日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identifying Phased Mutations and Complex Rearrangements in Human Prostate Cancer Cell Lines through Linked-Read Whole-Genome Sequencing

通过链接读取全基因组测序识别人类前列腺癌细胞系中的阶段性突变和复杂重排

Minh-Tam Pham, Anuj Gupta, Harshath Gupta, Ajay Vaghasia, Alyza Skaist, McKinzie A Garrison, Jonathan B Coulter, Michael C Haffner, S Lilly Zheng, Jianfeng Xu, Christina DeStefano Shields, William B Isaacs, Sarah J Wheelan, William G Nelson, Srinivasan Yegnasubramanian

Bacterial-Driven Inflammation and Mutant BRAF Expression Combine to Promote Murine Colon Tumorigenesis That Is Sensitive to Immune Checkpoint Therapy

细菌驱动的炎症和突变的 BRAF 表达相结合,促进对免疫检查点疗法敏感的小鼠结肠肿瘤发生

Christina E DeStefano Shields, James R White, Liam Chung, Alyssa Wenzel, Jessica L Hicks, Ada J Tam, June L Chan, Christine M Dejea, Hongni Fan, John Michel, Ashley R Maiuri, Shruthi Sriramkumar, Ram Podicheti, Douglas B Rusch, Hao Wang, Angelo M De Marzo, Sepideh Besharati, Robert A Anders, Stephen

Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia

多胺分解代谢酶的消融会引起浦肯野细胞损伤、神经炎症和严重的共济失调

Kamyar Zahedi, Marybeth Brooks, Sharon Barone, Negah Rahmati, Tracy Murray Stewart, Matthew Dunworth, Christina Destefano-Shields, Nupur Dasgupta, Steve Davidson, Diana M Lindquist, Christine E Fuller, Roger D Smith, John L Cleveland, Robert A Casero Jr, Manoocher Soleimani

Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria

家族性腺瘤性息肉病患者的结肠生物膜中含有致瘤细菌。

Dejea, Christine M; Fathi, Payam; Craig, John M; Boleij, Annemarie; Taddese, Rahwa; Geis, Abby L; Wu, Xinqun; DeStefano Shields, Christina E; Hechenbleikner, Elizabeth M; Huso, David L; Anders, Robert A; Giardiello, Francis M; Wick, Elizabeth C; Wang, Hao; Wu, Shaoguang; Pardoll, Drew M; Housseau, Franck; Sears, Cynthia L

Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells

脆弱拟杆菌毒素通过靶向结肠上皮细胞协调促癌炎症级联反应

Liam Chung ,Erik Thiele Orberg ,Abby L Geis ,June L Chan ,Kai Fu ,Christina E DeStefano Shields ,Christine M Dejea ,Payam Fathi ,Jie Chen ,Benjamin B Finard ,Ada J Tam ,Florencia McAllister ,Hongni Fan ,Xinqun Wu ,Sudipto Ganguly ,Andriana Lebid ,Paul Metz ,Sara W Van Meerbeke ,David L Huso ,Elizabeth C Wick ,Drew M Pardoll ,Fengyi Wan ,Shaoguang Wu ,Cynthia L Sears ,Franck Housseau

Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells

脆弱拟杆菌毒素通过靶向结肠上皮细胞协调促癌炎症级联反应

Chung, Liam; Orberg, Erik Thiele; Geis, Abby L; Chan, June L; Fu, Kai; DeStefano Shields, Christina E; Dejea, Christine M; Fathi, Payam; Chen, Jie; Finard, Benjamin B; Tam, Ada J; McAllister, Florencia; Fan, Hongni; Wu, Xinqun; Ganguly, Sudipto; Lebid, Andriana; Metz, Paul; Van Meerbeke, Sara W; Huso, David L; Wick, Elizabeth C; Pardoll, Drew M; Wan, Fengyi; Wu, Shaoguang; Sears, Cynthia L; Housseau, Franck

Distinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or Infection

亚精胺氧化酶在由上皮损伤或感染引起的结肠炎中具有独特的免疫调节作用

Gobert, Alain P; Al-Greene, Nicole T; Singh, Kshipra; Coburn, Lori A; Sierra, Johanna C; Verriere, Thomas G; Luis, Paula B; Schneider, Claus; Asim, Mohammad; Allaman, Margaret M; Barry, Daniel P; Cleveland, John L; Destefano Shields, Christina E; Casero, Robert A Jr; Washington, M Kay; Piazuelo, M Blanca; Wilson, Keith T

Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer

表观遗传疗法将MYC缺失与逆转免疫逃逸和治疗肺癌联系起来

Michael J Topper ,Michelle Vaz ,Katherine B Chiappinelli ,Christina E DeStefano Shields ,Noushin Niknafs ,Ray-Whay Chiu Yen ,Alyssa Wenzel ,Jessica Hicks ,Matthew Ballew ,Meredith Stone ,Phuoc T Tran ,Cynthia A Zahnow ,Matthew D Hellmann ,Valsamo Anagnostou ,Pamela L Strissel ,Reiner Strick ,Victor E Velculescu ,Stephen B Baylin

Mismatch Repair Proteins Initiate Epigenetic Alterations during Inflammation-Driven Tumorigenesis

错配修复蛋白在炎症驱动的肿瘤发生过程中启动表观遗传改变

Maiuri, Ashley R; Peng, Michael; Podicheti, Ram; Sriramkumar, Shruthi; Kamplain, Caitlin M; Rusch, Douglas B; DeStefano Shields, Christina E; Sears, Cynthia L; O'Hagan, Heather M

The myeloid immune signature of enterotoxigenic Bacteroides fragilis-induced murine colon tumorigenesis

产肠毒素脆弱拟杆菌诱发小鼠结肠肿瘤发生的髓系免疫特征

E Thiele Orberg, H Fan, A J Tam, C M Dejea, C E Destefano Shields, S Wu, L Chung, B B Finard, X Wu, P Fathi, S Ganguly, J Fu, D M Pardoll, C L Sears, F Housseau