日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Human microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carrying SCN2A mutation.

脑集合体中的人类小胶质细胞表现出区域特异性多样性,并对携带 SCN2A 突变的过度兴奋神经元做出反应。

Wu Jiaxiang, Chen Xiaoling, Zhang Jingliang, Wettschurack Kyle, Robinson Morgan, Li Weihao, Zhao Yuanrui, Yoo Ye-Eun, Deming Brody A, Shu Yue, Abeyaratna Akila D, Que Zhefu, Du Dongshu, Tegtmeyer Matthew, Yuan Chongli, Skarnes William C, Zhang Zhong-Yin, Rochet Jean-Christophe, Wu Long-Jun, Yang Yang

Single-nucleus transcriptomics reveal disrupted pathways in the prefrontal cortex of Scn2a -deficient mice

单核转录组学揭示了Scn2a缺陷小鼠前额叶皮层中受损的通路

Yoo, Ye-Eun; Mandal, Purba; Tang, Zhengkuan; Zhang, Zaiyang; Zhang, Jingliang; Chen, Xiaoling; Robinson, Morgan; Eaton, Muriel; Deming, Brody; Halurkar, Manasi; Kothandaraman, Harish; Dabin, Luke C; Jiang, Boyu; Gao, Hongyu; Yuan, Chongli; Lanman, Nadia; Liu, Yunlong; Kim, Jungsu; Baloni, Priyanka; Yang, Yang

Human microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carrying SCN2A mutation: Microglial diversity and response in assembloids.

脑集合体中的人类小胶质细胞表现出区域特异性多样性,并对携带 SCN2A 突变的过度兴奋神经元做出反应:集合体中的小胶质细胞多样性和反应

Wu Jiaxiang, Chen Xiaoling, Zhang Jingliang, Wettschurack Kyle, Robinson Morgan, Li Weihao, Zhao Yuanrui, Yoo Ye-Eun, Deming Brody A, Abeyaratna Akila D, Que Zhefu, Du Dongshu, Tegtmeyer Matthew, Yuan Chongli, Skarnes William C, Rochet Jean-Christophe, Wu Long-Jun, Yang Yang

Gene therapies alleviate absence epilepsy associated with Scn2a deficiency in DBA/2J mice.

基因疗法可缓解 DBA/2J 小鼠中与 Scn2a 缺陷相关的失神性癫痫

Zhang Zaiyang, Zhang Jingliang, Chen Xiaoling, Deming Brody A, Kant Shivam, Mandal Purba, Kothandaraman Harish, SanMiguel Phillip J, Halurkar Manasi S, Abeyaratna Akila D, Robinson Morgan J, Zhao Yuanrui, Vitko Yuliia, Gaykema Ronald P, Yuan Chongli, Lanman Nadia A, Tegtmeyer Matthew T, Wang Dan, Gao Guangping, Shi Riyi, Perez-Reyes Edward, Yang Yang

Restoration of excitation/inhibition balance enhances neuronal signal-to-noise ratio and rescues social deficits in autism-associated Scn2a-deficiency.

恢复兴奋/抑制平衡可提高神经元信噪比,并挽救自闭症相关 Scn2a 缺陷引起的社交缺陷

Zhang Jingliang, Eaton Muriel, Chen Xiaoling, Zhao Yuanrui, Kant Shivam, Deming Brody A, Harish Kothandaraman, Nguyen Huynhvi P, Shu Yue, Lai Shirong, Wu Jiaxiang, Que Zhefu, Wettschurack Kyle W, Zhang Zaiyang, Xiao Tiange, Halurkar Manasi S, Olivero-Acosta Maria I, Yoo Ye-Eun, Lanman Nadia A, Koss Wendy A, Skarnes William C, Yang Yang

Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation.

人类 iPSC 衍生的小胶质细胞能够感知并抑制携带癫痫相关 SCN2A-L1342P 突变的皮层神经元的过度兴奋

Que Zhefu, Olivero-Acosta Maria I, Robinson Morgan, Chen Ian, Zhang Jingliang, Wettschurack Kyle, Wu Jiaxiang, Xiao Tiange, Otterbacher C Max, Shankar Vinayak, Harlow Hope, Hong Seoyong, Zirkle Benjamin, Wang Muhan, Cui Ningren, Mandal Purba, Chen Xiaoling, Deming Brody, Halurkar Manasi, Zhao Yuanrui, Rochet Jean-Christophe, Xu Ranjie, Brewster Amy L, Wu Long-Jun, Yuan Chongli, Skarnes William C, Yang Yang