日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genetic loss of CHD1 regulates distinct histone post-translational modifications in the development of castration-resistant prostate cancer

CHD1基因缺失调控去势抵抗性前列腺癌发展过程中不同的组蛋白翻译后修饰

Purohit, Tanaya A; Gawdzik, Joseph; Armstrong, Eric A; Yang, Bing; Schultz, Zachery; Bahr, Kayla; Do, Truman J; Machhi, Rehaan; Sardeson, Sean; Rizvi, Mohammad; Nakada, Sarah A; Singh, Anupama; Esbona, Karla; Huang, Wei; Roskes, Marjorie L; Khurana, Ekta; Lewis, Peter W; Denu, John M; Jarrard, David F

Depletion of individual dietary amino acids induce distinct metabolic and chromatin states

膳食中特定氨基酸的缺乏会诱导不同的代谢和染色质状态。

Haws, Spencer A; Liu, Yang; Green, Cara L; Chaiyakul, Krittisak; Mishra, Pragyan; Babygirija, Reji; Armstrong, Eric A; Mehendale, Anusha T; Ong, Irene M; Lamming, Dudley W; Denu, John M

A needed nomenclature for nucleosomes

核小体命名法的必要性

Keogh, Michael-Christopher; Almouzni, Genevieve; Andrews, Andrew J; Armache, Karim-Jean; Arrowsmith, Cheryl H; Baek, Sung Hee; Bedford, Mark T; Bernstein, Emily; Côté, Jacques; David, Yael; Denu, John M; Fierz, Beat; Garcia, Benjamin A; Glass, Karen C; Gozani, Or; Helin, Kristian; Henikoff, Steven; Jensen, Ole N; Josefowicz, Steven Z; Kelleher, Neil L; Kutateladze, Tatiana G; Lindner, Herbert H; Lu, Chao; Luger, Karolin; Mallick, Parag; Musselman, Catherine A; Muir, Tom W; Paša-Tolić, Ljiljana; Schneider, Robert; Shi, Xiaobing; Shi, Yang; Sidoli, Simone; Smith, Lloyd M; Tyler, Jessica K; Wolberger, Cynthia; Workman, Jerry L; Strahl, Brian D; Young, Nicolas L

Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease.

在阿尔茨海默病 3xTg 小鼠模型中,禁食是实现热量限制诸多益处的必要条件

Babygirija Reji, Han Jessica H, Sonsalla Michelle M, Matoska Ryan, Calubag Mariah F, Green Cara L, Tobon Anna, Yeh Chung-Yang, Vertein Diana, Schlorf Sophia, Illiano Julia, Liu Yang, Grunow Isaac, Rigby Michael J, Puglielli Luigi, Harris David A, Denu John M, Lamming Dudley W

H2A.Z deposition by the SWR complex is stimulated by polyadenine DNA sequences in nucleosomes.

核小体中的聚腺嘌呤 DNA 序列可刺激 SWR 复合物沉积 H2A.Z

Converso Cynthia, Pierrakeas Leonidas, Chan Lirong, Chowdhury Shalvi, de Onis Emily, Kuznetsov Vyacheslav I, Denu John M, Luk Ed

Histone-modifying enzymes as drivers and therapeutic targets in androgen-resistant prostate cancer

组蛋白修饰酶作为雄激素抵抗性前列腺癌的驱动因素和治疗靶点

Purohit, Tanaya A; Bahr, Kayla; Yang, Bing; Schultz, Zachery; Lewis, Peter W; Denu, John M; Jarrard, David F

Gut microbiota-derived metabolite trimethylamine N-oxide alters the host epigenome through inhibition of S-adenosylhomocysteine hydrolase

肠道菌群代谢产物三甲胺N-氧化物通过抑制S-腺苷高半胱氨酸水解酶来改变宿主表观基因组。

Han, Jessica H; Rey, Federico E; Denu, John M

Individual dietary amino acid restrictions induce distinct metabolic and chromatin states

个体膳食氨基酸限制会诱导不同的代谢和染色质状态。

Haws, Spencer A; Liu, Yang; Green, Cara L; Chaiyakul, Krittisak; Mishra, Pragyan; Babygirija, Reji; Armstrong, Eric A; Mehendale, Anusha T; Ong, Irene M; Lamming, Dudley W; Denu, John M

Acss2 Deletion Reveals Functional Versatility via Tissue-Specific Roles in Transcriptional Regulation

Acss2 缺失揭示了其通过在转录调控中发挥组织特异性作用而展现出的功能多样性

Vasudevan, Narayanan Puthillathu; Soni, Dharmendra K; Moffett, John R; Krishnan, Jishnu K S; Appu, Abhilash P; Ghoshal, Sarani; Arun, Peethambaran; Denu, John M; Flagg, Thomas P; Biswas, Roopa; Namboodiri, Aryan M

Metabolism in the Midwest: research from the Midwest Aging Consortium at the 49(th) Annual Meeting of the American Aging Association

中西部地区的代谢:来自中西部老龄化联盟的研究成果,发表于美国老龄化协会第49届年会

Murphy, Michaela E; Narasimhan, Akilavalli; Adrian, Alexis; Kumar, Ankur; Green, Cara L; Soto-Palma, Carolina; Henpita, Chathurika; Camell, Christina; Morrow, Christopher S; Yeh, Chung-Yang; Richardson, Claire E; Hill, Cristal M; Moore, Darcie L; Lamming, Dudley W; McGregor, Eric R; Simmons, Heather A; Pak, Heidi H; Bai, Hua; Denu, John M; Clark, Josef; Simcox, Judith; Chittimalli, Kishore; Dahlquist, Korbyn; Lee, Kyoo-A; Calubag, Mariah; Bouska, Mark; Yousefzadeh, Matthew J; Sonsalla, Michelle; Babygirija, Reji; Yuan, Rong; Tsuji, Tadataka; Rhoads, Timothy; Menon, Vinal; Jarajapu, Yagna Pr; Zhu, Yun