日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Insights into ultra-low affinity lipase-antibody noncovalent complex binding mechanisms

深入了解超低亲和力脂肪酶-抗体非共价复合物结合机制

Elizabeth Sara Hecht, Shrenik Mehta, Aaron T Wecksler, Ben Aguilar, Nathaniel Swanson, Wilson Phung, Ananya Dubey Kelsoe, W Henry Benner, Devin Tesar, Robert F Kelley, Wendy Sandoval, Alavattam Sreedhara

An in vitro FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans

体外 FcRn 依赖性转胞吞试验作为预测评估人体抗体治疗非特异性清除率的筛选工具

Shan Chung, Van Nguyen, Yuwen Linda Lin, Julien Lafrance-Vanasse, Suzie J Scales, Kevin Lin, Rong Deng, Kathi Williams, Gizette Sperinde, Juan Jenny Li, Kai Zheng, Siddharth Sukumaran, Devin Tesar, James A Ernst, Saloumeh Fischer, Greg A Lazar, Saileta Prabhu, An Song

Protein engineering to increase the potential of a therapeutic antibody Fab for long-acting delivery to the eye

蛋白质工程可提高治疗性抗体 Fab 长效递送至眼部的潜力

Devin Tesar, Jacob Luoma, Emily A Wyatt, Catherine Shi, Whitney Shatz, Philip E Hass, Mary Mathieu, Li Yi, Jacob E Corn, Katie F Maass, Kathryn Wang, Michelle Z Dion, Nisana Andersen, Kelly M Loyet, Menno van Lookeren Campagne, Karthikan Rajagopal, Leslie Dickmann, Justin M Scheer, Robert F Kelley

Evaluating the Use of Antibody Variable Region (Fv) Charge as a Risk Assessment Tool for Predicting Typical Cynomolgus Monkey Pharmacokinetics

评估抗体可变区 (Fv) 电荷作为预测典型食蟹猴药代动力学风险评估工具的用途

Daniela Bumbaca Yadav, Vikas K Sharma, Charles Andrew Boswell, Isidro Hotzel, Devin Tesar, Yonglei Shang, Yong Ying, Saloumeh K Fischer, Jane L Grogan, Eugene Y Chiang, Konnie Urban, Sheila Ulufatu, Leslie A Khawli, Saileta Prabhu, Sean Joseph, Robert F Kelley

Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge

框架选择可通过分子电荷差异影响人源化治疗性抗体的药代动力学

Bing Li, Devin Tesar, C Andrew Boswell, Hendry S Cahaya, Anne Wong, Jianhuan Zhang, Y Gloria Meng, Charles Eigenbrot, Homer Pantua, Jinyu Diao, Sharookh B Kapadia, Rong Deng, Robert F Kelley

Charge variants in IgG1: Isolation, characterization, in vitro binding properties and pharmacokinetics in rats

IgG1 中的电荷变体:分离、表征、体外结合特性和大鼠药代动力学

Leslie A Khawli, Sirj Goswami, Ryan Hutchinson, Zephania W Kwong, Jihong Yang, Xiangdan Wang, Zhenling Yao, Alavattam Sreedhara, Tony Cano, Devin Tesar, Ihsan Nijem, David E Allison, Pin Yee Wong, Yung-Hsiang Kao, Cynthia Quan, Amita Joshi, Reed J Harris, Paul Motchnik