文献库，生知库 | 链接生命科学的每一步

日期影响因子

Integrating polygenic signals and single-cell multiomics identifies cell-type-specific regulomes critical for immune- and aging-related diseases

整合多基因信号和单细胞多组学数据，可识别对免疫和衰老相关疾病至关重要的细胞类型特异性调控组。

期刊:Nature Aging

影响因子:19.4

doi:10.1038/s43587-025-01027-5

Ma, Yunlong; Yao, Yinghao; Zhou, Yijun; Dai, Wei; Li, Jingjing; Gui, Yuanyuan; Sun, Haojun; Zhu, Zhengbiao; Jiang, Dingping; Chen, Cheng; Deng, Chunyu; Huang, Yizhou; Han, Haijun; Zhou, Jianhong; Su, Jianzhong

免疫/内分泌

细胞生物学

发表日期：2026

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p300 upregulates I kur in atrial cardiomyocytes through activating NLRP3 inflammasome in hypertension

p300 通过激活 NLRP3 炎症小体上调心房心肌细胞中的 I kur，从而导致高血压

期刊:Chinese Medical Journal

影响因子:7.3

doi:10.1097/CM9.0000000000003501

Zeng, Long; Liu, Panyue; Rao, Fang; Du, Zhimin; Xiao, Haiyin; Yu, Shenghuan; Deng, Chunyu; Zhang, Mengzhen; Liu, Fangzhou; Zhu, Rui; Deng, Hai; Wu, Shulin; Xue, Yumei; Fang, Xianhong; Wei, Wei

细胞生物学

免疫/内分泌

发表日期：2026

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Systematic dissection of pleiotropic loci and critical regulons in excitatory neurons and microglia relevant to neuropsychiatric and ocular diseases

对与神经精神疾病和眼科疾病相关的兴奋性神经元和小胶质细胞中的多效性基因位点和关键调控子进行系统性解析

期刊:Translational Psychiatry

影响因子:6.2

doi:10.1038/s41398-025-03243-4

Ma, Yunlong; Jiang, Dingping; Li, Jingjing; Zheng, Gongwei; Deng, Yao; Gou, Xuanxuan; Gao, Shuaishuai; Chen, Cheng; Zhou, Yijun; Zhang, Yaru; Deng, Chunyu; Yao, Yinghao; Han, Haijun; Su, Jianzhong

细胞生物学

发表日期：2025

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Targeting LAG3 to alter the tumor immune reactivity of CD8+T cells is a potential therapy for skin cutaneous melanoma.

靶向 LAG3 以改变 CD8+T 细胞的肿瘤免疫反应性是治疗皮肤黑色素瘤的一种潜在疗法。

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-025-22377-5

Gong Jin, Zhao Yan, Gong Shaozhi, Deng Chunyu, Zhou Yajie

细胞生物学

发表日期：2025

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Distinct discrepancy in breast cancer organoids recapitulation among molecular subtypes revealed by single-cell transcriptomes analysis

单细胞转录组分析揭示乳腺癌类器官在不同分子亚型间的重现性存在显著差异

期刊:Clinical and Translational Medicine

影响因子:6.8

doi:10.1002/ctm2.70023

Jia, Ziqi; Xu, Hengyi; Zhang, Yaru; Cao, Heng; Deng, Chunyu; Xu, Longchen; Sun, Yuning; Li, Jiayi; Huang, Yansong; Pu, Pengming; Shang, Tongxuan; Wang, Xiang; Su, Jianzhong; Liu, Jiaqi

细胞生物学

发表日期：2024

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Integration of human organoids single-cell transcriptomic profiles and human genetics repurposes critical cell type-specific drug targets for severe COVID-19

整合人类类器官单细胞转录组谱和人类遗传学信息，重新利用关键细胞类型特异性药物靶点治疗重症新冠肺炎

期刊:Cell Proliferation

影响因子:5.6

doi:10.1111/cpr.13558

Ma, Yunlong; Zhou, Yijun; Jiang, Dingping; Dai, Wei; Li, Jingjing; Deng, Chunyu; Chen, Cheng; Zheng, Gongwei; Zhang, Yaru; Qiu, Fei; Sun, Haojun; Xing, Shilai; Han, Haijun; Qu, Jia; Wu, Nan; Yao, Yinghao; Su, Jianzhong

细胞生物学

发表日期：2024

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Mendelian randomization analysis reveals a causal effect of Streptococcus salivarius on diabetic retinopathy through regulating host fasting glucose

孟德尔随机化分析揭示了唾液链球菌通过调节宿主空腹血糖对糖尿病视网膜病变的因果效应

期刊:Journal of Cellular and Molecular Medicine

影响因子:4.2

doi:10.1111/jcmm.18200

Li, Jingjing; Zheng, Gongwei; Jiang, Dingping; Deng, Chunyu; Zhang, Yaru; Ma, Yunlong; Su, Jianzhong

糖尿病视网膜病变

视网膜病变

发表日期：2024

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Curcumin improves atrial fibrillation susceptibility by regulating tsRNA expression in aging mouse atrium

姜黄素通过调节衰老小鼠心房中tsRNA的表达来改善心房颤动的易感性

影响因子:2.4

doi:10.7717/peerj.17495

Luo, Xueshan; Liu, Panyue; Ye, Xingdong; He, Jintao; Lai, Yingyu; Lv, Yidong; Wu, Xiongbin; Liu, Yang; Zhang, Qianhuan; Yang, Hui; Wei, Wei; Deng, Chunyu; Kuang, Sujuan; Wu, Shulin; Xue, Yumei; Rao, Fang

发表日期：2024

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Polygenic regression uncovers trait-relevant cellular contexts through pathway activation transformation of single-cell RNA sequencing data

多基因回归通过单细胞RNA测序数据的通路激活转化揭示与性状相关的细胞环境

期刊:Cell Genomics

doi:10.1016/j.xgen.2023.100383

Ma, Yunlong; Deng, Chunyu; Zhou, Yijun; Zhang, Yaru; Qiu, Fei; Jiang, Dingping; Zheng, Gongwei; Li, Jingjing; Shuai, Jianwei; Zhang, Yan; Yang, Jian; Su, Jianzhong

细胞生物学

发表日期：2023

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Unraveling temporal and spatial biomarkers of epithelial-mesenchymal transition in colorectal cancer: insights into the crucial role of immunosuppressive cells

揭示结直肠癌上皮-间质转化的时空生物标志物：深入了解免疫抑制细胞的关键作用

期刊:Journal of Translational Medicine

影响因子:7.5

doi:10.1186/s12967-023-04600-x

Wang, Muhong; Deng, Chunyu; Yang, Cheng; Yan, Mingze; Lu, Haibo; Zhang, Yan; Liu, Honghao; Tong, Zhekuan; Ma, Jiaao; Wang, Jiaming; Zhang, Yan; Wang, Jiahao; Xuan, Yuhong; Cheng, Haiyue; Zhao, Kai; Zhang, Jiaqi; Chai, Cuicui; Li, Mingzhe; Yu, Zhiwei

细胞生物学

免疫/内分泌

发表日期：2023

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