日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Tolerogenic nanoparticles restore the antitumor activity of recombinant immunotoxins by mitigating immunogenicity

耐受性纳米粒子通过减轻免疫原性恢复重组免疫毒素的抗肿瘤活性

Ronit Mazor, Emily M King, Masanori Onda, Nicolas Cuburu, Selamawit Addissie, Devorah Crown, Xiu-Fen Liu, Takashi Kei Kishimoto, Ira Pastan

Elimination of murine and human T-cell epitopes in recombinant immunotoxin eliminates neutralizing and anti-drug antibodies in vivo

重组免疫毒素中鼠和人 T 细胞表位的消除可消除体内的中和抗体和抗药物抗体

Ronit Mazor, Devorah Crown, Selamawit Addissie, Youjin Jang, Gilad Kaplan, Ira Pastan

A heterodimer of a VHH (variable domains of camelid heavy chain-only) antibody that inhibits anthrax toxin cell binding linked to a VHH antibody that blocks oligomer formation is highly protective in an anthrax spore challenge model

抑制炭疽毒素细胞结合的 VHH(骆驼重链可变结构域)抗体异二聚体与阻断寡聚体形成的 VHH 抗体相连,在炭疽孢子攻击模型中具有高度保护性

Mahtab Moayeri, Clinton E Leysath, Jacqueline M Tremblay, Catherine Vrentas, Devorah Crown, Stephen H Leppla, Charles B Shoemaker

Inflammasome sensor NLRP1 controls rat macrophage susceptibility to Toxoplasma gondii

炎症小体传感器 NLRP1 控制大鼠巨噬细胞对弓形虫的敏感性

Kimberly M Cirelli, Gezahegn Gorfu, Musa A Hassan, Morton Printz, Devorah Crown, Stephen H Leppla, Michael E Grigg, Jeroen P J Saeij, Mahtab Moayeri

Arsenic trioxide and other arsenical compounds inhibit the NLRP1, NLRP3, and NAIP5/NLRC4 inflammasomes

三氧化二砷和其他砷化合物抑制 NLRP1、NLRP3 和 NAIP5/NLRC4 炎症小体

Nolan K Maier, Devorah Crown, Jie Liu, Stephen H Leppla, Mahtab Moayeri

Key tissue targets responsible for anthrax-toxin-induced lethality

导致炭疽毒素致死的关键组织目标

Shihui Liu, Yi Zhang, Mahtab Moayeri, Jie Liu, Devorah Crown, Rasem J Fattah, Alexander N Wein, Zu-Xi Yu, Toren Finkel, Stephen H Leppla

Anthrax edema factor toxicity is strongly mediated by the N-end rule

炭疽水肿因子毒性主要由 N 端规则介导

Clinton E Leysath, Damilola D Phillips, Devorah Crown, Rasem J Fattah, Mahtab Moayeri, Stephen H Leppla

Mouse monoclonal antibodies to anthrax edema factor protect against infection

小鼠抗炭疽水肿因子单克隆抗体可预防感染

Clinton E Leysath, Kuang-Hua Chen, Mahtab Moayeri, Devorah Crown, Rasem Fattah, Zhaochun Chen, Suman R Das, Robert H Purcell, Stephen H Leppla

Anthrax lethal toxin activates the inflammasome in sensitive rat macrophages

炭疽致命毒素激活敏感大鼠巨噬细胞中的炎症小体

Zachary L Newman, Devorah Crown, Stephen H Leppla, Mahtab Moayeri

Novel chimpanzee/human monoclonal antibodies that neutralize anthrax lethal factor, and evidence for possible synergy with anti-protective antigen antibody

中和炭疽致死因子的新型黑猩猩/人类单克隆抗体及其与抗保护性抗原抗体可能产生协同作用的证据

Zhaochun Chen, Mahtab Moayeri, Devorah Crown, Suzanne Emerson, Inna Gorshkova, Peter Schuck, Stephen H Leppla, Robert H Purcell