日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Domain mapping of disease mutations reveals pathogenic SORL1 variants in Alzheimer's disease

疾病突变的结构域定位揭示了阿尔茨海默病中的致病性SORL1变异

Andersen, Olav M; de Waal, Matthijs W J; Monti, Giulia; Tesi, Niccolo; Jensen, Anne Mette G; de Geus, Christa; van Spaendonk, Rosalina; Vogel, Maartje; Ahmad, Shahzad; Amin, Najaf; Amouyel, Philippe; Beecham, Gary W; Bellenguez, Céline; Berr, Claudine; Bis, Joshua C; Boland, Anne; Bossù, Paola; Bouwman, Femke; Bras, Jose; Charbonnier, Camille; Clarimon, Jordi; Cruchaga, Carlos; Daniele, Antonio; Dartigues, Jean-François; Debette, Stéphanie; Deleuze, Jean-François; Denning, Nicola; DeStefano, Anita L; Dols-Icardo, Oriol; van Duijn, Cornelia M; Farrer, Lindsay A; Fernández, Maria Victoria; van der Flier, Wiesje M; Fox, Nick C; Galimberti, Daniela; Genin, Emmanuelle; Gille, Johan J P; Grenier-Boley, Benjamin; Grozeva, Detelina; Guen, Yann Le; Guerreiro, Rita; Haines, Jonathan L; Holmes, Clive; Hummerich, Holger; Arfan Ikram, M; Kamran Ikram, M; Kawalia, Amit; Kraaij, Robert; Lambert, Jean-Charles; Lathrop, Marc; Lemstra, Afina W; Lleó, Alberto; Myers, Richard M; Mannens, Marcel M A M; Marshall, Rachel; Martin, Eden R; Masullo, Carlo; Mayeux, Richard; Mead, Simon; Mecocci, Patrizia; Meggy, Alun; Mol, Merel O; Nacmias, Benedetta; Naj, Adam C; Napolioni, Valerio; Nicholas Cochran, J; Nicolas, Gaël; Pasquier, Florence; Pastor, Pau; Pericak-Vance, Margaret A; Pijnenburg, Yolande A L; Piras, Fabrizio; Quenez, Olivier; Ramirez, Alfredo; Raybould, Rachel; Redon, Richard; Reinders, Marcel J T; Richard, Anne-Claire; Riedel-Heller, Steffi G; Rivadeneira, Fernando; van Rooij, Jeroen G J; Rousseau, Stéphane; Ryan, Natalie S; Sanchez-Juan, Pascual; Schellenberg, Gerard D; Scheltens, Philip; Schott, Jonathan M; Seshadri, Sudha; Sie, Daoud; Sims, Rebecca; Sistermans, Erik A; Sorbi, Sandro; van Swieten, John C; Tijms, Betty; Uitterlinden, André G; Visser, Pieter Jelle; Wagner, Michael; Wallon, David; Wang, Li-San; Williams, Julie; Yokoyama, Jennifer S; Zarea, Aline; van der Lee, Sven J; Olsen, Johan G; Hulsman, Marc; Holstege, Henne

Modeling common Alzheimer's disease with high and low polygenic risk in human iPSC: A large-scale research resource.

利用人类 iPSC 模拟具有高低多基因风险的常见阿尔茨海默病:大规模研究资源

Maguire Emily, Winston Jincy, Ellwood Sarah H, O'Donoghue Rachel, Shaw Bethany, Morales Atahualpa Castillo, Keat Samuel, Evans Alexandra, Marshall Rachel, Luckcuck Lauren, Brown Laura, Salis Elisa, Leonenko Ganna, Denning Nicola, Allen Nicholas D, Escott-Price Valentina, Webber Caleb, Taylor Philip R, Sims Rebecca, Cowley Sally A, Williams Julie, Carpanini Sarah M, Hall-Roberts Hazel

Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease

外显子组测序发现ATP8B4和ABCA1基因中的罕见有害变异是阿尔茨海默病风险因素。

Holstege, Henne; Hulsman, Marc; Charbonnier, Camille; Grenier-Boley, Benjamin; Quenez, Olivier; Grozeva, Detelina; van Rooij, Jeroen G J; Sims, Rebecca; Ahmad, Shahzad; Amin, Najaf; Norsworthy, Penny J; Dols-Icardo, Oriol; Hummerich, Holger; Kawalia, Amit; Amouyel, Philippe; Beecham, Gary W; Berr, Claudine; Bis, Joshua C; Boland, Anne; Bossù, Paola; Bouwman, Femke; Bras, Jose; Campion, Dominique; Cochran, J Nicholas; Daniele, Antonio; Dartigues, Jean-François; Debette, Stéphanie; Deleuze, Jean-François; Denning, Nicola; DeStefano, Anita L; Farrer, Lindsay A; Fernández, Maria Victoria; Fox, Nick C; Galimberti, Daniela; Genin, Emmanuelle; Gille, Johan J P; Le Guen, Yann; Guerreiro, Rita; Haines, Jonathan L; Holmes, Clive; Ikram, M Arfan; Ikram, M Kamran; Jansen, Iris E; Kraaij, Robert; Lathrop, Marc; Lemstra, Afina W; Lleó, Alberto; Luckcuck, Lauren; Mannens, Marcel M A M; Marshall, Rachel; Martin, Eden R; Masullo, Carlo; Mayeux, Richard; Mecocci, Patrizia; Meggy, Alun; Mol, Merel O; Morgan, Kevin; Myers, Richard M; Nacmias, Benedetta; Naj, Adam C; Napolioni, Valerio; Pasquier, Florence; Pastor, Pau; Pericak-Vance, Margaret A; Raybould, Rachel; Redon, Richard; Reinders, Marcel J T; Richard, Anne-Claire; Riedel-Heller, Steffi G; Rivadeneira, Fernando; Rousseau, Stéphane; Ryan, Natalie S; Saad, Salha; Sanchez-Juan, Pascual; Schellenberg, Gerard D; Scheltens, Philip; Schott, Jonathan M; Seripa, Davide; Seshadri, Sudha; Sie, Daoud; Sistermans, Erik A; Sorbi, Sandro; van Spaendonk, Resie; Spalletta, Gianfranco; Tesi, Niccolo'; Tijms, Betty; Uitterlinden, André G; van der Lee, Sven J; Visser, Pieter Jelle; Wagner, Michael; Wallon, David; Wang, Li-San; Zarea, Aline; Clarimon, Jordi; van Swieten, John C; Greicius, Michael D; Yokoyama, Jennifer S; Cruchaga, Carlos; Hardy, John; Ramirez, Alfredo; Mead, Simon; van der Flier, Wiesje M; van Duijn, Cornelia M; Williams, Julie; Nicolas, Gaël; Bellenguez, Céline; Lambert, Jean-Charles

