日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Long-acting capsid inhibitor protects macaques from repeat SHIV challenges

长效衣壳抑制剂保护恒河猴免受反复 SHIV 攻击

Samuel J Vidal #, Elena Bekerman #, Derek Hansen, Bing Lu, Kelly Wang, Judy Mwangi, William Rowe, Federico Campigotto, Jim Zheng, Darryl Kato, Abishek Chandrashekar, Julia Barrett, Shivani Patel, Huahua Wan, Tochi Anioke, Noe B Mercado, Joseph P Nkolola, Melissa J Ferguson, William J Rinaldi, Christ

Clinical targeting of HIV capsid protein with a long-acting small molecule

长效小分子药物在临床上靶向 HIV 衣壳蛋白

John O Link, Martin S Rhee, Winston C Tse, Jim Zheng, John R Somoza, William Rowe, Rebecca Begley, Anna Chiu, Andrew Mulato, Derek Hansen, Eric Singer, Luong K Tsai, Rujuta A Bam, Chien-Hung Chou, Eda Canales, Gediminas Brizgys, Jennifer R Zhang, Jiayao Li, Michael Graupe, Philip Morganelli, Qi Liu,

A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model

一种高效长效小分子 HIV-1 衣壳抑制剂,在人源化小鼠模型中有效

Stephen R Yant, Andrew Mulato, Derek Hansen, Winston C Tse, Anita Niedziela-Majka, Jennifer R Zhang, George J Stepan, Debi Jin, Melanie H Wong, Jill M Perreira, Eric Singer, Giuseppe A Papalia, Eric Y Hu, Jim Zheng, Bing Lu, Scott D Schroeder, Kevin Chou, Shekeba Ahmadyar, Albert Liclican, Helen Yu,

TLR7 Agonist GS-9620 Is a Potent Inhibitor of Acute HIV-1 Infection in Human Peripheral Blood Mononuclear Cells

TLR7 激动剂 GS-9620 是人类外周血单核细胞急性 HIV-1 感染的有效抑制剂

Rujuta A Bam, Derek Hansen, Alivelu Irrinki, Andrew Mulato, Gregg S Jones, Joseph Hesselgesser, Christian R Frey, Tomas Cihlar, Stephen R Yant

Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile

比克替拉韦 (GS-9883) 的抗病毒活性,这是一种新型强效 HIV-1 整合酶链转移抑制剂,具有改进的抗药性

Manuel Tsiang, Gregg S Jones, Joshua Goldsmith, Andrew Mulato, Derek Hansen, Elaine Kan, Luong Tsai, Rujuta A Bam, George Stepan, Kirsten M Stray, Anita Niedziela-Majka, Stephen R Yant, Helen Yu, George Kukolj, Tomas Cihlar, Scott E Lazerwith, Kirsten L White, Haolun Jin

Inhibition of Janus kinase signaling during controlled mechanical ventilation prevents ventilation-induced diaphragm dysfunction

在控制机械通气期间抑制 Janus 激酶信号可预防通气引起的膈肌功能障碍

Ira J Smith, Guillermo L Godinez, Baljit K Singh, Kelly M McCaughey, Raniel R Alcantara, Tarikere Gururaja, Melissa S Ho, Henry N Nguyen, Annabelle M Friera, Kathy A White, John R McLaughlin, Derek Hansen, Jason M Romero, Kristen A Baltgalvis, Mark D Claypool, Wei Li, Wayne Lang, George C Yam, Marin

Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice

高脂饮食喂养的小鼠的运动表现和外周血管功能不全随着 AMPK 激活而改善

Kristen A Baltgalvis, Kathy White, Wei Li, Mark D Claypool, Wayne Lang, Raniel Alcantara, Baljit K Singh, Annabelle M Friera, John McLaughlin, Derek Hansen, Kelly McCaughey, Henry Nguyen, Ira J Smith, Guillermo Godinez, Simon J Shaw, Dane Goff, Rajinder Singh, Vadim Markovtsov, Tian-Qiang Sun, Yonch