日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of Coronavirus Main Protease Inhibitors with Enhanced Brain Exposure and Potent Oral Efficacy in SARS-CoV-2 and MERS Infection Models

在SARS-CoV-2和MERS感染模型中发现具有增强脑暴露和强效口服疗效的冠状病毒主要蛋白酶抑制剂

Lizzadro, Luca; Li, Jiapeng; Taha, Taha Y; Degotte, Gilles; Detomasi, Tyler C; Zapatero-Belinchon, Francisco J; Hantz, Eric R; Huang, Sijie; Matsui, Yusuke; Henderson, Will R; McCann, Jack T; Montano, Mauricio; Rosecrans, Julia; Torres Pomares, Daniel F; McGovern, Briana L; Diaz-Tapia, Randy; Benjamin, Jared; Gordon, Mary E; Suazo, Isidora D; Settineri, Nicholas S; Diallo, Amy; Krogan, Nevan J; Shoichet, Brian K; Verba, Kliment A; Albrecht, Randy; García-Sastre, Adolfo; White, Kris M; Ott, Melanie; Craik, Charles S; Renslo, Adam R

Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy

基于结构的、具有高效体内疗效的高生物利用度、共价、广谱冠状病毒MPro抑制剂的发现

Tyler C Detomasi ,Gilles Degotte ,Sijie Huang ,Rahul K Suryawanshi ,Amy Diallo ,Luca Lizzadro ,Francisco J Zapatero-Belinchón ,Taha Y Taha ,Jiapeng Li ,Alicia L Richards ,Eric R Hantz ,Zain Alam ,Mauricio Montano ,Maria McCavitt-Malvido ,Rajesh Gumpena ,James R Partridge ,Galen J Correy ,Yusuke Matsui ,Annemarie F Charvat ,Isabella S Glenn ,Julia Rosecrans ,Jezrael L Revalde ,Dashiell Anderson ,Judd F Hultquist ,Michelle R Arkin ,R Jeffrey Neitz ,Danielle L Swaney ,Nevan J Krogan ,Brian K Shoichet ,Kliment A Verba ,Melanie Ott ,Adam R Renslo ,Charles S Craik

Practical implementation of AI in a non-academic, non-commercial Pathology laboratory: Real world experience and lessons learned

在非学术性、非商业性病理实验室中实际应用人工智能:真实世界的经验和教训

Deman, Frederik; Broeckx, Glenn; Declercq, Sabine; Degotte, Quentin; Raymaekers, Jakob; Salgado, Roberto; Dendooven, Amélie

Targeting Myeloperoxidase Activity and Neutrophil ROS Production to Modulate Redox Process: Effect of Ellagic Acid and Analogues

靶向髓过氧化物酶活性和中性粒细胞 ROS 生成来调节氧化还原过程:鞣花酸及其类似物的作用

Gilles Degotte, Michel Frederich, Pierre Francotte, Thierry Franck, Thomas Colson, Didier Serteyn, Ange Mouithys-Mickalad

Towards Arginase Inhibition: Hybrid SAR Protocol for Property Mapping of Chlorinated N-arylcinnamamides

精氨酸酶抑制:氯化 N-芳基肉桂酰胺性质映射的混合 SAR 协议

Andrzej Bak, Jiri Kos, Gilles Degotte, Aleksandra Swietlicka, Tomas Strharsky, Dominika Pindjakova, Tomas Gonec, Adam Smolinski, Pierre Francotte, Michel Frederich, Violetta Kozik, Josef Jampilek

Unveiling antiplasmodial alkaloids from a cumulative collection of Strychnos extracts by multi-informative molecular networks

通过多信息分子网络揭示马钱子提取物累积集合中的抗疟原虫生物碱

Olivier Bonnet, Mehdi A Beniddir, Pierre Champy, Gilles Degotte, Lúcia Mamede, Pauline Desdemoustier, Allison Ledoux, Alembert Tiabou Tchinda, Luc Angenot, Michel Frédérich