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

对已确诊阿尔茨海默病患者的遗传荟萃分析发现了新的风险位点,并揭示了Aβ、tau蛋白、免疫和脂质加工等因素与该疾病的关联。

Kunkle, Brian W; Grenier-Boley, Benjamin; Sims, Rebecca; Bis, Joshua C; Damotte, Vincent; Naj, Adam C; Boland, Anne; Vronskaya, Maria; van der Lee, Sven J; Amlie-Wolf, Alexandre; Bellenguez, Céline; Frizatti, Aura; Chouraki, Vincent; Martin, Eden R; Sleegers, Kristel; Badarinarayan, Nandini; Jakobsdottir, Johanna; Hamilton-Nelson, Kara L; Moreno-Grau, Sonia; Olaso, Robert; Raybould, Rachel; Chen, Yuning; Kuzma, Amanda B; Hiltunen, Mikko; Morgan, Taniesha; Ahmad, Shahzad; Vardarajan, Badri N; Epelbaum, Jacques; Hoffmann, Per; Boada, Merce; Beecham, Gary W; Garnier, Jean-Guillaume; Harold, Denise; Fitzpatrick, Annette L; Valladares, Otto; Moutet, Marie-Laure; Gerrish, Amy; Smith, Albert V; Qu, Liming; Bacq, Delphine; Denning, Nicola; Jian, Xueqiu; Zhao, Yi; Del Zompo, Maria; Fox, Nick C; Choi, Seung-Hoan; Mateo, Ignacio; Hughes, Joseph T; Adams, Hieab H; Malamon, John; Sanchez-Garcia, Florentino; Patel, Yogen; Brody, Jennifer A; Dombroski, Beth A; Naranjo, Maria Candida Deniz; Daniilidou, Makrina; Eiriksdottir, Gudny; Mukherjee, Shubhabrata; Wallon, David; Uphill, James; Aspelund, Thor; Cantwell, Laura B; Garzia, Fabienne; Galimberti, Daniela; Hofer, Edith; Butkiewicz, Mariusz; Fin, Bertrand; Scarpini, Elio; Sarnowski, Chloe; Bush, Will S; Meslage, Stéphane; Kornhuber, Johannes; White, Charles C; Song, Yuenjoo; Barber, Robert C; Engelborghs, Sebastiaan; Sordon, Sabrina; Voijnovic, Dina; Adams, Perrie M; Vandenberghe, Rik; Mayhaus, Manuel; Cupples, L Adrienne; Albert, Marilyn S; De Deyn, Peter P; Gu, Wei; Himali, Jayanadra J; Beekly, Duane; Squassina, Alessio; Hartmann, Annette M; Orellana, Adelina; Blacker, Deborah; Rodriguez-Rodriguez, Eloy; Lovestone, Simon; Garcia, Melissa E; Doody, Rachelle S; Munoz-Fernadez, Carmen; Sussams, Rebecca; Lin, Honghuang; Fairchild, Thomas J; Benito, Yolanda A; Holmes, Clive; Karamujić-Čomić, Hata; Frosch, Matthew P; Thonberg, Hakan; Maier, Wolfgang; Roshchupkin, Gennady; Ghetti, Bernardino; Giedraitis, Vilmantas; Kawalia, Amit; Li, Shuo; Huebinger, Ryan M; Kilander, Lena; Moebus, Susanne; Hernández, Isabel; Kamboh, M Ilyas; Brundin, RoseMarie; Turton, James; Yang, Qiong; Katz, Mindy J; Concari, Letizia; Lord, Jenny; Beiser, Alexa S; Keene, C Dirk; Helisalmi, Seppo; Kloszewska, Iwona; Kukull, Walter A; Koivisto, Anne Maria; Lynch, Aoibhinn; Tarraga, Lluís; Larson, Eric B; Haapasalo, Annakaisa; Lawlor, Brian; Mosley, Thomas H; Lipton, Richard B; Solfrizzi, Vincenzo; Gill, Michael; Longstreth, W T Jr; Montine, Thomas J; Frisardi, Vincenza; Diez-Fairen, Monica; Rivadeneira, Fernando; Petersen, Ronald C; Deramecourt, Vincent; Alvarez, Ignacio; Salani, Francesca; Ciaramella, Antonio; Boerwinkle, Eric; Reiman, Eric M; Fievet, Nathalie; Rotter, Jerome