Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma
在胶质母细胞瘤的临床前模型中,强效PI3K和MAPK抑制剂的联合疗法可克服对单一药物的适应性激酶组耐药性。
期刊:Neuro-Oncology
影响因子:13.4
doi:10.1093/neuonc/nox044
McNeill, Robert S; Canoutas, Demitra A; Stuhlmiller, Timothy J; Dhruv, Harshil D; Irvin, David M; Bash, Ryan E; Angus, Steven P; Herring, Laura E; Simon, Jeremy M; Skinner, Kasey R; Limas, Juanita C; Chen, Xin; Schmid, Ralf S; Siegel, Marni B; Van Swearingen, Amanda E D; Hadler, Michael J; Sulman, Erik P; Sarkaria, Jann N; Anders, Carey K; Graves, Lee M; Berens, Michael E; Johnson, Gary L; Miller, C Ryan