日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CRISPR-Cas9 Screening Identifies Resistance Mechanisms to KRAS Inhibition in Pancreatic Cancer

CRISPR-Cas9筛选揭示胰腺癌中KRAS抑制的耐药机制

Long, Szu-Aun; Todd, Haley; Goodhart, Grace; Chang, Wen-Hsuan; Amparo, Amber M; Bridgens, Rachel; Dilly, Julien; Park, Se Jun; Beal, Robert M; Shehadeh, Sara M; Satyadi, Megan A; Trivedi, Vidushi K; Ackermann, Sarah E; Mukherjee, Raivath; Goodwin, Craig M; Edwards, A Cole; Stalnecker, Clint A; Greis, Kenneth D; Aguirre, Andrew J; Hobbs, G Aaron; Bryant, Kirsten L; Ahmad, Syed A; Cox, Adrienne D; Der, Channing J; Waters, Andrew M

KRASG12R-Mutant Pancreatic Cancer Features Limited ERK/MAPK Transcriptional Activity and a Distinctive Tumor Microenvironment

KRASG12R突变型胰腺癌具有ERK/MAPK转录活性受限和独特的肿瘤微环境。

Burge, Rachel A; Le Roux, Ozgun; Popow, Olesja; Spadafora, Victoria K; Rajesh, Christabelle; Adair, Sara J; Bialousow, Lucas; Murphy, Cailey; Saberi, Samaneh; Vaena, Silvia G; Taquey, Margaret C; Allen, Sarah; Han, Lu; Helke, Kristi L; Sharma, Sudarshana; Ostrowski, Michael C; Guttridge, Denis C; Dincman, Toros A; Bauer, Todd W; Kashatus, David F; McFall, Thomas; Haigis, Kevin M; Hollingsworth, Michael A; Counter, Christopher M; Der, Channing J; Hobbs, G Aaron

Mutant and Wild-Type RAS Cross-talk and Stoichiometric Deficiencies Are Determinants of Sensitivity to Targeted Therapies in KRASG12R Pancreatic Ductal Adenocarcinoma.

突变型和野生型 RAS 串扰和化学计量缺陷是 KRASG12R 胰腺导管腺癌对靶向治疗敏感性的决定因素。

Kamgar Mandana, Hobbes G Aaron, Davidson Raven, Dorbin Daniel, Herrera Juliannie, Langenheim John F, Burge Rachel A, Aldakkak Mohammed, Conrardy Ryan D, Szabo Aniko, Thalji Sam Z, Mayer Bradley, Grahl Justin J, Chung Brian Y, Phan Alexandria, Thomas James P, Seo Y David, Evans Douglas B, Christians Kathleen K, Erickson Beth, Hall William A, George Ben, Tsai Susan, Lytle Nikki K, Der Channing J, Kurzrock Razelle, McFall Thomas

Oncogenic KRAS/ERK/JUNB signaling suppresses differentiation regulator GATA6 in pancreatic cancer

致癌的KRAS/ERK/JUNB信号通路抑制胰腺癌中的分化调节因子GATA6

Zhong, Zheng; Cao, Xinang; Liao, Pei-Ju; Sethi, Raman; Klomp, Jeffrey A; Stalnecker, Clint A; Chen, Jinmiao; Wan, Yue; Der, Channing J; Virshup, David M

Combination of the MTA-Cooperative PRMT5 Inhibitor BMS-986504 and KRAS Inhibitors Is an Effective Treatment Strategy for MTAP-Deleted KRAS-Mutant Pancreatic Cancer

MTA 协同 PRMT5 抑制剂 BMS-986504 与 KRAS 抑制剂联合使用是治疗 MTAP 缺失 KRAS 突变型胰腺癌的有效策略

Drizyte-Miller, Kristina; Engstrom, Lars D; Klomp, Jeffrey A; Stalnecker, Clint A; Stamey, Addison G; Taylor, Khalilah E; Roach, Mallory K; Robb, Ryan; Waters, Laura M; Calinisan, Andrew; Degan, Seamus; Chang, Wen-Hsuan; Helu, Xousaen M; Nguyen, David; Baldelli, Elisa; Pierobon, Mariaelena; Petricoin, Emanuel F; Briere, David M; Hallin, Jill; Christensen, James G; Bryant, Kirsten L; Cox, Adrienne D; Olson, Peter; Der, Channing J

Concurrent Inhibition of the RAS-MAPK Pathway and PIKfyve Is a Therapeutic Strategy for Pancreatic Cancer.

同时抑制 RAS-MAPK 通路和 PIKfyve 是胰腺癌的一种治疗策略

DeLiberty Jonathan M, Roach Mallory K, Stalnecker Clint A, Robb Ryan, Schechter Elyse G, Pieper Noah L, Taylor Khalilah E, Pita Lily M, Yang Runying, Bang Scott, Drizyte-Miller Kristina, Ackermann Sarah E, Nicewarner Peña Sheila R, Baldelli Elisa, Min Sophia M, Drewry David H, Petricoin Emanuel F 3rd, Morris John P 4th, Der Channing J, Cox Adrienne D, Bryant Kirsten L

An allele-agnostic mutant-KRAS inhibitor suppresses tumor maintenance signals and reprograms tumor immunity in pancreatic cancer

一种不依赖于特定等位基因的突变型KRAS抑制剂可抑制肿瘤维持信号并重编程胰腺癌的肿瘤免疫。

McAndrews, Kathleen M; Paradiso, Francesca; Stalnecker, Clint A; Chellakkan, Benson S; Thege, Fredrik I; Peng, David H; Moreno Diaz, Barbara A; Sugimoto, Hikaru; Patel, Sarah I; Mahadevan, Krishnan K; Kirtley, Michelle L; Wills, Danielle; Sockwell, Amari M; Fonseca, Andre Luis F; Liu, Yunhe; Rajapakshe, Kimal I; Yee, Nathaniel G; Tran, Phuong Thao; Omar, Huda Alchikh; Tedeschi, Antonio; Schischlik-Siegl, Fiorella; Boghossian, Andrew S; Rees, Matthew G; Ronan, Melissa M; Roth, Jennifer A; Rudolph, Dorothea; Aichinger, Martin; Ebner, Florian; Artemov, Artem V; Lipp, Jesse; Pisarsky, Laura; Herrmann, Valerie Laura; Park, John; Rippmann, Jörg F; Schaaf, Otmar; Chandler, Vanessa; Williams, Mariah; Deckard, Charles E; Wang, Linghua; Der, Channing J; Vellano, Christopher; Guerrero, Paola A; Heffernan, Timothy P; Kalluri, Raghu; Maitra, Anirban

KRAS: the Achilles' heel of pancreas cancer biology

KRAS:胰腺癌生物学的阿喀琉斯之踵

Drizyte-Miller, Kristina; Talabi, Taiwo; Somasundaram, Ashwin; Cox, Adrienne D; Der, Channing J

"Undruggable KRAS": druggable after all

“不可药物治疗的KRAS”:终究还是可以药物治疗的

Cox, Adrienne D; Der, Channing J

Unlocking RAS: Finding the Right Combination Is the Key

解锁 RAS:找到正确的组合是关键

Papke, Bjoern; Der, Channing J