, Anna D; Schroeder, Gunnar N; Doherty, Declan F; Silva, Johnatas Dutra; Tandel, Shikha M; Su, Yue; Butler, David; Ingram, Rebecca J; O'Kane, Cecilia M

Respiratory exposure to agricultural dust extract promotes increased intestinal Tnfα expression, gut barrier dysfunction, and endotoxemia in mice

呼吸道接触农业粉尘提取物可促进小鼠肠道 Tnfα 表达增加、肠道屏障功能障碍和内毒血症

期刊:American Journal of Physiology-Gastrointestinal and Liver Physiology

影响因子:3.9

doi:10.1152/ajpgi.00297.2022

Meli'sa S Crawford, Arzu Ulu, Briana M Ramirez, Alina N Santos, Pritha Chatterjee, Vinicius Canale, Salomon Manz, Hillmin Lei, Tara M Nordgren, Declan F McCole

Mesenchymal stromal cells reduce inflammation and improve lung function in a mouse model of cystic fibrosis lung disease

间充质基质细胞可减轻囊性纤维化肺病小鼠模型的炎症并改善肺功能

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-024-81276-3

Declan F Doherty, Lydia E Roets, Caoifa M Dougan, Ryan R Brown, Ian J Hawthorne, Cecilia O'Kane, Anna D Krasnodembskaya, Marcus A Mall, Clifford C Taggart, Sinéad Weldon

免疫

细胞生物学

基质细胞

Immunology/Inflammation

Mouse

发表日期：2024

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Goblet of fire: how Chlamydia ignites region-specific colitis by hijacking goblet cells

火之杯：衣原体如何通过劫持杯状细胞引发区域特异性结肠炎

Intestinal epithelial PTPN2 limits pathobiont colonization by immune-directed antimicrobial responses

肠道上皮细胞PTPN2通过免疫介导的抗菌反应限制病原菌的定植。

The PTPN2 rs1893217 IBD risk allele increases susceptibility to AIEC invasion by a JAK-STAT-CEACAM6 axis.

PTPN2 rs1893217 IBD 风险等位基因通过 JAK-STAT-CEACAM6 轴增加 AIEC 侵袭的易感性

Tofacitinib Mitigates the Increased SARS-CoV-2 Infection Susceptibility Caused by an IBD Risk Variant in the PTPN2 Gene.

托法替尼可减轻由 PTPN2 基因中的 IBD 风险变异引起的 SARS-CoV-2 感染易感性增加

PTPN2 Regulates Iron Handling Protein Expression in Inflammatory Bowel Disease Patients and Prevents Iron Deficiency in Mice.

PTPN2 调节炎症性肠病患者体内铁处理蛋白的表达，并预防小鼠缺铁

Respiratory Exposure to Agriculture Dust Extract Alters Gut Commensal Species and Key Metabolites in Mice

呼吸道暴露于农业粉尘提取物会改变小鼠肠道共生菌群及其关键代谢物

Brewing a Cure: Engineering Yeast to Reduce Inflammation-Driven Tumors

酿造治愈良方：改造酵母以减少炎症驱动的肿瘤

Human mesenchymal stromal cells inhibit Mycobacterium avium replication in clinically relevant models of lung infection

人骨髓间充质干细胞在临床相关的肺部感染模型中抑制鸟分枝杆菌的复制

Respiratory exposure to agricultural dust extract promotes increased intestinal Tnfα expression, gut barrier dysfunction, and endotoxemia in mice

呼吸道接触农业粉尘提取物可促进小鼠肠道 Tnfα 表达增加、肠道屏障功能障碍和内毒血症

Mesenchymal stromal cells reduce inflammation and improve lung function in a mouse model of cystic fibrosis lung disease

间充质基质细胞可减轻囊性纤维化肺病小鼠模型的炎症并改善肺功能