Deng Hongkui相关文献与解析，生知库 | 链接生命科学的每一步

Wang, Yanglu; Peng, Fangqi; Cheng, Ruoqi; Zeng, Jingran; Zeng, Weizhen; Mao, Jingping; Fu, Xiaodi; Chen, Guanxian; Liu, Tianxing; Yang, Zhihan; Li, Cheng; Liu, Bei; Guan, Jingyang; Cheng, Lin; Deng, Hongkui

发育与干细胞

T细胞

干细胞

Trophectoderm-like cells from EPS cells enable generating EPS cell-derived post-implantation embryoids that complete gastrulation

来自EPS细胞的滋养外胚层样细胞能够生成EPS细胞衍生的植入后胚状体，这些胚状体能够完成原肠胚形成。

期刊:Protein & Cell

影响因子:12.8

doi:10.1093/procel/pwaf059

Wang, Xuyang; Cheng, Ruoqi; Wu, Chenyang; Liu, Haiyin; Li, Zining; Huo, Yunfei; Li, Bo; Zhao, Dongyu; Li, Cheng; Deng, Hongkui; Xu, Jun

细胞生物学

发表日期：2026

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A continuous totipotent-like cell-based embryo model recapitulates mouse embryogenesis from zygotic genome activation to gastrulation.

基于连续全能样细胞的胚胎模型重现了从合子基因组激活到原肠胚形成的鼠胚胎发生过程。

期刊:Nature Cell Biology

影响因子:19.1

doi:10.1038/s41556-025-01793-9

Ren Yixuan, Wang Xuyang, Liu Haiyin, Xu Yaxing, Cheng Ruoqi, Ren Shengnan, Li Zining, Huo Yunfei, Li Bo, Guan Jingyang, Li Cheng, Deng Hongkui, Xu Jun

Robust generation of clinically applicable human pluripotent stem cells from peripheral blood by chemical reprogramming

利用化学重编程技术从外周血中高效生成具有临床应用价值的人类多能干细胞

期刊:Cell Discovery

影响因子:12.5

doi:10.1038/s41421-025-00852-7

Fu, Xiaodi; Peng, Fangqi; Cai, Ruyi; Mao, Jingping; Liu, Tianxing; Dong, Yingshuai; Cheng, Ruoqi; Yang, Zhihan; Chen, Guanxian; Li, Cheng; Mu, Rong; Cheng, Lin; Wang, Yanglu; Guan, Jingyang; Deng, Hongkui

Potentiating CAR-T cell function in the immunosuppressive tumor microenvironment by inverting the TGF-β signal

通过逆转TGF-β信号增强CAR-T细胞在免疫抑制性肿瘤微环境中的功能

期刊:Molecular Therapy

影响因子:12

doi:10.1016/j.ymthe.2024.12.014

Zheng, Shen; Che, Xuan; Zhang, Kai; Bai, Yun; Deng, Hongkui

Î²-galactosidase-targeted senolytic prodrug ameliorates preclinical models of post-traumatic osteoarthritis.

β-半乳糖苷酶靶向衰老细胞清除前药可改善创伤后骨关节炎的临床前模型。

期刊:EBioMedicine

影响因子:10.8

doi:10.1016/j.ebiom.2025.106015

Li Qi, Wu Tong, Fan Yifei, Cheng Jin, Wang Junyan, Xu Boyang, Sun Mengze, Gong Xi, Deng Hongkui, Ao Yingfang, Hu Xiaoqing

Single-cell transcriptomics reveals liver developmental trajectory during lineage reprogramming of human induced hepatocyte-like cells.

单细胞转录组学揭示了人类诱导肝细胞样细胞谱系重编程过程中肝脏发育轨迹

期刊:Cellular and Molecular Life Sciences

影响因子:6.2

doi:10.1007/s00018-025-05677-x

Jiang Nan, Li Guangya, Luo Sen, Kong Xi, Yin Shigang, Peng Jianhua, Jiang Yong, Tao Wei, Li Cheng, Xie Huangfan, Deng Hongkui, Xie Bingqing

Pluripotent stem cell-based immunotherapy: advances in translational research, cell differentiation, and gene modifications

基于多能干细胞的免疫疗法：转化研究、细胞分化和基因修饰的进展

期刊:Life Medicine

影响因子:6

doi:10.1093/lifemedi/lnaf002

Lei, Qi; Deng, Hongkui; Sun, Shicheng

A two-step strategy to expand primary human hepatocytes in vitro with efficient metabolic and regenerative capacities

一种在体外扩增具有高效代谢和再生能力的原代人肝细胞的两步策略

期刊:Stem Cell Research & Therapy

影响因子:7.3

doi:10.1186/s13287-024-03911-0

Xie, Huangfan; Li, Guangya; Fu, Yunxi; Jiang, Nan; Yi, Simeng; Kong, Xi; Shi, Jihang; Yin, Shigang; Peng, Jianhua; Jiang, Yong; Lu, Shichun; Deng, Hongkui; Xie, Bingqing

A single cell-based computational platform to identify chemical compounds targeting desired sets of transcription factors for cellular conversion

一个基于单细胞的计算平台，用于识别靶向细胞转化所需转录因子集合的化合物

期刊:Stem Cell Reports

影响因子:5.1

doi:10.1016/j.stemcr.2022.10.013

Zheng, Menglin; Xie, Bingqing; Okawa, Satoshi; Liew, Soon Yi; Deng, Hongkui; del Sol, Antonio

Efficient chemical reprogramming of human T cells to pluripotent stem cells

高效化学重编程将人类T细胞转化为多能干细胞

Trophectoderm-like cells from EPS cells enable generating EPS cell-derived post-implantation embryoids that complete gastrulation

来自EPS细胞的滋养外胚层样细胞能够生成EPS细胞衍生的植入后胚状体，这些胚状体能够完成原肠胚形成。

A continuous totipotent-like cell-based embryo model recapitulates mouse embryogenesis from zygotic genome activation to gastrulation.

基于连续全能样细胞的胚胎模型重现了从合子基因组激活到原肠胚形成的鼠胚胎发生过程。

Robust generation of clinically applicable human pluripotent stem cells from peripheral blood by chemical reprogramming

利用化学重编程技术从外周血中高效生成具有临床应用价值的人类多能干细胞

Potentiating CAR-T cell function in the immunosuppressive tumor microenvironment by inverting the TGF-β signal

通过逆转TGF-β信号增强CAR-T细胞在免疫抑制性肿瘤微环境中的功能

Î²-galactosidase-targeted senolytic prodrug ameliorates preclinical models of post-traumatic osteoarthritis.

β-半乳糖苷酶靶向衰老细胞清除前药可改善创伤后骨关节炎的临床前模型。

Single-cell transcriptomics reveals liver developmental trajectory during lineage reprogramming of human induced hepatocyte-like cells.

单细胞转录组学揭示了人类诱导肝细胞样细胞谱系重编程过程中肝脏发育轨迹

Pluripotent stem cell-based immunotherapy: advances in translational research, cell differentiation, and gene modifications

基于多能干细胞的免疫疗法：转化研究、细胞分化和基因修饰的进展

A two-step strategy to expand primary human hepatocytes in vitro with efficient metabolic and regenerative capacities

一种在体外扩增具有高效代谢和再生能力的原代人肝细胞的两步策略

A single cell-based computational platform to identify chemical compounds targeting desired sets of transcription factors for cellular conversion

一个基于单细胞的计算平台，用于识别靶向细胞转化所需转录因子集合的化合物