日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Expanding the cytokine receptor alphabet reprograms T cells into diverse states

扩展细胞因子受体库可将T细胞重编程为多种状态。

Yang Zhao ,Masato Ogishi ,Aastha Pal ,Leon L Su ,Pingdong Tao ,Hua Jiang ,Grayson E Rodriguez ,Xiaojing Chen ,Qinli Sun ,Lea Wenting Rysavy ,Sam Limsuwannarot ,Deepa Waghray ,Anusha Kalbasi ,K Christopher Garcia

IL-9 as a naturally orthogonal cytokine with optimal JAK/STAT signaling for engineered T cell therapy

IL-9 作为一种天然正交细胞因子,具有最佳的 JAK/STAT 信号通路活性,可用于工程化 T 细胞治疗。

Hua Jiang ,Sam Limsuwannarot ,Kayla R Kulhanek ,Aastha Pal ,Ossama Labiad ,Lea W Rysavy ,Ada Wong ,Leon Su ,Sarah Cavender ,Johnathon Soro ,Stefano Testa ,Heather Ogana ,Deepa Waghray ,Pingdong Tao ,Kevin M Jude ,Christopher S Seet ,Gay M Crooks ,Everett J Moding ,K Christopher Garcia ,Anusha Kalbasi

Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination

Wnt-Frizzled-LRP6 起始复合物的结构揭示了辅助受体识别的基础

Naotaka Tsutsumi, Sunhee Hwang, Deepa Waghray, Simon Hansen, Kevin M Jude, Nan Wang, Yi Miao, Caleb R Glassman, Nathanael A Caveney, Claudia Y Janda, Rami N Hannoush, K Christopher Garcia

Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1

Epstein-Barr 病毒编码的 G 蛋白偶联受体 BILF1 的组成活性和免疫调节特性的结构基础

Naotaka Tsutsumi, Qianhui Qu, Maša Mavri, Maibritt S Baggesen, Shoji Maeda, Deepa Waghray, Christian Berg, Brian K Kobilka, Mette M Rosenkilde, Georgios Skiniotis, K Christopher Garcia

Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling

利用标记辅助冷冻电镜技术解析的人类Frizzled5结构支持了经典Wnt信号传导的异二聚体机制。

Naotaka Tsutsumi ,Somnath Mukherjee ,Deepa Waghray ,Claudia Y Janda ,Kevin M Jude ,Yi Miao ,John S Burg ,Nanda Gowtham Aduri ,Anthony A Kossiakoff ,Cornelius Gati ,K Christopher Garcia

Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy

病毒 GPCR US28 可以对几乎无限结构退化的趋化因子激动剂作出反应,发出信号

Timothy F Miles #, Katja Spiess #, Kevin M Jude #, Naotaka Tsutsumi #, John S Burg #, Jessica R Ingram, Deepa Waghray, Gertrud M Hjorto, Olav Larsen, Hidde L Ploegh, Mette M Rosenkilde, K Christopher Garcia

An extracellular interactome of immunoglobulin and LRR proteins reveals receptor-ligand networks

免疫球蛋白和 LRR 蛋白的细胞外相互作用组揭示了受体-配体网络

Engin Özkan, Robert A Carrillo, Catharine L Eastman, Richard Weiszmann, Deepa Waghray, Karl G Johnson, Kai Zinn, Susan E Celniker, K Christopher Garcia

Structural basis of Wnt recognition by Frizzled

Frizzled 识别 Wnt 的结构基础

Claudia Y Janda, Deepa Waghray, Aron M Levin, Christoph Thomas, K Christopher Garcia