日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Tetramerization of the DNA mismatch repair protein MutS enhances daughter strand incision preferentially in the vicinity of replication errors

DNA错配修复蛋白MutS的四聚化增强了子链在复制错误附近的切口形成。

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2025.110881
Mardenborough, Yannicka; van Genderen, Romano M; Laffeber, Charlie; de Koning, Kelly D A; Friedhoff, Peter; Kanaar, Roland; Depken, Martin; Lebbink, Joyce H G
发表日期：2025
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A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent

组装后的构象变化使SARS-CoV-2聚合酶具备延伸能力

期刊:
影响因子:
doi:10.1101/2025.01.10.632299
Klein, Misha; Das, Arnab; Bera, Subhas C; Anderson, Thomas K; Kocincova, Dana; Lee, Hery W; Wang, Bing; Papini, Flavia S; Marecki, John C; Arnold, Jamie J; Cameron, Craig E; Raney, Kevin D; Artsimovitch, Irina; Götte, Mathias; Kirchdoerfer, Robert N; Depken, Martin; Dulin, David
SARS-CoV-2
发表日期：2025
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Live-cell imaging reveals the trade-off between target search flexibility and efficiency for Cas9 and Cas12a

活细胞成像揭示了Cas9和Cas12a靶标搜索灵活性和效率之间的权衡

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkae283
Olivi, Lorenzo; Bagchus, Cleo; Pool, Victor; Bekkering, Ezra; Speckner, Konstantin; Offerhaus, Hidde; Wu, Wen Y; Depken, Martin; Martens, Koen J A; Staals, Raymond H J; Hohlbein, Johannes
细胞生物学
LCI
发表日期：2024
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Mechanism of assembly of an elongation-competent SARS-CoV-2 replication transcription complex

SARS-CoV-2 复制转录复合物延伸能力的组装机制

期刊:Jove-Journal of Visualized Experiments
影响因子:1
doi:10.3791/4182
Brinkman, Eva K; Schipper, Kira; Bongaerts, Nadine; Voges, Mathias J; Abate, Alessandro; Wahl, S Aljoscha; Klein, Misha; Bera, Subhas C; Anderson, Thomas K; Wang, Bing; Papini, Flavia S; Arnold, Jamie J; Cameron, Craig E; Depken, Martin; Kirchdoerfer, Robert N; Artsimovitch, Irina; Dulin, David
SARS-CoV-2
发表日期：2023
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Quantitative parameters of bacterial RNA polymerase open-complex formation, stabilization and disruption on a consensus promoter

细菌 RNA 聚合酶开放复合物在共识启动子上的形成、稳定和破坏的定量参数

期刊:Nucleic Acids Research
影响因子:16.6
doi:10.1093/nar/gkac560
Subhas C Bera, Pim P B America, Santeri Maatsola, Mona Seifert, Eugeniu Ostrofet, Jelmer Cnossen, Monika Spermann, Flávia S Papini, Martin Depken, Anssi M Malinen, David Dulin
微生物学
发表日期：2022
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A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity

动力学模型预测SpCas9活性，改进脱靶分类，并揭示靶向保真度的物理基础

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-022-28994-2
Eslami-Mossallam, Behrouz; Klein, Misha; Smagt, Constantijn V D; Sanden, Koen V D; Jones, Stephen K Jr; Hawkins, John A; Finkelstein, Ilya J; Depken, Martin
发表日期：2022
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Systematic decomposition of sequence determinants governing CRISPR/Cas9 specificity

控制 CRISPR/Cas9 特异性的序列决定因素的系统分解

期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-022-28028-x
Rongjie Fu #, Wei He #, Jinzhuang Dou, Oscar D Villarreal, Ella Bedford, Helen Wang, Connie Hou, Liang Zhang, Yalong Wang, Dacheng Ma, Yiwen Chen, Xue Gao, Martin Depken, Han Xu
信号转导
发表日期：2022
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Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective

从单分子角度研究核苷酸类似物对 SARS-CoV-2 聚合酶的抑制

期刊:Elife
影响因子:6.4
doi:10.7554/eLife.70968
Mona Seifert #, Subhas C Bera #, Pauline van Nies, Robert N Kirchdoerfer, Ashleigh Shannon, Thi-Tuyet-Nhung Le, Xiangzhi Meng, Hongjie Xia, James M Wood, Lawrence D Harris, Flavia S Papini, Jamie J Arnold, Steven Almo, Tyler L Grove, Pei-Yong Shi, Yan Xiang, Bruno Canard, Martin Depken, Craig E Came
免疫
新冠
发表日期：2021
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Inhibition of SARS-CoV-2 polymerase by nucleotide analogs: a single molecule perspective

核苷酸类似物对 SARS-CoV-2 聚合酶的抑制：单分子视角

期刊:
影响因子:
doi:10.1101/2020.08.06.240325
Mona Seifert #, Subhas Chandra Bera #, Pauline van Nies, Robert N Kirchdoerfer, Ashleigh Shannon, Thi-Tuyet-Nhung Le, Xiangzhi Meng, Hongjie Xia, James M Wood, Lawrence D Harris, Flávia S Papini, Jamie J Arnold, Steven C Almo, Tyler L Grove, Pei-Yong Shi, Yan Xiang, Bruno Canard, Martin Depken, Crai
免疫
新冠
发表日期：2021
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Temperature controlled high-throughput magnetic tweezers show striking difference in activation energies of replicating viral RNA-dependent RNA polymerases

温控高通量磁镊显示复制病毒 RNA 依赖性 RNA 聚合酶的活化能存在显著差异

期刊:Nucleic Acids Research
影响因子:16.6
doi:10.1093/nar/gkaa233
Mona Seifert, Pauline van Nies, Flávia S Papini, Jamie J Arnold, Minna M Poranen, Craig E Cameron, Martin Depken, David Dulin
免疫
微生物学
发表日期：2020
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