日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The KRAS-regulated kinome identifies WEE1 and ERK coinhibition as a potential therapeutic strategy in KRAS-mutant pancreatic cancer

KRAS 调节的激酶组表明 WEE1 和 ERK 共同抑制是 KRAS 突变型胰腺癌的潜在治疗策略

J Nathaniel Diehl, Jennifer E Klomp, Kayla R Snare, Priya S Hibshman, Devon R Blake, Zane D Kaiser, Thomas S K Gilbert, Elisa Baldelli, Mariaelena Pierobon, Björn Papke, Runying Yang, Richard G Hodge, Naim U Rashid, Emanuel F Petricoin 3rd, Laura E Herring, Lee M Graves, Adrienne D Cox, Channing J D

Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer

应用 MYC 降解筛选确定 KRAS 突变型胰腺癌对 CDK9 抑制剂的敏感性

Devon R Blake, Angelina V Vaseva, Richard G Hodge, McKenzie P Kline, Thomas S K Gilbert, Vikas Tyagi, Daowei Huang, Gabrielle C Whiten, Jacob E Larson, Xiaodong Wang, Kenneth H Pearce, Laura E Herring, Lee M Graves, Stephen V Frye, Michael J Emanuele, Adrienne D Cox, Channing J Der

KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

MEK5-ERK5 补偿机制可拮抗 KRAS 抑制引起的 MYC 降解

Angelina V Vaseva, Devon R Blake, Thomas S K Gilbert, Serina Ng, Galen Hostetter, Salma H Azam, Irem Ozkan-Dagliyan, Prson Gautam, Kirsten L Bryant, Kenneth H Pearce, Laura E Herring, Haiyong Han, Lee M Graves, Agnieszka K Witkiewicz, Erik S Knudsen, Chad V Pecot, Naim Rashid, Peter J Houghton, Kris

Retinal cone photoreceptors require phosducin-like protein 1 for G protein complex assembly and signaling

视网膜锥体光感受器需要光传导蛋白样蛋白 1 来进行 G 蛋白复合物的组装和信号传导

Christopher M Tracy, Alexander V Kolesnikov, Devon R Blake, Ching-Kang Chen, Wolfgang Baehr, Vladimir J Kefalov, Barry M Willardson

Phosducin-like protein 1 is essential for G-protein assembly and signaling in retinal rod photoreceptors

光传导蛋白样蛋白 1 对视网膜杆状光感受器中的 G 蛋白组装和信号传导至关重要

Chun Wan J Lai, Alexander V Kolesnikov, Jeanne M Frederick, Devon R Blake, Li Jiang, Jubal S Stewart, Ching-Kang Chen, Jeffery R Barrow, Wolfgang Baehr, Vladimir J Kefalov, Barry M Willardson