日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of Coronavirus Main Protease Inhibitors with Enhanced Brain Exposure and Potent Oral Efficacy in SARS-CoV-2 and MERS Infection Models

在SARS-CoV-2和MERS感染模型中发现具有增强脑暴露和强效口服疗效的冠状病毒主要蛋白酶抑制剂

Lizzadro, Luca; Li, Jiapeng; Taha, Taha Y; Degotte, Gilles; Detomasi, Tyler C; Zapatero-Belinchon, Francisco J; Hantz, Eric R; Huang, Sijie; Matsui, Yusuke; Henderson, Will R; McCann, Jack T; Montano, Mauricio; Rosecrans, Julia; Torres Pomares, Daniel F; McGovern, Briana L; Diaz-Tapia, Randy; Benjamin, Jared; Gordon, Mary E; Suazo, Isidora D; Settineri, Nicholas S; Diallo, Amy; Krogan, Nevan J; Shoichet, Brian K; Verba, Kliment A; Albrecht, Randy; García-Sastre, Adolfo; White, Kris M; Ott, Melanie; Craik, Charles S; Renslo, Adam R

Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins.

亮氨酸氨肽酶 LyLAP 能够使溶酶体降解膜蛋白。

Jain Aakriti, Heremans Isaac, Rademaker Gilles, Detomasi Tyler C, Rohweder Peter, Anderson Dashiell, Zhang Justin, Hernandez Grace A, Gupta Suprit, von Linde Teresa, Lange Mike, Spacci Martina, Luo Jiayi, Citron Y Rose, Olzmann James A, Dawson David W, Craik Charles S, Bommer Guido, Perera Rushika M, Zoncu Roberto

Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy

基于结构的、具有高效体内疗效的高生物利用度、共价、广谱冠状病毒MPro抑制剂的发现

Tyler C Detomasi ,Gilles Degotte ,Sijie Huang ,Rahul K Suryawanshi ,Amy Diallo ,Luca Lizzadro ,Francisco J Zapatero-Belinchón ,Taha Y Taha ,Jiapeng Li ,Alicia L Richards ,Eric R Hantz ,Zain Alam ,Mauricio Montano ,Maria McCavitt-Malvido ,Rajesh Gumpena ,James R Partridge ,Galen J Correy ,Yusuke Matsui ,Annemarie F Charvat ,Isabella S Glenn ,Julia Rosecrans ,Jezrael L Revalde ,Dashiell Anderson ,Judd F Hultquist ,Michelle R Arkin ,R Jeffrey Neitz ,Danielle L Swaney ,Nevan J Krogan ,Brian K Shoichet ,Kliment A Verba ,Melanie Ott ,Adam R Renslo ,Charles S Craik

Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors

新型 SARS-CoV-2 主蛋白酶非共价和共价抑制剂的大型文库对接

Elissa A Fink, Conner Bardine, Stefan Gahbauer, Isha Singh, Tyler C Detomasi, Kris White, Shuo Gu, Xiaobo Wan, Jun Chen, Beatrice Ary, Isabella Glenn, Joseph O'Connell, Henry O'Donnell, Pavla Fajtová, Jiankun Lyu, Seth Vigneron, Nicholas J Young, Ivan S Kondratov, Arghavan Alisoltani, Lacy M Simons,

Proteases influence colony aggregation behavior in Vibrio cholerae

蛋白酶影响霍乱弧菌的菌落聚集行为

Tyler C Detomasi, Allison E Batka, Julie S Valastyan, Molly A Hydorn, Charles S Craik, Bonnie L Bassler, Michael A Marletta

Characterization of a unique polysaccharide monooxygenase from the plant pathogen Magnaporthe oryzae

植物病原菌稻瘟病菌中一种独特的多糖单加氧酶的表征

Alejandra Martinez-D'Alto, Xia Yan, Tyler C Detomasi, Richard I Sayler, William C Thomas, Nicholas J Talbot, Michael A Marletta

A Prototype Assay Multiplexing SARS-CoV-2 3CL-Protease and Angiotensin-Converting Enzyme 2 for Saliva-Based Diagnostics in COVID-19

一种多路复用 SARS-CoV-2 3CL-蛋白酶和血管紧张素转换酶 2 的原型检测方法,用于基于唾液的 COVID-19 诊断

Vallabh Suresh, Daniel A Sheik, Tyler C Detomasi, Tianqi Zhao, Theresa Zepeda, Shyam Saladi, Ummadisetti Chinna Rajesh, Kaleb Byers, Charles S Craik, Vincent Jo Davisson

A moonlighting function of a chitin polysaccharide monooxygenase, CWR-1, in Neurospora crassa allorecognition

几丁质多糖单加氧酶 CWR-1 在粗糙脉孢菌同种识别中的兼职功能

Tyler C Detomasi #, Adriana M Rico-Ramírez #, Richard I Sayler, A Pedro Gonçalves, Michael A Marletta, N Louise Glass

A dual-fluorophore sensor approach for ratiometric fluorescence imaging of potassium in living cells

一种用于活细胞中钾离子比率荧光成像的双荧光团传感器方法

Wang, Zeming; Detomasi, Tyler C; Chang, Christopher J

Substrate selectivity in starch polysaccharide monooxygenases

淀粉多糖单加氧酶的底物选择性

Van V Vu, John A Hangasky, Tyler C Detomasi, Skylar J W Henry, Son Tung Ngo, Elise A Span, Michael A Marletta