I; Reisch, Joan S; Hanon, Olivier; Cupidi, Chiara; Andre Uitterlinden, A G; Royall, Donald R; Dufouil, Carole; Maletta, Raffaele Giovanni; de Rojas, Itziar; Sano, Mary; Brice, Alexis; Cecchetti, Roberta; George-Hyslop, Peter St; Ritchie, Karen; Tsolaki, Magda; Tsuang, Debby W; Dubois, Bruno; Craig, David; Wu, Chuang-Kuo; Soininen, Hilkka; Avramidou, Despoina; Albin, Roger L; Fratiglioni, Laura; Germanou, Antonia; Apostolova, Liana G; Keller, Lina; Koutroumani, Maria; Arnold, Steven E; Panza, Francesco; Gkatzima, Olymbia; Asthana, Sanjay; Hannequin, Didier; Whitehead, Patrice; Atwood, Craig S; Caffarra, Paolo; Hampel, Harald; Quintela, Inés; Carracedo, Ángel; Lannfelt, Lars; Rubinsztein, David C; Barnes, Lisa L; Pasquier, Florence; Frölich, Lutz; Barral, Sandra; McGuinness, Bernadette; Beach, Thomas G; Johnston, Janet A; Becker, James T; Passmore, Peter; Bigio, Eileen H; Schott, Jonathan M; Bird, Thomas D; Warren, Jason D; Boeve, Bradley F; Lupton, Michelle K; Bowen, James D; Proitsi, Petra; Boxer, Adam; Powell, John F; Burke, James R; Kauwe, John S K; Burns, Jeffrey M; Mancuso, Michelangelo; Buxbaum, Joseph D; Bonuccelli, Ubaldo; Cairns, Nigel J; McQuillin, Andrew; Cao, Chuanhai; Livingston, Gill; Carlson, Chris S; Bass, Nicholas J; Carlsson, Cynthia M; Hardy, John; Carney, Regina M; Bras, Jose; Carrasquillo, Minerva M; Guerreiro, Rita; Allen, Mariet; Chui, Helena C; Fisher, Elizabeth; Masullo, Carlo; Crocco, Elizabeth A; DeCarli, Charles; Bisceglio, Gina; Dick, Malcolm; Ma, Li; Duara, Ranjan; Graff-Radford, Neill R; Evans, Denis A; Hodges, Angela; Faber, Kelley M; Scherer, Martin; Fallon, Kenneth B; Riemenschneider, Matthias; Fardo, David W; Heun, Reinhard; Farlow, Martin R; Kölsch, Heike; Ferris, Steven; Leber, Markus; Foroud, Tatiana M; Heuser, Isabella; Galasko, Douglas R; Giegling, Ina; Gearing, Marla; Hüll, Michael; Geschwind, Daniel H; Gilbert, John R; Morris, John; Green, Robert C; Mayo, Kevin; Growdon, John H; Feulner, Thomas; Hamilton, Ronald L; Harrell, Lindy E; Drichel, Dmitriy; Honig, Lawrence S; Cushion, Thomas D; Huentelman, Matthew J; Hollingworth, Paul; Hulette, Christine M; Hyman, Bradley T; Marshall, Rachel; Jarvik, Gail P; Meggy, Alun; Abner, Erin; Menzies, Georgina E; Jin, Lee-Way; Leonenko, Ganna; Real, Luis M; Jun, Gyungah R; Baldwin, Clinton T; Grozeva, Detelina; Karydas, Anna; Russo, Giancarlo; Kaye, Jeffrey A; Kim, Ronald; Jessen, Frank; Kowall, Neil W; Vellas, Bruno; Kramer, Joel H; Vardy, Emma; LaFerla, Frank M; Jöckel, Karl-Heinz; Lah, James J; Dichgans, Martin; Leverenz, James B; Mann, David; Levey, Allan I; Pickering-Brown, Stuart; Lieberman, Andrew P; Klopp, Norman; Lunetta, Kathryn L; Wichmann, H-Erich; Lyketsos, Constantine G; Morgan, Kevin; Marson, Daniel C; Brown, Kristelle; Martiniuk, Frank; Medway, Christopher; Mash, Deborah C; Nöthen, Markus