A novel CD3ε fusion receptor allows T cell engager use in TCR-less allogeneic CAR T cells to improve activity and prevent antigen escape
一种新型CD3ε融合受体使得T细胞衔接器能够应用于不含TCR的同种异体CAR-T细胞中,从而提高其活性并防止抗原逃逸。
期刊:Molecular Therapy
影响因子:12
doi:10.1016/j.ymthe.2025.05.030
Lu, Dan; Chu, Hui-Yi; Park, Soo; Landon, Mark; Tsuda, Masanao; Avramis, Earl; Dege, Carissa; Dailey, Thomas; Pan, Yijia; Hanok, Sandeep Kothapally; Denholtz, Matthew; Abujarour, Ramzey; Lee, Tom; Goulding, John; Hosking, Martin; Goodridge, Jodie; Peralta, Eigen; Valamehr, Bahram