日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Preclinical development of a replication-competent vesicular stomatitis virus-based Lassa virus vaccine candidate advanced into human clinical trials

一种基于具有复制能力的疱疹性口炎病毒的拉沙病毒候选疫苗的临床前开发已进入人体临床试验阶段。

Cooper, Christopher L; Morrow, Gavin; Yuan, Maoli; Postler, Thomas S; Neal, Maxwell L; Cross, Robert W; Woolsey, Courtney; Agans, Krystle N; Borisevich, Viktoriya; McNamara, Ryan P; Atyeo, Caroline; Roy, Vicky; Germosen, Daritza; Hou, Fuxiang; Li, Shui L; Reiserova, Lucia; Choi, Yesle; Wilson, Aaron; Wagner, Denise; Wallace-Selman, Olivia; Carpov, Alexei; Geng, Fuqiang; Frederick, Deborah J; DeStefano, Joanne; Ercolini, Anne M; Enriquez, Adrian S; Hastie, Kathryn M; Ramos da Silva, Suzane; Sayeed, Eddy; Coleman, John W; Kilianski, Andrew; Alter, Galit; Saphire, Erica Ollmann; Aitchison, John D; Geisbert, Thomas W; Gupta, Swati B; Feinberg, Mark B; Parks, Christopher L

An HIV-1 Env-Antibody Complex Focuses Antibody Responses to Conserved Neutralizing Epitopes

HIV-1 Env-抗体复合物将抗体反应集中于保守的中和表位

Chen, Yajing; Wilson, Richard; O'Dell, Sijy; Guenaga, Javier; Feng, Yu; Tran, Karen; Chiang, Chi-I; Arendt, Heather E; DeStefano, Joanne; Mascola, John R; Wyatt, Richard T; Li, Yuxing

Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes

降低非中和表位暴露的稳定化 HIV-1 包膜三聚体的免疫原性

de Taeye, Steven W; Ozorowski, Gabriel; Torrents de la Peña, Alba; Guttman, Miklos; Julien, Jean-Philippe; van den Kerkhof, Tom L G M; Burger, Judith A; Pritchard, Laura K; Pugach, Pavel; Yasmeen, Anila; Crampton, Jordan; Hu, Joyce; Bontjer, Ilja; Torres, Jonathan L; Arendt, Heather; DeStefano, Joanne; Koff, Wayne C; Schuitemaker, Hanneke; Eggink, Dirk; Berkhout, Ben; Dean, Hansi; LaBranche, Celia; Crotty, Shane; Crispin, Max; Montefiori, David C; Klasse, P J; Lee, Kelly K; Moore, John P; Wilson, Ian A; Ward, Andrew B; Sanders, Rogier W

Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site.

疫苗诱导的 2 级 HIV-1 中和抗体与 CD4 结合位点附近缺乏聚糖的四级表位结合

Crooks Ema T, Tong Tommy, Chakrabarti Bimal, Narayan Kristin, Georgiev Ivelin S, Menis Sergey, Huang Xiaoxing, Kulp Daniel, Osawa Keiko, Muranaka Janelle, Stewart-Jones Guillaume, Destefano Joanne, O'Dell Sijy, LaBranche Celia, Robinson James E, Montefiori David C, McKee Krisha, Du Sean X, Doria-Rose Nicole, Kwong Peter D, Mascola John R, Zhu Ping, Schief William R, Wyatt Richard T, Whalen Robert G, Binley James M

Development of a duplex real-time RT-qPCR assay to monitor genome replication, gene expression and gene insert stability during in vivo replication of a prototype live attenuated canine distemper virus vector encoding SIV gag

开发一种双重实时RT-qPCR检测方法,用于监测编码SIV gag的原型活减毒犬瘟热病毒载体在体内复制过程中的基因组复制、基因表达和基因插入稳定性。

Coleman, John W; Wright, Kevin J; Wallace, Olivia L; Sharma, Palka; Arendt, Heather; Martinez, Jennifer; DeStefano, Joanne; Zamb, Timothy P; Zhang, Xinsheng; Parks, Christopher L

The stem of vesicular stomatitis virus G can be replaced with the HIV-1 Env membrane-proximal external region without loss of G function or membrane-proximal external region antigenic properties

水疱性口炎病毒G蛋白的茎部可被HIV-1 Env膜近端外部区域替换,而不会丧失G蛋白的功能或膜近端外部区域的抗原特性。

Lorenz, Ivo C; Nguyen, Hanh T; Kemelman, Marina; Lindsay, Ross W; Yuan, Maoli; Wright, Kevin J; Arendt, Heather; Back, Jaap Willem; DeStefano, Joanne; Hoffenberg, Simon; Morrow, Gavin; Jurgens, Christy K; Phogat, Sanjay K; Zamb, Timothy J; Parks, Christopher L

SIV antigen-specific effects on immune responses induced by vaccination with DNA electroporation and plasmid IL-12

SIV抗原特异性效应对DNA电穿孔和质粒IL-12疫苗诱导的免疫反应的影响

Lindsay, Ross W; Ouellette, Ian; Arendt, Heather E; Martinez, Jennifer; DeStefano, Joanne; Lopez, Mary; Pavlakis, George N; Chiuchiolo, Maria J; Parks, Christopher L; King, C Richter