日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

CD3ɛ Nanobody-Engineered Extracellular Vesicles Driving In Vivo Generation of TCE-secreting CAR-Ts for Solid Tumor Therapy With Memory Response and Minimal Immunogenicity.

CD3É› 纳米抗体工程化细胞外囊泡驱动体内生成分泌 TCE 的 CAR-T 细胞，用于实体瘤治疗，具有记忆反应和最小免疫原性。

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202519440
Huang Shi-Wei, Lin Yu-Chuan, Pan Chih-Ming, Chen Yeh, Shie Ming-You, Chen Cheng-Yu, Kan Kai-Wen, Chen Yi-Wen, Liu Ming-Chao, Wu Chung-Chun, Chiang Yu-Ting, Ho Huai-Ping, Lin Chen-Yu, Lin Pei-Ying, Huang Yu-Han, Rusli Steffany, Mao Wan-Yu, Huang Pei-Wen, Wang Sin-Ting, Tsai Wan-Chen, Chiu Ya-Hsu, Lin Ting-Hsun, Chiang Wan-Ling, Chang Che-Kai, Lai Zi-Lun, Chen Mei-Chih, Chiu Shao-Chih, Cho Der-Yang
细胞生物学
CD3
囊泡
发表日期：2026
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Engineering integrin αvβ8-targeted extracellular vesicles to deliver BDNF mRNA for motor recovery in spinal cord injury

构建靶向整合素αvβ8的细胞外囊泡，以递送BDNF mRNA促进脊髓损伤后的运动功能恢复

期刊:Journal of Nanobiotechnology
影响因子:12.6
doi:10.1186/s12951-026-04222-7
Shie, Ming-You; Chiu, Cheng-Di; Chen, Yeh; Lin, Yen-Hong; Yu, Min-Hua; Chiu, You-Pen; Chiu, Po-Fan; Chen, Cheng-Yu; Chen, Yi-Wen; Chen, Mei-Chih; Cho, Der-Yang
神经科学
脊髓损伤
BDNF
囊泡
细胞生物学
发表日期：2026
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Synergistic effects of ABCG2 Q141K variant in combination with alcohol consumption and male sex on gout risk in a rare-event Taiwanese cohort

ABCG2 Q141K 变异与饮酒和男性性别对台湾罕见痛风人群痛风风险的协同作用

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-026-39327-4
Lai, Zi-Lun; Hung, Yuan-Hua; Su, Yang-Di; Lin, Chia-Yu; Li, Yu-Hsiu; Chen, Chia-Yu; Cho, Der-Yang; Hsueh, Po-Ren
痛风
ABCG2
代谢
发表日期：2026
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Deciphering novel genotypic biomarkers and functional alterations in double strand break repair pathways for Parkinson's disease

解读帕金森病双链断裂修复通路中的新型基因型生物标志物和功能改变

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-026-43533-5
Chen, Chao-Hsuan; Tsai, Chia-Wen; Chang, Wen-Shin; Lu, Ming-Kuei; Cho, Der-Yang; Bau, Da-Tian
信号转导
帕金森
神经科学
发表日期：2026
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Engineering HLA-G-targeted extracellular vesicles nanoplatform for enhanced cancer therapy through precise cancer drug delivery.

构建靶向 HLA-G 的细胞外囊泡纳米平台，通过精准的癌症药物递送增强癌症治疗效果。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-66451-y
Shie Ming-You, Huang Shi-Wei, Chen Yeh, Chen Mei-Chih, Pan Chih-Ming, Chen Cheng-Yu, Lin Yen-Hong, Yu Min-Hua, Kan Kai-Wen, Chiu Shao-Chih, Ho Hui-Chun, Chen Yi-Wen, Cho Der-Yang
细胞生物学
囊泡
发表日期：2025
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Engineered extracellular vesicles-mediated curcumin delivery in brain microenvironment modulating lysosomes, mitochondria, and microglia reprogram for parkinson's disease therapy

