日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces

具有更长重复拓扑和增强亚基接触表面的功能化环状串联重复蛋白的设计

Jazmine P Hallinan #, Lindsey A Doyle #, Betty W Shen, Mesfin M Gewe, Brittany Takushi, Madison A Kennedy, Della Friend, James M Roberts, Philip Bradley, Barry L Stoddard

A TfR-Binding Cystine-Dense Peptide Promotes Blood-Brain Barrier Penetration of Bioactive Molecules

TfR 结合胱氨酸致密肽促进生物活性分子穿透血脑屏障

Zachary R Crook, Emily Girard, Gregory P Sevilla, Morgan Merrill, Della Friend, Peter B Rupert, Fiona Pakiam, Elizabeth Nguyen, Chunfeng Yin, Raymond O Ruff, Gene Hopping, Andrew D Strand, Kathryn A K Finton, Margo Coxon, Andrew J Mhyre, Roland K Strong, James M Olson

Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets

针对难以药物靶点的多种胱氨酸致密肽的哺乳动物展示筛选

Zachary R Crook, Gregory P Sevilla, Della Friend, Mi-Youn Brusniak, Ashok D Bandaranayake, Midori Clarke, Mesfin Gewe, Andrew J Mhyre, David Baker, Roland K Strong, Philip Bradley, James M Olson

Inhibition and Reversal of Microbial Attachment by an Antibody with Parasteric Activity against the FimH Adhesin of Uropathogenic E. coli

具有抗泌尿道致病性大肠杆菌 FimH 粘附素的寄生活性抗体对微生物附着的抑制和逆转

Dagmara I Kisiela, Hovhannes Avagyan, Della Friend, Aachal Jalan, Shivani Gupta, Gianluca Interlandi, Yan Liu, Veronika Tchesnokova, Victoria B Rodriguez, John P Sumida, Roland K Strong, Xue-Ru Wu, Wendy E Thomas, Evgeni V Sokurenko

Ontogeny of recognition specificity and functionality for the broadly neutralizing anti-HIV antibody 4E10

广谱中和抗 HIV 抗体 4E10 的识别特异性和功能性

Kathryn A K Finton, Della Friend, James Jaffe, Mesfin Gewe, Margaret A Holmes, H Benjamin Larman, Andrew Stuart, Kevin Larimore, Philip D Greenberg, Stephen J Elledge, Leonidas Stamatatos, Roland K Strong

Autoreactivity and exceptional CDR plasticity (but not unusual polyspecificity) hinder elicitation of the anti-HIV antibody 4E10

自身反应性和异常的 CDR 可塑性(但并非不寻常的多特异性)阻碍了抗 HIV 抗体 4E10 的产生

Kathryn A K Finton, Kevin Larimore, H Benjamin Larman, Della Friend, Colin Correnti, Peter B Rupert, Stephen J Elledge, Philip D Greenberg, Roland K Strong

Binding interactions between soluble HIV envelope glycoproteins and quaternary-structure-specific monoclonal antibodies PG9 and PG16

可溶性HIV包膜糖蛋白与四级结构特异性单克隆抗体PG9和PG16之间的结合相互作用

Thaddeus M Davenport, Della Friend, Katharine Ellingson, Hengyu Xu, Zachary Caldwell, George Sellhorn, Zane Kraft, Roland K Strong, Leonidas Stamatatos