M; Masliah, Eliezer; Hooper, Nigel M; McCormick, Wayne C; Daniele, Antonio; McCurry, Susan M; Bayer, Anthony; McDavid, Andrew N; Gallacher, John; McKee, Ann C; van den Bussche, Hendrik; Mesulam, Marsel; Brayne, Carol; Miller, Bruce L; Riedel-Heller, Steffi; Miller, Carol A; Miller, Joshua W; Al-Chalabi, Ammar; Morris, John C; Shaw, Christopher E; Myers, Amanda J; Wiltfang, Jens; O'Bryant, Sid; Olichney, John M; Alvarez, Victoria; Parisi, Joseph E; Singleton, Andrew B; Paulson, Henry L; Collinge, John; Perry, William R; Mead, Simon; Peskind, Elaine; Cribbs, David H; Rossor, Martin; Pierce, Aimee; Ryan, Natalie S; Poon, Wayne W; Nacmias, Benedetta; Potter, Huntington; Sorbi, Sandro; Quinn, Joseph F; Sacchinelli, Eleonora; Raj, Ashok; Spalletta, Gianfranco; Raskind, Murray; Caltagirone, Carlo; Bossù, Paola; Orfei, Maria Donata; Reisberg, Barry; Clarke, Robert; Reitz, Christiane; Smith, A David; Ringman, John M; Warden, Donald; Roberson, Erik D; Wilcock, Gordon; Rogaeva, Ekaterina; Bruni, Amalia Cecilia; Rosen, Howard J; Gallo, Maura; Rosenberg, Roger N; Ben-Shlomo, Yoav; Sager, Mark A; Mecocci, Patrizia; Saykin, Andrew J; Pastor, Pau; Cuccaro, Michael L; Vance, Jeffery M; Schneider, Julie A; Schneider, Lori S; Slifer, Susan; Seeley, William W; Smith, Amanda G; Sonnen, Joshua A; Spina, Salvatore; Stern, Robert A; Swerdlow, Russell H; Tang, Mitchell; Tanzi, Rudolph E; Trojanowski, John Q; Troncoso, Juan C; Van Deerlin, Vivianna M; Van Eldik, Linda J; Vinters, Harry V; Vonsattel, Jean Paul; Weintraub, Sandra; Welsh-Bohmer, Kathleen A; Wilhelmsen, Kirk C; Williamson, Jennifer; Wingo, Thomas S; Woltjer, Randall L; Wright, Clinton B; Yu, Chang-En; Yu, Lei; Saba, Yasaman; Pilotto, Alberto; Bullido, Maria J; Peters, Oliver; Crane, Paul K; Bennett, David; Bosco, Paola; Coto, Eliecer; Boccardi, Virginia; De Jager, Phil L; Lleo, Alberto; Warner, Nick; Lopez, Oscar L; Ingelsson, Martin; Deloukas, Panagiotis; Cruchaga, Carlos; Graff, Caroline; Gwilliam, Rhian; Fornage, Myriam; Goate, Alison M; Sanchez-Juan, Pascual; Kehoe, Patrick G; Amin, Najaf; Ertekin-Taner, Nilifur; Berr, Claudine; Debette, Stéphanie; Love, Seth; Launer, Lenore J; Younkin, Steven G; Dartigues, Jean-Francois; Corcoran, Chris; Ikram, M Arfan; Dickson, Dennis W; Nicolas, Gael; Campion, Dominique; Tschanz, JoAnn; Schmidt, Helena; Hakonarson, Hakon; Clarimon, Jordi; Munger, Ron; Schmidt, Reinhold; Farrer, Lindsay A; Van Broeckhoven, Christine; C O'Donovan, Michael; DeStefano, Anita L; Jones, Lesley; Haines, Jonathan L; Deleuze, Jean-Francois; Owen, Michael J; Gudnason, Vilmundur; Mayeux, Richard; Escott-Price, Valentina; Psaty, Bruce M; Ramirez, Alfredo; Wang, Li-San; Ruiz, Agustin; van Duijn, Cornelia M; Holmans, Peter A; Seshadri, Sudha; Williams, Julie; Amouyel, Phillippe; Schellenberg, Gerard D; Lambert, Jean-Charles; Pericak-Vance, Margaret A