利用工程化细胞外囊泡介导的姜黄素递送系统，在大脑微环境中调节溶酶体、线粒体和小胶质细胞的重编程，从而治疗帕金森病。

期刊:Journal of Nanobiotechnology
影响因子:12.6
doi:10.1186/s12951-025-03911-z
Shie, Ming-You; Chen, Mei-Chih; Chen, Yeh; Huang, Shi-Wei; Lin, Yen-Hong; Yu, Min-Hua; Pan, Chih-Ming; Chen, Cheng-Yu; Chen, Yi-Wen; Hsieh, Ching-Liang; Chiu, Shao-Chih; Kao, Shung-Te; Lin, Jaung-Geng; Cho, Der-Yang
胶质细胞
帕金森
神经科学
线粒体
囊泡
细胞生物学
发表日期：2025
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Lithium-doped calcium silicate scaffolds-activated M2-polarized macrophage-derived miR-145-5p-riched extracellular vesicles to enhance osteoimmunomodulation for accelerating bone regeneration

锂掺杂硅酸钙支架激活M2极化巨噬细胞来源的富含miR-145-5p的细胞外囊泡，从而增强骨免疫调节，加速骨再生

期刊:Journal of Nanobiotechnology
影响因子:12.6
doi:10.1186/s12951-025-03679-2
Kuo, Ting-You; Lin, Tsung-Li; Lin, Yen-Hong; Chen, Cheng-Yu; Cho, Der-Yang; Chen, Yi-Wen; Shie, Ming-You
巨噬细胞
细胞生物学
囊泡
巨噬细胞
免疫/内分泌
发表日期：2025
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Diversity and longitudinal records: Genetic architecture of disease associations and polygenic risk in the Taiwanese Han population

多样性和纵向记录：台湾汉族人群疾病关联和多基因风险的遗传结构

期刊:Science Advances
影响因子:12.5
doi:10.1126/sciadv.adt0539
Liu, Ting-Yuan; Lu, Hsing-Fang; Chen, Yu-Chia; Liao, Chi-Chou; Lin, Ying-Ju; Yang, Jai-Sing; Liao, Wen-Ling; Lin, Wei-De; Chen, Shih-Yin; Huang, Yu-Chuen; Lin, Wei-Yong; Liu, Yu-Huei; Hsu, Kai-Cheng; Chang, Shih-Sheng; Chen, Hong-Da; Chou, Yu-Pao; Chang, Jan-Gowth; Wang, Chung-Hsing; Chang, Chwen-Tzuei; Huang, Chung-Ming; Yeo, Kai-Jieh; Wang, Tzu-Yuan; Yeh, Chin-Chung; Chen, Jiunn-Horng; Huang, Chi-Ping; Lai, Hsueh-Chou; Chen, Rong-Hsing; Lin, Hui-Ju; Wu, Po-Yuan; Wang, Jiu-Yao; Kuo, Chin-Chi; Cho, Der-Yang; Tsai, Chang-Hai; Tsai, Fuu-Jen
发表日期：2025
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Immunomodulation effects of collagen hydrogel encapsulating extracellular vesicles derived from calcium silicate stimulated-adipose mesenchymal stem cells for diabetic healing

胶原水凝胶包裹源自硅酸钙刺激的脂肪间充质干细胞的细胞外囊泡对糖尿病治疗的免疫调节作用

期刊:Journal of Nanobiotechnology
影响因子:10.6
doi:10.1186/s12951-025-03097-4
Yen-Hong Lin #, Yeh Chen #, En-Wei Liu #, Mei-Chih Chen, Min-Hua Yu, Cheng-Yu Chen, Chia-Che Ho, Tai-Yi Hsu-Jiang, Jian-Jr Lee, Der-Yang Cho, Ming-You Shie8
免疫
糖尿病
干细胞
发表日期：2025
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Osteoimmunomodulation of astragalus-calcium silicate scaffolds-activated M2 macrophage-derived miR-218-rich exosome for enhanced bone regeneration

黄芪-硅酸钙支架激活M2巨噬细胞来源的富含miR-218的外泌体，从而增强骨再生，发挥骨免疫调节作用

期刊:Materials Today Bio
影响因子:10.2
doi:10.1016/j.mtbio.2025.102286
Chen, Cheng-Yu; Lee, Jian-Jr; Lin, Yen-Hong; Kuo, Ting-You; Cho, Der-Yang; Shie, Ming-You
巨噬细胞
外泌体
细胞生物学
巨噬细胞
免疫/内分泌
发表日期：2025
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