Demmerle相关文献与解析，生知库 | 链接生命科学的每一步

Hao, Siyuan; Lee, Ye Jin; Goldfajn, Nadav Benhamou; Flores, Eduardo; Liang, Jindayi; Fuehrer, Hannah; Demmerle, Justin; Lippincott-Schwartz, Jennifer; Liu, Zhe; Sukenik, Shahar; Cai, Danfeng

YAP

发表日期：2026

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The homeobox transcription factor MNX1 regulates the expression of many non-MN-specific neuronal genes in motor neurons

同源异型盒转录因子MNX1调控运动神经元中许多非运动神经元特异性神经元基因的表达。

期刊:Nucleic Acids Research

影响因子:16.6

doi:10.1093/nar/gkaf1015.

Ming-An Sun,Hairui Fan,Sherry Ralls,Warren Wu,Justin Demmerle,Jiayao Jiang,Jinpu Jin,Carson J Miller,Gernot Wolf,Todd S Macfarlan

Paraspeckle protein NONO regulates active chromatin by allosterically stimulating NSD1

副斑蛋白NONO通过变构刺激NSD1来调节活性染色质。

期刊:Cell Reports

影响因子:7.5

doi:10.1016/j.celrep.2025.116247.

Chen-I Hsu ,Shenglin Mei ,Justin Demmerle ,Anil Prakash ,Sarah Ruttenberg ,Mahnue Sahn ,Jia-Ray Yu

Melanocyte differentiation and mechanosensation are differentially modulated by distinct extracellular matrix proteins

黑素细胞分化和机械感觉受不同的细胞外基质蛋白差异性调节。

期刊:EMBO Reports

影响因子:6.5

doi:10.1038/s44319-025-00583-6

Carole Luthold ，Marie Didion ，Vanessa Samira Rácz ，Emilio Benedum ，Ann-Kathrin Burkhart ，Nina Demmerle ，Evelyn Wirth ，Gubesh Gunaratnam ，Sudharshini Thangamurugan ，Volkhard Helms ，Markus Bischoff ，Annika Ridzal ，Sandra Iden

细胞生物学

发表日期：2025

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Primary CD34(+) cells of patients with vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome are highly sensitive to targeted treatment with TAK-243

患有空泡、E1酶、X连锁、自身炎症性体细胞（VEXAS）综合征的患者的原代CD34(+)细胞对TAK-243靶向治疗高度敏感。

期刊:British Journal of Haematology

影响因子:3.8

doi:10.1111/bjh.70203

Nowak, Daniel; Demmerle, Marie; Klär, Alessa; Streuer, Alexander; Riabov, Vladimir; Altrock, Eva; Rapp, Felicitas; Belzer, Ann-Christin; Klink, Teresa; Hahn, Meret; Hofmann, Franziska; Nowak, Verena; Weimer, Nadine; Obländer, Julia; Palme, Iris; Göl, Melda; Darwich, Ali; Steiner, Laurenz; Abba, Mohammed; Metzgeroth, Georgia; Hofmann, Wolf-Karsten; Schmitt, Nanni

TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin

TEAD1 凝聚体是着丝粒周围异染色质上转录不活跃的储存位点。

期刊:

影响因子:

doi:10.1101/2025.05.02.651992

Liang, Jindayi; Wang, Yiran; Demmerle, Justin; He, Britney Jiayu; Ricketts, Christopher J; Marston Linehan, W; Zang, Chongzhi; Cai, Danfeng

发表日期：2025

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Stress-induced loss of CTCF reveals an alternative, promoter-based mode of cohesin looping.

应激诱导的 CTCF 丢失揭示了一种替代的、基于启动子的黏连蛋白环化模式。

期刊:

影响因子:

doi:10.64898/2025.12.19.695003

Flores J P, Perreault Andrea A, Drum Zack, Xu Chenxi, Alonso Doris Cruz, Petros Gelila, Wu Yijia, Quiroga-Barber Ivana Y, Kim HyunAh, Sahasrabudhe Isha, Demmerle Justin, Wang Gang Greg, Cai Danfeng, Phanstiel Douglas H

CTCF

发表日期：2025

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ASXL1 mutations are associated with a response to alvocidib and 5-azacytidine combination in myelodysplastic neoplasms

