Degen Jay L相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Fibrin(ogen) engagement of S. aureus promotes the host antimicrobial response and suppression of microbe dissemination following peritoneal infection

金黄色葡萄球菌与纤维蛋白（原）的结合可促进宿主的抗菌反应，并抑制腹膜感染后的微生物扩散。

期刊:PLoS Pathogens

影响因子:4.9

doi:10.1371/journal.ppat.1010227

Negrón, Oscar; Hur, Woosuk S; Prasad, Joni; Paul, David S; Rowe, Sarah E; Degen, Jay L; Abrahams, Sara R; Antoniak, Silvio; Conlon, Brian P; Bergmeier, Wolfgang; Hӧӧk, Magnus; Flick, Matthew J

发表日期：2022

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Host fibrinogen drives antimicrobial function in Staphylococcus aureus peritonitis through bacterial-mediated prothrombin activation

宿主纤维蛋白原通过细菌介导的凝血酶原激活作用，在金黄色葡萄球菌腹膜炎中发挥抗菌功能。

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2009837118

Prasad, Joni M; Negrón, Oscar; Du, Xinli; Mullins, Eric S; Palumbo, Joseph S; Gilbertie, Jessica M; Höök, Magnus; Grover, Steven P; Pawlinski, Rafal; Mackman, Nigel; Degen, Jay L; Flick, Matthew J

发表日期：2021

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Plasminogen Deficiency Delays the Onset and Protects from Demyelination and Paralysis in Autoimmune Neuroinflammatory Disease

纤溶酶原缺乏可延缓自身免疫性神经炎症疾病的发病，并保护机体免受脱髓鞘和瘫痪的侵害。

期刊:Journal of Neuroscience

doi:10.1523/JNEUROSCI.2932-15.2017

Shaw, Maureen A; Gao, Zhen; McElhinney, Kathryn E; Thornton, Sherry; Flick, Matthew J; Lane, Adam; Degen, Jay L; Ryu, Jae Kyu; Akassoglou, Katerina; Mullins, Eric S

免疫/内分泌

发表日期：2017

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Genetic diminution of circulating prothrombin ameliorates multiorgan pathologies in sickle cell disease mice.

基因手段降低循环凝血酶原水平可改善镰状细胞病小鼠的多器官病变

影响因子:23.1

doi:10.1182/blood-2015-01-625707

Arumugam Paritha I, Mullins Eric S, Shanmukhappa Shiva Kumar, Monia Brett P, Loberg Anastacia, Shaw Maureen A, Rizvi Tilat, Wansapura Janaka, Degen Jay L, Malik Punam

细胞生物学

发表日期：2015

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Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

血液凝固蛋白纤维蛋白原通过趋化因子释放和抗原呈递促进自身免疫和脱髓鞘。

期刊:Nature Communications

影响因子:15.7

doi:10.1038/ncomms9164

Ryu, Jae Kyu; Petersen, Mark A; Murray, Sara G; Baeten, Kim M; Meyer-Franke, Anke; Chan, Justin P; Vagena, Eirini; Bedard, Catherine; Machado, Michael R; Rios Coronado, Pamela E; Prod'homme, Thomas; Charo, Israel F; Lassmann, Hans; Degen, Jay L; Zamvil, Scott S; Akassoglou, Katerina

免疫/内分泌

发表日期：2015

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Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification

纤维蛋白溶解对于骨折修复和预防异位骨化至关重要。

期刊:Journal of Clinical Investigation

影响因子:13.6

doi:10.1172/JCI84059

Yuasa, Masato; Mignemi, Nicholas A; Nyman, Jeffry S; Duvall, Craig L; Schwartz, Herbert S; Okawa, Atsushi; Yoshii, Toshitaka; Bhattacharjee, Gourab; Zhao, Chenguang; Bible, Jesse E; Obremskey, William T; Flick, Matthew J; Degen, Jay L; Barnett, Joey V; Cates, Justin M M; Schoenecker, Jonathan G

发表日期：2015

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Plasminogen is a joint-specific positive or negative determinant of arthritis pathogenesis in mice

纤溶酶原是小鼠关节炎发病机制中关节特异性的正向或负向决定因素。

期刊:Arthritis & Rheumatology

影响因子:10.9

doi:10.1002/art.38402

Raghu, Harini; Jone, Alice; Cruz, Carolina; Rewerts, Cheryl L; Frederick, Malinda D; Thornton, Sherry; Degen, Jay L; Flick, Matthew J

发表日期：2014

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Genetic and pharmacological modifications of thrombin formation in apolipoprotein e-deficient mice determine atherosclerosis severity and atherothrombosis onset in a neutrophil-dependent manner

在载脂蛋白E缺陷小鼠中，凝血酶形成的遗传和药理学改变以中性粒细胞依赖的方式决定动脉粥样硬化的严重程度和动脉粥样硬化血栓形成的发生。

期刊:PLoS One

影响因子:2.6

doi:10.1371/journal.pone.0055784

Borissoff, Julian I; Otten, Jeroen J T; Heeneman, Sylvia; Leenders, Peter; van Oerle, René; Soehnlein, Oliver; Loubele, Sarah T B G; Hamulyák, Karly; Hackeng, Tilman M; Daemen, Mat J A P; Degen, Jay L; Weiler, Hartmut; Esmon, Charles T; van Ryn, Joanne; Biessen, Erik A L; Spronk, Henri M H; ten Cate, Hugo

中性粒细胞

细胞生物学

动脉粥样硬化

发表日期：2013

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Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain

在成年小鼠体内基因敲除凝血酶原与生存不相容，并会导致心脏和大脑发生自发性出血事件。

影响因子:23.1

doi:10.1182/blood-2008-07-169003

Mullins, Eric S; Kombrinck, Keith W; Talmage, Kathryn E; Shaw, Maureen A; Witte, David P; Ullman, Joni M; Degen, Sandra J; Sun, William; Flick, Matthew J; Degen, Jay L

发表日期：2009

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Fibrinogen drives dystrophic muscle fibrosis via a TGFbeta/alternative macrophage activation pathway

纤维蛋白原通过TGFβ/替代性巨噬细胞激活途径驱动营养不良性肌肉纤维化。

期刊:Genes & Development

影响因子:7.7

doi:10.1101/gad.465908

Vidal, Berta; Serrano, Antonio L; Tjwa, Marc; Suelves, Mònica; Ardite, Esther; De Mori, Roberta; Baeza-Raja, Bernat; Martínez de Lagrán, María; Lafuste, Peggy; Ruiz-Bonilla, Vanessa; Jardí, Mercè; Gherardi, Romain; Christov, Christo; Dierssen, Mara; Carmeliet, Peter; Degen, Jay L; Dewerchin, Mieke; Muñoz-Cánoves, Pura

细胞生物学

免疫/内分泌

发表日期：2008

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