Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBP.
芳基磺酰胺 KCN1 可抑制体内神经胶质瘤的生长,并通过破坏 HIF-1α 与辅助因子 p300/CBP 的相互作用来干扰 HIF 信号传导
期刊:Clinical Cancer Research
影响因子:10.2
doi:10.1158/1078-0432.CCR-12-0861
Yin Shaoman, Kaluz Stefan, Devi Narra S, Jabbar Adnan A, de Noronha Rita G, Mun Jiyoung, Zhang Zhaobin, Boreddy Purushotham R, Wang Wei, Wang Zhibo, Abbruscato Thomas, Chen Zhengjia, Olson Jeffrey J, Zhang Ruiwen, Goodman Mark M, Nicolaou K C, Van Meir Erwin G