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

作者更正:对已确诊阿尔茨海默病患者的遗传荟萃分析发现了新的风险位点,并指出Aβ、tau蛋白、免疫和脂质加工与该疾病相关。

Kunkle, Brian W; Grenier-Boley, Benjamin; Sims, Rebecca; Bis, Joshua C; Damotte, Vincent; Naj, Adam C; Boland, Anne; Vronskaya, Maria; van der Lee, Sven J; Amlie-Wolf, Alexandre; Bellenguez, Céline; Frizatti, Aura; Chouraki, Vincent; Martin, Eden R; Sleegers, Kristel; Badarinarayan, Nandini; Jakobsdottir, Johanna; Hamilton-Nelson, Kara L; Moreno-Grau, Sonia; Olaso, Robert; Raybould, Rachel; Chen, Yuning; Kuzma, Amanda B; Hiltunen, Mikko; Morgan, Taniesha; Ahmad, Shahzad; Vardarajan, Badri N; Epelbaum, Jacques; Hoffmann, Per; Boada, Merce; Beecham, Gary W; Garnier, Jean-Guillaume; Harold, Denise; Fitzpatrick, Annette L; Valladares, Otto; Moutet, Marie-Laure; Gerrish, Amy; Smith, Albert V; Qu, Liming; Bacq, Delphine; Denning, Nicola; Jian, Xueqiu; Zhao, Yi; Del Zompo, Maria; Fox, Nick C; Choi, Seung-Hoan; Mateo, Ignacio; Hughes, Joseph T; Adams, Hieab H; Malamon, John; Sanchez-Garcia, Florentino; Patel, Yogen; Brody, Jennifer A; Dombroski, Beth A; Naranjo, Maria Candida Deniz; Daniilidou, Makrina; Eiriksdottir, Gudny; Mukherjee, Shubhabrata; Wallon, David; Uphill, James; Aspelund, Thor; Cantwell, Laura B; Garzia, Fabienne; Galimberti, Daniela; Hofer, Edith; Butkiewicz, Mariusz; Fin, Bertrand; Scarpini, Elio; Sarnowski, Chloe; Bush, Will S; Meslage, Stéphane; Kornhuber, Johannes; White, Charles C; Song, Yuenjoo; Barber, Robert C; Engelborghs, Sebastiaan; Sordon, Sabrina; Voijnovic, Dina; Adams, Perrie M; Vandenberghe, Rik; Mayhaus, Manuel; Cupples, L Adrienne; Albert, Marilyn S; De Deyn, Peter P; Gu, Wei; Himali, Jayanadra J; Beekly, Duane; Squassina, Alessio; Hartmann, Annette M; Orellana, Adelina; Blacker, Deborah; Rodriguez-Rodriguez, Eloy; Lovestone, Simon; Garcia, Melissa E; Doody, Rachelle S; Munoz-Fernadez, Carmen; Sussams, Rebecca; Lin, Honghuang; Fairchild, Thomas J; Benito, Yolanda A; Holmes, Clive; Karamujić-Čomić, Hata; Frosch, Matthew P; Thonberg, Hakan; Maier, Wolfgang; Roshchupkin, Gennady; Ghetti, Bernardino; Giedraitis, Vilmantas; Kawalia, Amit; Li, Shuo; Huebinger, Ryan M; Kilander, Lena; Moebus, Susanne; Hernández, Isabel; Kamboh, M Ilyas; Brundin, RoseMarie; Turton, James; Yang, Qiong; Katz, Mindy J; Concari, Letizia; Lord, Jenny; Beiser, Alexa S; Keene, C Dirk; Helisalmi, Seppo; Kloszewska, Iwona; Kukull, Walter A; Koivisto, Anne Maria; Lynch, Aoibhinn; Tarraga, Lluís; Larson, Eric B; Haapasalo, Annakaisa; Lawlor, Brian; Mosley, Thomas H; Lipton, Richard B; Solfrizzi, Vincenzo; Gill, Michael; Longstreth, W T Jr; Montine, Thomas J; Frisardi, Vincenza; Diez-Fairen, Monica; Rivadeneira, Fernando; Petersen, Ronald C; Deramecourt, Vincent; Alvarez, Ignacio; Salani, Francesca; Ciaramella, Antonio; Boerwinkle, Eric; Reiman, Eric M; Fievet, Nathalie; Rotter, Jerome I; Reisch, Joan S; Hanon, Olivier; Cupidi, Chiara; Uitterlinden, A G Andre; Royall, Donald R; Dufouil, Carole; Maletta, Raffaele Giovanni; de Rojas, Itziar; Sano, Mary; Brice, Alexis; Cecchetti, Roberta; George-Hyslop, Peter St; Ritchie, Karen; Tsolaki, Magda; Tsuang, Debby W; Dubois, Bruno; Craig, David; Wu, Chuang-Kuo; Soininen, Hilkka; Avramidou, Despoina; Albin, Roger L; Fratiglioni, Laura; Germanou, Antonia; Apostolova, Liana G; Keller, Lina; Koutroumani, Maria; Arnold, Steven E; Panza, Francesco; Gkatzima, Olymbia; Asthana, Sanjay; Hannequin, Didier; Whitehead, Patrice; Atwood, Craig S; Caffarra, Paolo; Hampel, Harald; Quintela, Inés; Carracedo, Ángel; Lannfelt, Lars; Rubinsztein, David C; Barnes, Lisa L; Pasquier, Florence; Frölich, Lutz; Barral, Sandra; McGuinness, Bernadette; Beach, Thomas G; Johnston, Janet A; Becker, James T; Passmore, Peter; Bigio, Eileen H; Schott, Jonathan M; Bird, Thomas D; Warren, Jason D; Boeve, Bradley F; Lupton, Michelle K; Bowen, James D; Proitsi, Petra; Boxer, Adam; Powell, John F; Burke, James R; Kauwe, John S K; Burns, Jeffrey M; Mancuso, Michelangelo; Buxbaum, Joseph D; Bonuccelli, Ubaldo; Cairns, Nigel J; McQuillin, Andrew; Cao, Chuanhai; Livingston, Gill; Carlson, Chris S; Bass, Nicholas J; Carlsson, Cynthia M; Hardy, John; Carney, Regina M; Bras, Jose; Carrasquillo, Minerva M; Guerreiro, Rita; Allen, Mariet; Chui, Helena C; Fisher, Elizabeth; Masullo, Carlo; Crocco, Elizabeth