日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

VX-445 (elexacaftor) inhibits chloride secretion across human bronchial epithelial cells by directly blocking KCa3.1 channels

VX-445(依来卡托)通过直接阻断KCa3.1通道抑制人支气管上皮细胞的氯离子分泌。

Kolski-Andreaco, Aaron; Balut, Corina M; Green, Matthew D; Sembrat, John; Bridges, Robert J; Singh, Ashvani K; Tse, Chris; Butterworth, Michael B; Devor, Daniel C

Potentiation of BKCa channels by cystic fibrosis transmembrane conductance regulator correctors VX-445 and VX-121.

囊性纤维化跨膜电导调节剂 VX-445 和 VX-121 可增强 BKCa 通道

Kolski-Andreaco Aaron, Taiclet Stefanie, Myerburg Michael M, Sembrat John, Bridges Robert J, Straub Adam C, Wills Zachary P, Butterworth Michael B, Devor Daniel C

Trafficking of intermediate (KCa3.1) and small (KCa2.x) conductance, Ca(2+)-activated K(+) channels: a novel target for medicinal chemistry efforts?

中等电导 (KCa3.1) 和小电导 (KCa2.x) Ca(2+) 激活 K(+) 通道的转运:药物化学研究的新靶点?

Balut, Corina M; Hamilton, Kirk L; Devor, Daniel C

Basolateral membrane K+ channels in renal epithelial cells

肾上皮细胞基底外侧膜钾离子通道

Hamilton, Kirk L; Devor, Daniel C

Calcium-activated K+ channels increase cell proliferation independent of K+ conductance

钙激活的K+通道促进细胞增殖,且该过程与K+电导无关。

Millership, Joanne E; Devor, Daniel C; Hamilton, Kirk L; Balut, Corina M; Bruce, Jason I E; Fearon, Ian M

Role of ubiquitylation and USP8-dependent deubiquitylation in the endocytosis and lysosomal targeting of plasma membrane KCa3.1

泛素化和USP8依赖性去泛素化在质膜KCa3.1的内吞作用和溶酶体靶向中的作用

Balut, Corina M; Loch, Christian M; Devor, Daniel C

ESCRT-dependent targeting of plasma membrane localized KCa3.1 to the lysosomes

ESCRT依赖性靶向将KCa3.1定位于溶酶体,从而将质膜定位于溶酶体

Balut, Corina M; Gao, Yajuan; Murray, Sandra A; Thibodeau, Patrick H; Devor, Daniel C

Immunofluorescence-based assay to identify modulators of the number of plasma membrane KCa3.1 channels

利用免疫荧光法鉴定质膜KCa3.1通道数量的调节因子

Balut, Corina M; Gao, Yajuan; Luke, Cliff; Devor, Daniel C

Role of S3 and S4 transmembrane domain charged amino acids in channel biogenesis and gating of KCa2.3 and KCa3.1

S3和S4跨膜结构域带电氨基酸在KCa2.3和KCa3.1通道生物合成和门控中的作用

Gao, Yajuan; Chotoo, Cavita K; Balut, Corina M; Sun, Fei; Bailey, Mark A; Devor, Daniel C

An NH2-terminal multi-basic RKR motif is required for the ATP-dependent regulation of hIK1

hIK1 的 ATP 依赖性调控需要 NH2 末端多碱性 RKR 基序。

Jones, Heather M; Bailey, Mark A; Baty, Catherine J; Macgregor, Gordon G; Syme, Colin A; Hamilton, Kirk L; Devor, Daniel C