VX-445 (elexacaftor) inhibits chloride secretion across human bronchial epithelial cells by directly blocking KCa3.1 channels
VX-445(依来卡托)通过直接阻断KCa3.1通道抑制人支气管上皮细胞的氯离子分泌。
期刊:PNAS Nexus
影响因子:3.8
doi:10.1093/pnasnexus/pgaf211
Kolski-Andreaco, Aaron; Balut, Corina M; Green, Matthew D; Sembrat, John; Bridges, Robert J; Singh, Ashvani K; Tse, Chris; Butterworth, Michael B; Devor, Daniel C