A; DeCarli, Charles; Bisceglio, Gina; Dick, Malcolm; Ma, Li; Duara, Ranjan; Graff-Radford, Neill R; Evans, Denis A; Hodges, Angela; Faber, Kelley M; Scherer, Martin; Fallon, Kenneth B; Riemenschneider, Matthias; Fardo, David W; Heun, Reinhard; Farlow, Martin R; Kölsch, Heike; Ferris, Steven; Leber, Markus; Foroud, Tatiana M; Heuser, Isabella; Galasko, Douglas R; Giegling, Ina; Gearing, Marla; Hüll, Michael; Geschwind, Daniel H; Gilbert, John R; Morris, John; Green, Robert C; Mayo, Kevin; Growdon, John H; Feulner, Thomas; Hamilton, Ronald L; Harrell, Lindy E; Drichel, Dmitriy; Honig, Lawrence S; Cushion, Thomas D; Huentelman, Matthew J; Hollingworth, Paul; Hulette, Christine M; Hyman, Bradley T; Marshall, Rachel; Jarvik, Gail P; Meggy, Alun; Abner, Erin; Menzies, Georgina E; Jin, Lee-Way; Leonenko, Ganna; Real, Luis M; Jun, Gyungah R; Baldwin, Clinton T; Grozeva, Detelina; Karydas, Anna; Russo, Giancarlo; Kaye, Jeffrey A; Kim, Ronald; Jessen, Frank; Kowall, Neil W; Vellas, Bruno; Kramer, Joel H; Vardy, Emma; LaFerla, Frank M; Jöckel, Karl-Heinz; Lah, James J; Dichgans, Martin; Leverenz, James B; Mann, David; Levey, Allan I; Pickering-Brown, Stuart; Lieberman, Andrew P; Klopp, Norman; Lunetta, Kathryn L; Wichmann, H-Erich; Lyketsos, Constantine G; Morgan, Kevin; Marson, Daniel C; Brown, Kristelle; Martiniuk, Frank; Medway, Christopher; Mash, Deborah C; Nöthen, Markus M; Masliah, Eliezer; Hooper, Nigel M; McCormick, Wayne C; Daniele, Antonio; McCurry, Susan M; Bayer, Anthony; McDavid, Andrew N; Gallacher, John; McKee, Ann C; van den Bussche, Hendrik; Mesulam, Marsel; Brayne, Carol; Miller, Bruce L; Riedel-Heller, Steffi; Miller, Carol A; Miller, Joshua W; Al-Chalabi, Ammar; Morris, John C; Shaw, Christopher E; Myers, Amanda J; Wiltfang, Jens; O'Bryant, Sid; Olichney, John M; Alvarez, Victoria; Parisi, Joseph E; Singleton, Andrew B; Paulson, Henry L; Collinge, John; Perry, William R; Mead, Simon; Peskind, Elaine; Cribbs, David H; Rossor, Martin; Pierce, Aimee; Ryan, Natalie S; Poon, Wayne W; Nacmias, Benedetta; Potter, Huntington; Sorbi, Sandro; Quinn, Joseph F; Sacchinelli, Eleonora; Raj, Ashok; Spalletta, Gianfranco; Raskind, Murray; Caltagirone, Carlo; Bossù, Paola; Orfei, Maria Donata; Reisberg, Barry; Clarke, Robert; Reitz, Christiane; Smith, A David; Ringman, John M; Warden, Donald; Roberson, Erik D; Wilcock, Gordon; Rogaeva, Ekaterina; Bruni, Amalia Cecilia; Rosen, Howard J; Gallo, Maura; Rosenberg, Roger N; Ben-Shlomo, Yoav; Sager, Mark A; Mecocci, Patrizia; Saykin, Andrew J; Pastor, Pau; Cuccaro, Michael L; Vance, Jeffery M; Schneider, Julie A; Schneider, Lori S; Slifer, Susan; Seeley, William W; Smith, Amanda G; Sonnen, Joshua A; Spina, Salvatore; Stern, Robert A; Swerdlow, Russell H; Tang, Mitchell; Tanzi, Rudolph E; Trojanowski, John Q; Troncoso, Juan C; Van Deerlin, Vivianna M; Van Eldik, Linda J; Vinters, Harry V; Vonsattel, Jean Paul; Weintraub, Sandra; Welsh-Bohmer, Kathleen A; Wilhelmsen, Kirk C; Williamson, Jennifer; Wingo, Thomas S; Woltjer, Randall L; Wright, Clinton B; Yu, Chang-En; Yu, Lei; Saba, Yasaman; Pilotto, Alberto; Bullido, Maria J; Peters, Oliver; Crane, Paul K; Bennett, David; Bosco, Paola; Coto, Eliecer; Boccardi, Virginia; De Jager, Phil L; Lleo, Alberto; Warner, Nick; Lopez, Oscar L; Ingelsson, Martin; Deloukas, Panagiotis; Cruchaga, Carlos; Graff, Caroline; Gwilliam, Rhian; Fornage, Myriam; Goate, Alison M; Sanchez-Juan, Pascual; Kehoe, Patrick G; Amin, Najaf; Ertekin-Taner, Nilifur; Berr, Claudine; Debette, Stéphanie; Love, Seth; Launer, Lenore J; Younkin, Steven G; Dartigues, Jean-Francois; Corcoran, Chris; Ikram, M Arfan; Dickson, Dennis W; Nicolas, Gael; Campion, Dominique; Tschanz, JoAnn; Schmidt, Helena; Hakonarson, Hakon; Clarimon, Jordi; Munger, Ron; Schmidt, Reinhold; Farrer, Lindsay A; Van Broeckhoven, Christine; O'Donovan, Michael C; DeStefano, Anita L; Jones, Lesley; Haines, Jonathan L; Deleuze, Jean-Francois; Owen, Michael J; Gudnason, Vilmundur; Mayeux, Richard; Escott-Price, Valentina; Psaty, Bruce M; Ramirez, Alfredo; Wang, Li-San; Ruiz, Agustin; van Duijn, Cornelia M; Holmans, Peter A; Seshadri, Sudha; Williams, Julie; Amouyel, Phillippe; Schellenberg, Gerard D; Lambert, Jean-Charles; Pericak-Vance, Margaret A

