日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting Aurora Kinases as Essential Cell-Cycle Regulators to Deliver Multi-Stage Antimalarials Against Plasmodium Falciparum

以 Aurora 激酶为关键细胞周期调节因子,开发针对恶性疟原虫的多阶段抗疟药物

Langeveld, Henrico; Maepa, Keletso; Maree, Marché; Thibaud, Jessica L; Salomane, Nicolaas; Bridgwater, Rosie; Famodimu, Mufuliat T; Godoy, Luiz C; Pasaje, Charisse Flerida A; Boonyalai, Nonlawat; de Souza, Mariana Laureano; Fong, Justin; Rabie, Tayla; van der Watt, Mariëtte; Theart, Rensu P; Ghidelli-Disse, Sonja; Niles, Jacquin C; Lee, Marcus C S; Winzeler, Elizabeth A; Delves, Michael J; Chibale, Kelly; Wicht, Kathryn J; Coulson, Lauren B; Birkholtz, Lyn-Marié

Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4

优化和表征靶向 PfATP4 的 N-乙酰胺吲哚类抗疟药

Awalt, Jon Kyle; Ooi, Zi Kang; Ashton, Trent D; Mansouri, Mahta; Calic, Petar P S; Zhou, Qingmiao; Vasanthan, Santhya; Lee, Serena; Loi, Katie; Jarman, Kate E; Penington, Jocelyn S; Qiu, Deyun; Zhang, Xinxin; Lehane, Adele M; Mao, Emma Y; Gancheva, Maria R; Wilson, Danny W; Giannangelo, Carlo; MacRaild, Christopher A; Creek, Darren J; Yeo, Tomas; Sheth, Tanaya; Fidock, David A; Churchyard, Alisje; Baum, Jake; Famodimu, Mufuliat T; Delves, Michael J; Kristan, Mojca; Stewart, Lindsay; Sutherland, Colin J; Coyle, Rachael; Jagoe, Hannah; Lee, Marcus C S; Chowdury, Mrittika; de Koning-Ward, Tania F; Baud, Delphine; Brand, Stephen; Jackson, Paul F; Cowman, Alan F; Dans, Madeline G; Sleebs, Brad E

Optimization and Characterization of the Antimalarial Activity of N-Aryl Acetamides that are Susceptible to Mutations in ROM8 and CSC1

对易受ROM8和CSC1突变影响的N-芳基乙酰胺类化合物的抗疟活性进行优化和表征

Nguyen, William; Boulet, Coralie; Dans, Madeline G; Loi, Katie; Jarman, Kate E; Barnes, Claudia B G; Yeo, Tomas; Sheth, Tanaya; Mukherjee, Partha; Chakraborty, Arnish; Famodimu, Mufuliat T; Delves, Michael J; Pollard, Harry; Sutherland, Colin J; Coyle, Rachael; Sevilleno, Nicole; Boonyalai, Nonlawat; Lee, Marcus C S; Rabie, Tayla; Birkholtz, Lyn-Marié; Baud, Delphine; Brand, Stephen; Chowdury, Mrittika; de Koning-Ward, Tania F; Fidock, David A; Gilson, Paul R; Sleebs, Brad E

Correction: Machine learning-based phenotypic imaging to characterise the targetable biology of Plasmodium falciparum male gametocytes for the development of transmission-blocking antimalarials

更正:基于机器学习的表型成像技术用于表征恶性疟原虫雄性配子体的可靶向生物学特性,以开发阻断传播的抗疟药物。

Tsebriy, Oleksiy; Khomiak, Andrii; Miguel-Blanco, Celia; Sparkes, Penny C; Gioli, Maurizio; Santelli, Marco; Whitley, Edgar; Gamo, Francisco-Javier; Delves, Michael J

Characterizing the quick-killing mechanism of action of azithromycin analogs against malaria parasites

阐明阿奇霉素类似物对疟原虫的快速杀灭机制

Mao, Emma Y; Nguyen, William; Jana, Gouranga P; Maity, Bikash C; Pazicky, Samuel; Giannangelo, Carlo; Reader, Janette; Famodimu, Mufuliat T; Birkholtz, Lyn-Marie; Delves, Michael J; Creek, Darren J; Bozdech, Zbynek; Laleu, Benoît; Burrows, Jeremy N; Sleebs, Brad E; Gancheva, Maria R; Wilson, Danny W

