日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease

利用腺相关病毒基因疗法治疗胆固醇24-羟化酶可减少阿尔茨海默病小鼠模型中淀粉样斑块形成前后的淀粉样蛋白病理。

Hudry, Eloise; Van Dam, Debby; Kulik, Wim; De Deyn, Peter P; Stet, Femke S; Ahouansou, Ornella; Benraiss, Abdellatif; Delacourte, André; Bougnères, Pierre; Aubourg, Patrick; Cartier, Nathalie

The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons

孤儿 G 蛋白偶联受体 3 调节神经元中的淀粉样β肽生成

Amantha Thathiah, Kurt Spittaels, Marcel Hoffmann, Mik Staes, Adrian Cohen, Katrién Horré, Mieke Vanbrabant, Frea Coun, Veerle Baekelandt, André Delacourte, David F Fischer, Dirk Pollet, Bart De Strooper, Pascal Merchiers

Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration

钙蛋白酶水解α-和β2-适应性蛋白可降低网格蛋白依赖性内吞作用,并可能促进神经退行性变

Nikita Rudinskiy, Yulia Grishchuk, Anne Vaslin, Julien Puyal, André Delacourte, Harald Hirling, Peter G H Clarke, Ruth Luthi-Carter

Neuroimaging outcomes in clinical trials in Alzheimer's disease

阿尔茨海默病临床试验中的神经影像学结果

Frisoni, G B; Delacourte, A

Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity

β位点APP裂解酶1(BACE1)参与淀粉样前体蛋白介导的记忆增强和活动依赖性突触可塑性

Ma, Huifang; Lesné, Sylvain; Kotilinek, Linda; Steidl-Nichols, Jill V; Sherman, Mathew; Younkin, Linda; Younkin, Steven; Forster, Colleen; Sergeant, Nicolas; Delacourte, André; Vassar, Robert; Citron, Martin; Kofuji, Paulo; Boland, Linda M; Ashe, Karen H

BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease

BRCA1可能在阿尔茨海默病中调节神经元细胞周期再进入

Evans, Teresa A; Raina, Arun K; Delacourte, André; Aprelikova, Olga; Lee, Hyoung-gon; Zhu, Xiongwei; Perry, George; Smith, Mark A

Proteasome inhibition and Tau proteolysis: an unexpected regulation

蛋白酶体抑制与Tau蛋白水解:一种意想不到的调控

Delobel, P; Leroy, O; Hamdane, M; Sambo, A V; Delacourte, A; Buée, L

Raft disorganization leads to reduced plasmin activity in Alzheimer's disease brains

阿尔茨海默病患者大脑中纤溶酶活性降低是由于脂筏结构紊乱所致。

Ledesma, Maria Dolores; Abad-Rodriguez, José; Galvan, Cristian; Biondi, Elisa; Navarro, Pilar; Delacourte, Andre; Dingwall, Colin; Dotti, Carlos G

Brain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced in Alzheimer's disease brains

脑纤溶酶可增强APPα裂解和Aβ降解,但在阿尔茨海默病患者的大脑中含量降低。

Ledesma, M D; Da Silva, J S; Crassaerts, K; Delacourte, A; De Strooper, B; Dotti, C G

Comparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's disease

进行性核上性麻痹、皮质基底节变性、FTDP-17 和 Pick 病中 tau 蛋白的比较生物化学研究

Buée, L; Delacourte, A