日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Phase 1 clinical trial of the ataxia telangiectasia and Rad3-related inhibitor berzosertib with irinotecan in patients with advanced solid tumors (ETCTN 9938)

共济失调毛细血管扩张症和 Rad3 相关抑制剂 berzosertib 与伊立替康联合治疗晚期实体瘤患者的 1 期临床试验 (ETCTN 9938)

期刊:Cancer
影响因子:5.1
doi:10.1002/cncr.70157
Villaruz, Liza C; Jin, Jingxiao; Wang, Hong; Lee, James J; Luke, Jason J; Rhee, John C; Waqar, Saiama N; Shapiro, Geoffrey I; Cleary, James; Davar, Diwakar; Burns, Timothy F; Verma, Rashmi; Amin, Manik; Appleman, Leonard; Ciombor, Kristen K; Davis, Elizabeth J; Riess, Jonathan W; Dees, E Claire; Kim, Edward J; Cardin, Dana; Guo, Jianxia; Christner, Susan M; Deppas, Joshua; Parise, Angelina M; Schmitz, John C; Guerrouahen, Bella S; Suchko, Michael; Contreras, Alejandro; Li, Li; Ferry-Galow, Katherine V; Chang, Ting-Chia; Jiwani, Shahanawaz; Bakkenist, Christopher J; Chu, Edward; Gore, Steven D; Beumer, Jan H
发表日期：2025
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Comparative in vivo toxicology of ATR inhibitors ceralasertib, elimusertib, and berzosertib alone and in combination with ionizing radiation

ATR抑制剂ceralasertib、elimusertib和berzosertib单独使用及与电离辐射联合使用时的体内毒理学比较

期刊:Toxicology and Applied Pharmacology
影响因子:3.4
doi:10.1016/j.taap.2025.117375
Deppas, Joshua J; Kiesel, Brian F; Guo, Jianxia; Rigatti, Lora H; Latoche, Joseph D; Green, Anthony; Knizner, Paul; Clump, D Andy; Pandya, Pinakin; Vendetti, Frank P; Bakkenist, Christopher J; Beumer, Jan H
ATR
发表日期：2025
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Phase 1 studies of the indenoisoquinolines LMP776 and LMP744 in patients with solid tumors and lymphomas

针对实体瘤和淋巴瘤患者的茚并异喹啉类化合物LMP776和LMP744的I期研究

期刊:Cancer Chemotherapy and Pharmacology
影响因子:2.3
doi:10.1007/s00280-025-04778-5
O'Sullivan Coyne, Geraldine; Kummar, Shivaani; Rubinstein, Larry V; Wilsker, Deborah; Moore, Nancy; Hogu, Murielle; Piekarz, Richard; Covey, Joe; Beumer, Jan H; Ferry-Galow, Katherine V; Villaruz, Liza C; Hollingshead, Melinda G; Holleran, Julianne L; Deppas, Joshua J; Pommier, Yves; Ko, Brian; Johnson, Barry C; Parchhment, Ralph E; Ivy, Percy; Doroshow, James H; Chen, Alice P
淋巴瘤
发表日期：2025
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Phase I trial of ATR inhibitor elimusertib with FOLFIRI in advanced or metastatic gastrointestinal malignancies (ETCTN 10406)

ATR抑制剂elimusertib联合FOLFIRI治疗晚期或转移性胃肠道恶性肿瘤的I期试验（ETCTN 10406）

期刊:Cancer Chemotherapy and Pharmacology
影响因子:2.3
doi:10.1007/s00280-024-04745-6
Krishnamurthy, Anuradha; Wang, Hong; Rhee, John C; Davar, Diwakar; Moy, Ryan H; Ratner, Lee; Christner, Susan M; Holleran, Julianne L; Deppas, Joshua; Sclafani, Carina; Schmitz, John C; Gore, Steve; Chu, Edward; Bakkenist, Christopher J; Beumer, Jan H; Villaruz, Liza C
ATR
肿瘤
肿瘤免疫
发表日期：2025
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Non-linear IV pharmacokinetics of the ATR inhibitor berzosertib (M6620) in mice

ATR 抑制剂 berzosertib (M6620) 在小鼠体内的非线性 IV 药代动力学

期刊:Cancer Chemotherapy and Pharmacology
影响因子:2.7
doi:10.1007/s00280-024-04675-3
Joshua J Deppas, Brian F Kiesel, Jianxia Guo, Robert A Parise, D Andy Clump, David Z D'Argenio, Christopher J Bakkenist, Jan H Beumer
信号转导
发表日期：2024
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Deoxyuridine-rich cytoplasmic DNA antagonizes STING-dependent innate immune responses and sensitizes resistant tumors to anti-PD-L1 therapy

富含脱氧尿苷的胞质DNA拮抗STING依赖的先天免疫反应，并使耐药肿瘤对PD-L1抑制剂治疗敏感。

期刊:
影响因子:
doi:10.1101/2024.04.04.588079
Pandya, Pinakin; Vendetti, Frank P; El-Ghoubaira, Joseph; Pathak, Sudipta; Deppas, Joshua J; Jones, Reyna; Columbus, Anthony V; Zhang, Yunqi; Ivanov, Daniel; Huang, Ziyu; MacDonald, Kate M; Harding, Shane M; Buj, Raquel; Aird, Katherine M; Beumer, Jan H; Sobol, Robert W; Bakkenist, Christopher J
PD-L1
肿瘤
免疫/内分泌
肿瘤免疫
STING
发表日期：2024
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Thymidine rescues ATR kinase inhibitor-induced deoxyuridine contamination in genomic DNA, cell death, and interferon-α/β expression

胸苷可挽救ATR激酶抑制剂诱导的基因组DNA中脱氧尿苷污染、细胞死亡和干扰素-α/β表达。

期刊:Cell Reports
影响因子:7.5
doi:10.1016/j.celrep.2022.111371
Norie Sugitani ，Frank P Vendetti ，Andrew J Cipriano ，Pinakin Pandya ，Joshua J Deppas ，Tatiana N Moiseeva ，Sandra Schamus-Haynes ，Yiyang Wang ，Drake Palmer ，Hatice U Osmanbeyoglu ，Anna Bostwick ，Nathaniel W Snyder ，Yi-Nan Gong ，Katherine M Aird ，Greg M Delgoffe ，Jan H Beumer ，Christopher J Bakkenist
ATR
细胞生物学
信号转导
发表日期：2022
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Dose-dependent bioavailability, absorption-rate limited elimination, and tissue distribution of the ATR inhibitor BAY-1895344 (elimusertib) in mice

ATR 抑制剂 BAY-1895344 (elimusertib) 在小鼠体内的剂量依赖性生物利用度、吸收速率受限消除和组织分布

期刊:Cancer Chemotherapy and Pharmacology
影响因子:2.7
doi:10.1007/s00280-022-04436-0
Brian F Kiesel, Joshua J Deppas, Jianxia Guo, Robert A Parise, David A Clump, Christopher J Bakkenist, Jan H Beumer
信号转导
发表日期：2022
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