日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Lentiviral Gene Therapy with CD34+ Hematopoietic Cells for Hemophilia A

利用CD34+造血细胞进行慢病毒基因治疗A型血友病

Srivastava, Alok; Abraham, Aby; Aboobacker, Fouzia; Singh, Gurbind; Geevar, Tulasi; Kulkarni, Uday; Selvarajan, Sushil; Korula, Anu; Dave, Rutvi Gautam; Shankar, Mohana; Singh, Abraham S; Jeba, Anbu; Kumaar, Navien; Benjamin, Christopher; Lakshmi, Kavitha M; Srivastava, Vivi Miriam; Shaji, Ramachandran V; Nair, Sukesh C; Brown, Harrison C; Denning, Gabriela; Lollar, Pete; Doering, Christopher B; Spencer, Trent

Humanization and functional characterization of enhanced coagulation factor IX variants identified through ancestral sequence reconstruction

通过祖先序列重建鉴定的增强型凝血因子IX变体的人源化和功能表征

Coyle, Christopher W; Knight, Kristopher A; Brown, Harrison C; George, Stephan N; Denning, Gabriela; Branella, Gianna M; Childers, Kenneth C; Spiegel, P Clint; Spencer, H Trent; Doering, Christopher B

Pharmacokinetic analysis identifies a factor VIII immunogenicity threshold after AAV gene therapy in hemophilia A mice

药代动力学分析确定了AAV基因治疗后A型血友病小鼠的VIII因子免疫原性阈值。

Lundgren, Taran S; Denning, Gabriela; Stowell, Sean R; Spencer, H Trent; Doering, Christopher B

F5-Atlanta: A novel mutation in F5 associated with enhanced East Texas splicing and FV-short production

F5-Atlanta:一种与增强的东德克萨斯剪接和FV短链产生相关的F5新突变

Zimowski, Karen L; Petrillo, Teodolinda; Ho, Michelle D; Wechsler, Julie; Shields, Jordan E; Denning, Gabriela; Jhita, Navdeep; Rivera, Angel A; Escobar, Miguel A; Kempton, Christine L; Camire, Rodney M; Doering, Christopher B

The 3.2 Ã structure of a bioengineered variant of blood coagulation factor VIII indicates two conformations of the C2 domain.

生物工程改造的血液凝固因子 VIII 变体的 3.2 Ã 结构表明 C2 结构域有两种构象

Smith Ian W, d'Aquino Anne E, Coyle Christopher W, Fedanov Andrew, Parker Ernest T, Denning Gabriela, Spencer Harold Trent, Lollar Pete, Doering Christopher B, Spiegel Paul Clint Jr

Preclinical Development of a Hematopoietic Stem and Progenitor Cell Bioengineered Factor VIII Lentiviral Vector Gene Therapy for Hemophilia A

用于治疗血友病A的造血干细胞和祖细胞生物工程化VIII因子慢病毒载体基因疗法的临床前开发

Doering, Christopher B; Denning, Gabriela; Shields, Jordan E; Fine, Eli J; Parker, Ernest T; Srivastava, Alok; Lollar, Pete; Spencer, H Trent

Lentiviral vector platform for production of bioengineered recombinant coagulation factor VIII

用于生产生物工程重组凝血因子VIII的慢病毒载体平台

Spencer, H Trent; Denning, Gabriela; Gautney, Richard E; Dropulic, Boro; Roy, Andre J; Baranyi, Lajos; Gangadharan, Bagirath; Parker, Ernest T; Lollar, Pete; Doering, Christopher B

Directed engineering of a high-expression chimeric transgene as a strategy for gene therapy of hemophilia A

定向构建高表达嵌合转基因作为血友病A基因治疗策略

Doering, Christopher B; Denning, Gabriela; Dooriss, Kerry; Gangadharan, Bagirath; Johnston, Jennifer M; Kerstann, Keith W; McCarty, David A; Spencer, H Trent

Comparison of factor VIII transgenes bioengineered for improved expression in gene therapy of hemophilia A

比较经生物工程改造以提高表达水平的VIII因子转基因在A型血友病基因治疗中的应用

Dooriss, Kerry L; Denning, Gabriela; Gangadharan, Bagirath; Javazon, Elisabeth H; McCarty, David A; Spencer, H Trent; Doering, Christopher B