日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A d-Phenylalanine-Benzoxazole Derivative Reveals the Role of the Essential Enzyme Rv3603c in the Pantothenate Biosynthetic Pathway of Mycobacterium tuberculosis

d-苯丙氨酸-苯并恶唑衍生物揭示结核分枝杆菌泛酸生物合成途径中必需酶 Rv3603c 的作用

Michael J Pepi, Shibin Chacko, Gary M Marqus, Vinayak Singh, Zhe Wang, Kyle Planck, Ryan T Cullinane, Penchala N Meka, Deviprasad R Gollapalli, Thomas R Ioerger, Kyu Y Rhee, Gregory D Cuny, Helena I M Boshoff, Lizbeth Hedstrom

Expanding Benzoxazole-Based Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents

扩展基于苯并恶唑的肌苷5'-单磷酸脱氢酶(IMPDH)抑制剂的结构-活性研究,探索其作为潜在抗结核药物的潜力

Chacko, Shibin; Boshoff, Helena I M; Singh, Vinayak; Ferraris, Davide M; Gollapalli, Deviprasad R; Zhang, Minjia; Lawson, Ann P; Pepi, Michael J; Joachimiak, Andrzej; Rizzi, Menico; Mizrahi, Valerie; Cuny, Gregory D; Hedstrom, Lizbeth

A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity

细菌 IMP 脱氢酶中的新型辅因子结合模式解释了抑制剂的选择性

Magdalena Makowska-Grzyska, Youngchang Kim, Natalia Maltseva, Jerzy Osipiuk, Minyi Gu, Minjia Zhang, Kavitha Mandapati, Deviprasad R Gollapalli, Suresh Kumar Gorla, Lizbeth Hedstrom, Andrzej Joachimiak

Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity

隐孢子虫IMP脱氢酶与具有体内抗寄生虫活性的抑制剂结合的结构

Kim, Youngchang; Makowska-Grzyska, Magdalena; Gorla, Suresh Kumar; Gollapalli, Deviprasad R; Cuny, Gregory D; Joachimiak, Andrzej; Hedstrom, Lizbeth

Inhibitor mediated protein degradation

抑制剂介导的蛋白质降解

Long, Marcus J C; Gollapalli, Deviprasad R; Hedstrom, Lizbeth

Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes

辅因子迁移率决定 IMPDH 和 GMPR (β-α)8 桶酶中的反应结果

Gregory C Patton, Pål Stenmark, Deviprasad R Gollapalli, Robin Sevastik, Petri Kursula, Susanne Flodin, Herwig Schuler, Colin T Swales, Hans Eklund, Fahmi Himo, Pär Nordlund, Lizbeth Hedstrom

Specific biotinylation of IMP dehydrogenase

IMP脱氢酶的特异性生物素化

Hoefler, B Christopher; Gollapalli, Deviprasad R; Hedstrom, Lizbeth

Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases

原核生物IMP脱氢酶抑制剂选择性的结构决定因素

Gollapalli, Deviprasad R; Macpherson, Iain S; Liechti, George; Gorla, Suresh Kumar; Goldberg, Joanna B; Hedstrom, Lizbeth