ASXL1 突变与骨髓增生异常综合征患者对阿洛西地布和 5-氮杂胞苷联合治疗的反应相关。

期刊:Haematologica

影响因子:7.9

doi:10.3324/haematol.2023.282921

Riabov, Vladimir; Xu, Qingyu; Schmitt, Nanni; Streuer, Alexander; Ge, Guo; Bolanos, Lyndsey; Wunderlich, Mark; Jann, Johann-Christoph; Wein, Alina; Altrock, Eva; Demmerle, Marie; Mukherjee, Sanjay; Ali, Abdullah Mahmood; Rapp, Felicitas; Nowak, Verena; Weimer, Nadine; Obländer, Julia; Palme, Iris; Göl, Melda; Jawhar, Ahmed; Darwich, Ali; Wuchter, Patrick; Weiss, Christel; Raza, Azra; Foulks, Jason M; Starczynowski, Daniel T; Yang, Feng-Chun; Metzgeroth, Georgia; Steiner, Laurenz; Jawhar, Mohamad; Hofmann, Wolf-Karsten; Nowak, Daniel

ASXL1

发表日期：2024

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YAP condensates are highly organized hubs

YAP 凝结物是高度有序的枢纽。

期刊:iScience

影响因子:4.6

doi:10.1016/j.isci.2024.109927

Siyuan Hao ,Ye Jin Lee ,Nadav Benhamou Goldfajn ,Eduardo Flores ,Jindayi Liang ,Hannah Fuehrer ,Justin Demmerle ,Jennifer Lippincott-Schwartz ,Zhe Liu ,Shahar Sukenik ,Danfeng Cai

YAP

发表日期：2024

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Treatment with the apoptosis inhibitor Asunercept reduces clone sizes in patients with lower risk Myelodysplastic Neoplasms

使用凋亡抑制剂阿舒那西普治疗可减少低危骨髓增生异常综合征患者的克隆大小。

期刊:Annals of Hematology

影响因子:2.4

doi:10.1007/s00277-024-05664-5

Streuer, Alexander; Jann, Johann-Christoph; Boch, Tobias; Mossner, Maximilian; Riabov, Vladimir; Schmitt, Nanni; Altrock, Eva; Xu, Qingyu; Demmerle, Marie; Nowak, Verena; Oblaender, Julia; Palme, Iris; Weimer, Nadine; Rapp, Felicitas; Metzgeroth, Georgia; Hecht, Anna; Höger, Thomas; Merz, Christian; Hofmann, Wolf-Karsten; Nolte, Florian; Nowak, Daniel

Erratum: YAP condensates are highly organized hubs

更正：YAP 凝聚态是高度有序的枢纽。

The homeobox transcription factor MNX1 regulates the expression of many non-MN-specific neuronal genes in motor neurons

同源异型盒转录因子MNX1调控运动神经元中许多非运动神经元特异性神经元基因的表达。

Paraspeckle protein NONO regulates active chromatin by allosterically stimulating NSD1

副斑蛋白NONO通过变构刺激NSD1来调节活性染色质。

Melanocyte differentiation and mechanosensation are differentially modulated by distinct extracellular matrix proteins

黑素细胞分化和机械感觉受不同的细胞外基质蛋白差异性调节。

Primary CD34(+) cells of patients with vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome are highly sensitive to targeted treatment with TAK-243

患有空泡、E1酶、X连锁、自身炎症性体细胞（VEXAS）综合征的患者的原代CD34(+)细胞对TAK-243靶向治疗高度敏感。

TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin

TEAD1 凝聚体是着丝粒周围异染色质上转录不活跃的储存位点。

Stress-induced loss of CTCF reveals an alternative, promoter-based mode of cohesin looping.

应激诱导的 CTCF 丢失揭示了一种替代的、基于启动子的黏连蛋白环化模式。

ASXL1 mutations are associated with a response to alvocidib and 5-azacytidine combination in myelodysplastic neoplasms

ASXL1 突变与骨髓增生异常综合征患者对阿洛西地布和 5-氮杂胞苷联合治疗的反应相关。

YAP condensates are highly organized hubs

YAP 凝结物是高度有序的枢纽。

Treatment with the apoptosis inhibitor Asunercept reduces clone sizes in patients with lower risk Myelodysplastic Neoplasms

使用凋亡抑制剂阿舒那西普治疗可减少低危骨髓增生异常综合征患者的克隆大小。