日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Selective SIK2/SIK3 inhibition reprograms pro- and antiinflammatory pathways in myeloid cells, improving autoimmune disease outcomes

选择性抑制SIK2/SIK3可重编程髓系细胞中的促炎和抗炎通路,从而改善自身免疫性疾病的预后。

De Vos, Steve; Desroy, Nicolas; Bellaire, Susan J; Fernandes, Anna Pereira; Lavazais, Stéphanie; Merciris, Didier; Delachaume, Carole; Robin-Jagerschmidt, Catherine; Cosson, Adrien; Lazaryan, Angela; Van Osselaer, Nancy; Amantini, David; Peixoto, Christophe; Colli, Maikel L; Van Eeckhoutte, Thomas; Hakonen, Tiina; Constant, Magali; Garcia-Hernandez, Alberto; Barron, Rahul; D'Haens, Geert; Böcher, Wulf O

Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312

优化盐诱导激酶抑制剂的选择性和药代动力学特性,从而发现泛 SIK 抑制剂 GLPG3312

Taouès Temal-Laib, Christophe Peixoto, Nicolas Desroy, Elsa De Lemos, Florence Bonnaterre, Natacha Bienvenu, Olivier Picolet, Eric Sartori, Denis Bucher, Miriam López-Ramos, Carlos Roca Magadán, Wendy Laenen, Thomas Flower, Patrick Mollat, Olivier Bugaud, Robert Touitou, Anna Pereira Fernandes, Step

Identification of GLPG/ABBV-2737, a Novel Class of Corrector, Which Exerts Functional Synergy With Other CFTR Modulators

鉴定出 GLPG/ABBV-2737,一种新型校正剂,可与其他 CFTR 调节剂发挥功能协同作用

Gert de Wilde, Maarten Gees, Sara Musch, Katleen Verdonck, Mia Jans, Anne-Sophie Wesse, Ashvani K Singh, Tzyh-Chang Hwang, Thierry Christophe, Mathieu Pizzonero, Steven Van der Plas, Nicolas Desroy, Marlon Cowart, Pieter Stouten, Luc Nelles, Katja Conrath