日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Systematic evaluation of antibody-mediated siRNA delivery using an industrial platform of THIOMAB-siRNA conjugates

使用 THIOMAB-siRNA 结合物工业平台对抗体介导的 siRNA 递送进行系统评估

Trinna L Cuellar, Dwight Barnes, Christopher Nelson, Joshua Tanguay, Shang-Fan Yu, Xiaohui Wen, Suzie J Scales, Julie Gesch, David Davis, Anja van Brabant Smith, Devin Leake, Richard Vandlen, Christian W Siebel

Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens

高通量 RNA 干扰筛选阐明新型流感疗法的宿主基因靶点

Victoria A Meliopoulos, Lauren E Andersen, Katherine F Birrer, Kaylene J Simpson, John W Lowenthal, Andrew G D Bean, John Stambas, Cameron R Stewart, S Mark Tompkins, Victor W van Beusechem, Iain Fraser, Musa Mhlanga, Samantha Barichievy, Queta Smith, Devin Leake, Jon Karpilow, Amy Buck, Ghil Jona, 

Specificity and functionality of microRNA inhibitors

microRNA 抑制剂的特异性和功能性

Barbara Robertson, Andrew B Dalby, Jon Karpilow, Anastasia Khvorova, Devin Leake, Annaleen Vermeulen

KLF6-SV1 is a novel antiapoptotic protein that targets the BH3-only protein NOXA for degradation and whose inhibition extends survival in an ovarian cancer model

KLF6-SV1 是一种新型抗凋亡蛋白,其靶向 BH3 特异性蛋白 NOXA 进行降解,抑制该蛋白可延长卵巢癌模型的生存期

Analisa Difeo, Fei Huang, Jaya Sangodkar, Esteban A Terzo, Devin Leake, Goutham Narla, John A Martignetti

Functional profiling reveals critical role for miRNA in differentiation of human mesenchymal stem cells

功能分析揭示 miRNA 在人类间充质干细胞分化中的关键作用

Angela Schoolmeesters, Teresa Eklund, Devin Leake, Annaleen Vermeulen, Queta Smith, Shelley Force Aldred, Yuriy Fedorov

Stability study of unmodified siRNA and relevance to clinical use

未修饰 siRNA 的稳定性研究及其与临床应用的相关性

Robyn P Hickerson, Alexander V Vlassov, Qian Wang, Devin Leake, Heini Ilves, Emilio Gonzalez-Gonzalez, Christopher H Contag, Brian H Johnston, Roger L Kaspar

Double-stranded regions are essential design components of potent inhibitors of RISC function

双链区域是 RISC 功能强效抑制剂的重要设计组成部分

Annaleen Vermeulen, Barbara Robertson, Andrew B Dalby, William S Marshall, Jon Karpilow, Devin Leake, Anastasia Khvorova, Scott Baskerville