日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy

RNA结合缺陷的TDP-43蛋白会导致TDP-43蛋白病小鼠模型的认知能力下降。

Julie C Necarsulmer ,Jeremy M Simon ,Baggio A Evangelista ,Youjun Chen ,Xu Tian ,Sara Nafees ,Ariana B Marquez ,Huijun Jiang ,Ping Wang ,Deepa Ajit ,Viktoriya D Nikolova ,Kathryn M Harper ,J Ashley Ezzell ,Feng-Chang Lin ,Adriana S Beltran ,Sheryl S Moy ,Todd J Cohen

Pathogenic SPTBN1 variants cause an autosomal dominant neurodevelopmental syndrome

致病性SPTBN1变异会导致常染色体显性遗传性神经发育综合征。

Margot A Cousin # ,Blake A Creighton # ,Keith A Breau ,Rebecca C Spillmann ,Erin Torti ,Sruthi Dontu ,Swarnendu Tripathi ,Deepa Ajit ,Reginald J Edwards ,Simone Afriyie ,Julia C Bay ,Kathryn M Harper ,Alvaro A Beltran ,Lorena J Munoz ,Liset Falcon Rodriguez ,Michael C Stankewich ,Richard E Person ,Yue Si ,Elizabeth A Normand ,Amy Blevins ,Alison S May ,Louise Bier ,Vimla Aggarwal ,Grazia M S Mancini ,Marjon A van Slegtenhorst ,Kirsten Cremer ,Jessica Becker ,Hartmut Engels ,Stefan Aretz ,Jennifer J MacKenzie ,Eva Brilstra ,Koen L I van Gassen ,Richard H van Jaarsveld ,Renske Oegema ,Gretchen M Parsons ,Paul Mark ,Ingo Helbig ,Sarah E McKeown ,Robert Stratton ,Benjamin Cogne ,Bertrand Isidor ,Pilar Cacheiro ,Damian Smedley ,Helen V Firth ,Tatjana Bierhals ,Katja Kloth ,Deike Weiss ,Cecilia Fairley ,Joseph T Shieh ,Amy Kritzer ,Parul Jayakar ,Evangeline Kurtz-Nelson ,Raphael A Bernier ,Tianyun Wang ,Evan E Eichler ,Ingrid M B H van de Laar ,Allyn McConkie-Rosell ,Marie T McDonald ,Jennifer Kemppainen ,Brendan C Lanpher ,Laura E Schultz-Rogers ,Lauren B Gunderson ,Pavel N Pichurin ,Grace Yoon ,Michael Zech ,Robert Jech ,Juliane Winkelmann ,Michael T Zimmermann ,Brenda Temple ,Sheryl S Moy ,Eric W Klee ,Queenie K-G Tan ,Damaris N Lorenzo

Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A

巨型锚蛋白-B介导轴突导向和侧枝修剪因子sema 3A的信号转导

Blake A Creighton # ,Simone Afriyie # ,Deepa Ajit ,Cristine R Casingal ,Kayleigh M Voos ,Joan Reger ,April M Burch ,Eric Dyne ,Julia Bay ,Jeffrey K Huang ,E S Anton ,Meng-Meng Fu ,Damaris N Lorenzo

An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline

HDAC6依赖性监视机制抑制tau蛋白介导的神经退行性变和认知衰退

Hanna Trzeciakiewicz,Deepa Ajit,Jui-Heng Tseng,Youjun Chen,Aditi Ajit,Zarin Tabassum,Rebecca Lobrovich,Claire Peterson,Natallia V Riddick,Michelle S Itano,Ashutosh Tripathy,Sheryl S Moy,Virginia M Y Lee,John Q Trojanowski,David J Irwin,Todd J Cohen

A unique tau conformation generated by an acetylation-mimic substitution modulates P301S-dependent tau pathology and hyperphosphorylation

一种由乙酰化模拟取代产生的独特tau蛋白构象可调节P301S依赖性tau蛋白病理和过度磷酸化。

Deepa Ajit,Hanna Trzeciakiewicz,Jui-Heng Tseng,Connor M Wander,Youjun Chen,Aditi Ajit,Diamond P King,Todd J Cohen

Phytochemicals and botanical extracts regulate NF-κB and Nrf2/ARE reporter activities in DI TNC1 astrocytes

植物化学物质和植物提取物调节 DI TNC1 星形胶质细胞中的 NF-κB 和 Nrf2/ARE 报告基因活性

Deepa Ajit, Agnes Simonyi, Runting Li, Zihong Chen, Mark Hannink, Kevin L Fritsche, Valeri V Mossine, Robert E Smith, Thomas K Dobbs, Rensheng Luo, William R Folk, Zezong Gu, Dennis B Lubahn, Gary A Weisman, Grace Y Sun

Up-regulation and activation of the P2Y(2) nucleotide receptor mediate neurite extension in IL-1β-treated mouse primary cortical neurons

P2Y(2)核苷酸受体的上调和激活介导IL-1β处理的小鼠原代皮质神经元的神经突延伸

Troy S Peterson, Christina N Thebeau, Deepa Ajit, Jean M Camden, Lucas T Woods, W Gibson Wood, Michael J Petris, Grace Y Sun, Laurie Erb, Gary A Weisman

Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA₂-IIA expression in astrocytes and microglia

促炎细胞因子和脂多糖诱导细胞形态变化,并上调星形胶质细胞和小胶质细胞中的 ERK1/2、iNOS 和 sPLA₂-IIA 表达

Wenwen Sheng, Yijia Zong, Arwa Mohammad, Deepa Ajit, Jiankun Cui, Dongdong Han, Jennifer L Hamilton, Agnes Simonyi, Albert Y Sun, Zezong Gu, Jau-Shyong Hong, Gary A Weisman, Grace Y Sun