Author Correction: Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1

作者更正:芳基氨基乙酰胺通过靶向脂质转移蛋白 PfSTART1 来阻止恶性疟原虫环的形成。

Dans, Madeline G; Boulet, Coralie; Watson, Gabrielle M; Nguyen, William; Dziekan, Jerzy M; Evelyn, Cindy; Reaksudsan, Kitsanapong; Mehra, Somya; Razook, Zahra; Geoghegan, Niall D; Mlodzianoski, Michael J; Goodman, Christopher Dean; Ling, Dawson B; Jonsdottir, Thorey K; Tong, Joshua; Famodimu, Mufuliat Toyin; Kristan, Mojca; Pollard, Harry; Stewart, Lindsay B; Brandner-Garrod, Luke; Sutherland, Colin J; Delves, Michael J; McFadden, Geoffrey I; Barry, Alyssa E; Crabb, Brendan S; de Koning-Ward, Tania F; Rogers, Kelly L; Cowman, Alan F; Tham, Wai-Hong; Sleebs, Brad E; Gilson, Paul R

Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4

二氢喹唑啉酮-3-甲酰胺类化合物作为靶向PfATP4的口服有效抗疟药的性质和活性优化

Ashton, Trent D; Calic, Petar P S; Dans, Madeline G; Ooi, Zi Kang; Zhou, Qingmiao; Palandri, Josephine; Loi, Katie; Jarman, Kate E; Qiu, Deyun; Lehane, Adele M; Maity, Bikash Chandra; De, Nirupam; Giannangelo, Carlo; MacRaild, Christopher A; Creek, Darren J; Mao, Emma Y; Gancheva, Maria R; Wilson, Danny W; Chowdury, Mrittika; de Koning-Ward, Tania F; Famodimu, Mufuliat T; Delves, Michael J; Pollard, Harry; Sutherland, Colin J; Baud, Delphine; Brand, Stephen; Jackson, Paul F; Cowman, Alan F; Sleebs, Brad E

Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b

探索和表征靶向线粒体蛋白细胞色素b的环丙基羧酰胺类化合物的抗疟活性

Awalt, Jon Kyle; Su, Wenyin; Nguyen, William; Loi, Katie; Jarman, Kate E; Penington, Jocelyn S; Ramesh, Saishyam; Fairhurst, Kate J; Yeo, Tomas; Park, Heekuk; Uhlemann, Anne-Catrin; Chandra Maity, Bikash; De, Nirupam; Mukherjee, Partha; Chakraborty, Arnish; Churchyard, Alisje; Famodimu, Mufuliat T; Delves, Michael J; Baum, Jake; Mittal, Nimisha; Winzeler, Elizabeth A; Papenfuss, Anthony T; Chowdury, Mrittika; de Koning-Ward, Tania F; Maier, Alexander G; van Dooren, Giel G; Baud, Delphine; Brand, Stephen; Fidock, David A; Jackson, Paul F; Cowman, Alan F; Dans, Madeline G; Sleebs, Brad E

Mitochondrial ATP synthesis is essential for efficient gametogenesis in Plasmodium falciparum

线粒体ATP合成对于恶性疟原虫的有效配子发生至关重要

Sparkes, Penny C; Famodimu, Mufuliat Toyin; Alves, Eduardo; Springer, Eric; Przyborski, Jude; Delves, Michael J

A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo.

一种强效且选择性的恶性疟原虫酪氨酸 tRNA 合成酶反应劫持抑制剂在体内表现出单剂量口服疗效

Xie Stanley C, Tai Chia-Wei, Morton Craig J, Ma Liting, Huang Shih-Chung, Wittlin Sergio, Du Yawei, Hu Yongbo, Dogovski Con, Salimimarand Mina, Griffin Robert, England Dylan, de la Cruz Elisa, Deni Ioanna, Yeo Tomas, Burkhard Anna Y, Striepen Josefine, Schindler Kyra A, Crespo Benigno, Gamo Francisco J, Khandokar Yogesh, Hutton Craig A, Rabie Tayla, Birkholtz Lyn-Marié, Famodimu Mufuliat T, Delves Michael J, Bolsher Judith, Koolen Karin M J, van der Laak Rianne, Aguiar Anna C C, Pereira Dhelio B, Guido Rafael V C, Creek Darren J, Fidock David A, Dick Lawrence R, Brand Stephen L, Gould Alexandra E, Langston Steven, Griffin Michael D W, Tilley Leann