Derrick R Witcher相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Ucenprubart is an agonistic antibody to CD200R with the potential to treat inflammatory skin disease: preclinical development and a phase 1 clinical study

Ucenprubart 是一种 CD200R 激动性抗体，具有治疗炎症性皮肤病的潜力：临床前开发和 I 期临床研究

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-025-59147-w

Anja Koester ，Derrick R Witcher ，Mark Lee ，Stephen J Demarest ，Scott Potter ，Katie Werle ，Scott Bauer ，Diana Ruiz ，Laurent Malherbe ，Josh Poorbaugh ，Andrew Glasebrook ，Christoph Preuss ，Gourab Datta ，Ziqiao Wang ，Jack Knorr ，David Manner ，Dipak Patel ，Carsten Schmitz ，Paul Klekotka ，Ajay Nirula

发表日期：2025

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The Therapeutic Monoclonal Antibody Bamlanivimab Does Not Enhance SARS-CoV-2 Infection by FcR-Mediated Mechanisms

治疗性单克隆抗体 Bamlanivimab 不会通过 FcR 介导的机制增强 SARS-CoV-2 感染

期刊:Pathogens

影响因子:3.3

doi:10.3390/pathogens12121408

Robert W Cross, Christopher M Wiethoff, Patricia Brown-Augsburger, Shawn Berens, Jamie Blackbourne, Ling Liu, Xiaohua Wu, Jonathan Tetreault, Carter Dodd, Ramtin Sina, Derrick R Witcher, Deanna Newcomb, Denzil Frost, Angela Wilcox, Viktoriya Borisevich, Krystle N Agans, Courtney Woolsey, Abhishek N

发表日期：2023

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Influence of physiochemical properties on the subcutaneous absorption and bioavailability of monoclonal antibodies

理化性质对单克隆抗体皮下吸收和生物利用度的影响

影响因子:5.6

doi:10.1080/19420862.2020.1770028

Amita Datta-Mannan, Selina Estwick, Chen Zhou, Hiuwan Choi, Nicole E Douglass, Derrick R Witcher, Jirong Lu, Catherine Beidler, Rohn Millican

发表日期：2020

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Discovery and characterization of a neutralizing pan-ELR+CXC chemokine monoclonal antibody

中和泛 ELR+CXC 趋化因子单克隆抗体的发现和表征

影响因子:5.6

doi:10.1080/19420862.2020.1831880

Jeffrey S Boyles, Catherine B Beidler, Beth A Strifler, Daniel S Girard, Zhanna Druzina, Jim D Durbin, Michelle L Swearingen, Linda N Lee, Kristine Kikly, Sudhakar Chintharlapalli, Derrick R Witcher

发表日期：2020

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Targeting the hepcidin-ferroportin pathway in anaemia of chronic kidney disease

针对慢性肾病贫血的铁调素-铁转运蛋白通路

期刊:British Journal of Clinical Pharmacology

影响因子:3.1

doi:10.1111/bcp.13877

Matthew Sheetz, Philip Barrington, Sophie Callies, Paul H Berg, Juliet McColm, Thomas Marbury, Brian Decker, Gregory L Dyas, Stephanie M E Truhlar, Robert Benschop, Donmienne Leung, Jolene Berg, Derrick R Witcher

发表日期：2019

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FcγRIIIa-dependent IFN-γ release in whole blood assay is predictive of therapeutic IgG1 antibodies safety

全血测定 FcγRIIIa 依赖性 IFN-γ 释放可预测治疗性 IgG1 抗体的安全性

影响因子:5.6

doi:10.1080/19420862.2018.1474996

Nada S Alakhras, Jiabin Qiu, Guilherme V Rocha, Derrick R Witcher, Anja Koester, Jinsam You, David A Schaer, Rikke B Holmgaard, Kyla Driscoll, Jeffrey A Willy, Laurent P Malherbe

发表日期：2018

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Role of TGF-alpha in the progression of diabetic kidney disease

TGF-α在糖尿病肾病进展中的作用

期刊:American Journal of Physiology-Renal Physiology

影响因子:3.7

doi:10.1152/ajprenal.00443.2016

Josef G Heuer, Shannon M Harlan, Derek D Yang, Dianna L Jaqua, Jeffrey S Boyles, Jonathan M Wilson, Kathleen M Heinz-Taheny, John M Sullivan, Tao Wei, Hui-Rong Qian, Derrick R Witcher, Matthew D Breyer

发表日期：2017

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Structural basis of selectivity and neutralizing activity of a TGFα/epiregulin specific antibody

TGFα/上皮调节蛋白特异性抗体的选择性和中和活性的结构基础

期刊:Protein Science

影响因子:4.5

doi:10.1002/pro.3023

Jeffrey S Boyles, Shane Atwell, Zhanna Druzina, Josef G Heuer, Derrick R Witcher

发表日期：2016

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Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics

在不影响 pI 的情况下平衡人源化 mAb 互补决定区的电荷可减少非特异性结合并改善药代动力学

影响因子:5.6

doi:10.1080/19420862.2015.1016696

Amita Datta-Mannan, Arunkumar Thangaraju, Donmienne Leung, Ying Tang, Derrick R Witcher, Jirong Lu, Victor J Wroblewski

发表日期：2015

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The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies

非特异性结合、靶标介导的清除和 FcRn 相互作用对人源化抗体药代动力学的影响

影响因子:5.6

doi:10.1080/19420862.2015.1075109

Amita Datta-Mannan, Jirong Lu, Derrick R Witcher, Donmienne Leung, Ying Tang, Victor J Wroblewski

发表日期：2015

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