ApoE4 lowers age at onset in patients with frontotemporal dementia and tauopathy independent of amyloid-β copathology

ApoE4 可降低额颞叶痴呆和 tau 蛋白病患者的发病年龄,且与淀粉样蛋白-β 共病理无关。

Koriath, Carolin; Lashley, Tammaryn; Taylor, William; Druyeh, Ronald; Dimitriadis, Athanasios; Denning, Nicola; Williams, Julie; Warren, Jason D; Fox, Nick C; Schott, Jonathan M; Rowe, James B; Collinge, John; Rohrer, Jonathan D; Mead, Simon

Creating a platform for collaborative genomic research

创建一个合作基因组研究平台

AlMatar, Ranim; Al-Haqan, Asmaa; Abdullah, Israa; Waheedi, Salah; Bansod, Smita; Ragha, Lata; Smithson, Mark; Frost, James; Williams, Julie; Simms, Rebecca; Majounie, Elisa; Kitchen, Christine; Badarinarayan, Nandini; Moreton, Andrew; Denning, Nicola; Bannister, Christian

Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease

全基因组分析发现了两种新的阿尔茨海默病易感基因

Escott-Price, Valentina; Bellenguez, Céline; Wang, Li-San; Choi, Seung-Hoan; Harold, Denise; Jones, Lesley; Holmans, Peter; Gerrish, Amy; Vedernikov, Alexey; Richards, Alexander; DeStefano, Anita L; Lambert, Jean-Charles; Ibrahim-Verbaas, Carla A; Naj, Adam C; Sims, Rebecca; Jun, Gyungah; Bis, Joshua C; Beecham, Gary W; Grenier-Boley, Benjamin; Russo, Giancarlo; Thornton-Wells, Tricia A; Denning, Nicola; Smith, Albert V; Chouraki, Vincent; Thomas, Charlene; Ikram, M Arfan; Zelenika, Diana; Vardarajan, Badri N; Kamatani, Yoichiro; Lin, Chiao-Feng; Schmidt, Helena; Kunkle, Brian; Dunstan, Melanie L; Vronskaya, Maria; Johnson, Andrew D; Ruiz, Agustin; Bihoreau, Marie-Thérèse; Reitz, Christiane; Pasquier, Florence; Hollingworth, Paul; Hanon, Olivier; Fitzpatrick, Annette L; Buxbaum, Joseph D; Campion, Dominique; Crane, Paul K; Baldwin, Clinton; Becker, Tim; Gudnason, Vilmundur; Cruchaga, Carlos; Craig, David; Amin, Najaf; Berr, Claudine; Lopez, Oscar L; De Jager, Philip L; Deramecourt, Vincent; Johnston, Janet A; Evans, Denis; Lovestone, Simon; Letenneur, Luc; Hernández, Isabel; Rubinsztein, David C; Eiriksdottir, Gudny; Sleegers, Kristel; Goate, Alison M; Fiévet, Nathalie; Huentelman, Matthew J; Gill, Michael; Brown, Kristelle; Kamboh, M Ilyas; Keller, Lina; Barberger-Gateau, Pascale; McGuinness, Bernadette; Larson, Eric B; Myers, Amanda J; Dufouil, Carole; Todd, Stephen; Wallon, David; Love, Seth; Rogaeva, Ekaterina; Gallacher, John; George-Hyslop, Peter St; Clarimon, Jordi; Lleo, Alberto; Bayer, Anthony; Tsuang, Debby W; Yu, Lei; Tsolaki, Magda; Bossù, Paola; Spalletta, Gianfranco; Proitsi, Petra; Collinge, John; Sorbi, Sandro; Garcia, Florentino Sanchez; Fox, Nick C; Hardy, John; Naranjo, Maria Candida Deniz; Bosco, Paolo; Clarke, Robert; Brayne, Carol; Galimberti, Daniela; Scarpini, Elio; Bonuccelli, Ubaldo; Mancuso, Michelangelo; Siciliano, Gabriele; Moebus, Susanne; Mecocci, Patrizia; Zompo, Maria Del; Maier, Wolfgang; Hampel, Harald; Pilotto, Alberto; Frank-García, Ana; Panza, Francesco; Solfrizzi, Vincenzo; Caffarra, Paolo; Nacmias, Benedetta; Perry, William; Mayhaus, Manuel; Lannfelt, Lars; Hakonarson, Hakon; Pichler, Sabrina; Carrasquillo, Minerva M; Ingelsson, Martin; Beekly, Duane; Alvarez, Victoria; Zou, Fanggeng; Valladares, Otto; Younkin, Steven G; Coto, Eliecer; Hamilton-Nelson, Kara L; Gu, Wei; Razquin, Cristina; Pastor, Pau; Mateo, Ignacio; Owen, Michael J; Faber, Kelley M; Jonsson, Palmi V; Combarros, Onofre; O'Donovan, Michael C; Cantwell, Laura B; Soininen, Hilkka; Blacker, Deborah; Mead, Simon; Mosley, Thomas H Jr; Bennett, David A; Harris, Tamara B; Fratiglioni, Laura; Holmes, Clive; de Bruijn, Renee F A G; Passmore, Peter; Montine, Thomas J; Bettens, Karolien; Rotter, Jerome I; Brice, Alexis; Morgan, Kevin; Foroud, Tatiana M; Kukull, Walter A; Hannequin, Didier; Powell, John F; Nalls, Michael A; Ritchie, Karen; Lunetta, Kathryn L; Kauwe, John S K; Boerwinkle, Eric; Riemenschneider, Matthias; Boada, Mercè; Hiltunen, Mikko; Martin, Eden R; Schmidt, Reinhold; Rujescu, Dan; Dartigues, Jean-François; Mayeux, Richard; Tzourio, Christophe; Hofman, Albert; Nöthen, Markus M; Graff, Caroline; Psaty, Bruce M; Haines, Jonathan L; Lathrop, Mark; Pericak-Vance, Margaret A; Launer, Lenore J; Van Broeckhoven, Christine; Farrer, Lindsay A; van Duijn, Cornelia M; Ramirez, Alfredo; Seshadri, Sudha; Schellenberg, Gerard D; Amouyel, Philippe; Williams, Julie