日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

The Alzheimer's therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia.

阿尔茨海默病治疗药物Lecanemab通过诱导小胶质细胞中的淀粉样蛋白清除程序来减轻Aβ病理。

期刊:Nature Neuroscience
影响因子:20
doi:10.1038/s41593-025-02125-8
Albertini Giulia, Zielonka Magdalena, Cuypers Marie-Lynn, Snellinx An, Xu Ciana, Poovathingal Suresh, Wojno Marta, Davie Kristofer, van Lieshout Veerle, Craessaerts Katleen, Wolfs Leen, Pasciuto Emanuela, Jaspers Tom, Horré Katrien, Serneels Lurgarde, Fiers Mark, Dewilde Maarten, De Strooper Bart
胶质细胞
阿尔茨海默症
细胞生物学
发表日期：2026
文献求助 收藏

Phagocytes as plaque catalysts: Human macrophages generate seeding-competent Aβ42 fibrils with cross-seeding activity

吞噬细胞作为斑块催化剂：人巨噬细胞产生具有交叉播散活性的、可播散斑块的Aβ42原纤维

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2516774123
Konstantoulea, Katerina; Ramakers, Meine; Borrie, Sarah C; T'Syen, Dries; Moechars, Daan; Sliwinska, Malgorzata A; Pradhan, Brajabandhu; Albertini, Giulia; Baligács, Nóra; Tsaka, Grigoria; Houben, Bert; Fiers, Mark; Gallardo, Rodrigo; Dewilde, Maarten; Thal, Dietmar Rudolf; Willem, Michael; Neher, Jonas J; De Strooper, Bart; Rousseau, Frederic; Schymkowitz, Joost
Human
免疫/内分泌
细胞生物学
巨噬细胞
巨噬细胞
发表日期：2026
文献求助 收藏

A versatile platform for combinatorial antibody library cloning and NGS-based quality control with high accuracy

一个用于组合抗体库克隆和基于NGS的质量控制的多功能平台，具有高精度

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkaf1001
Zhang, Zhongyao; D'Hondt, Simon; Van der Kant, Rob; Hermans, Guy; Geukens, Nick; Pinheiro, Vitor Bernardes; Schymkowitz, Joost; Rousseau, Frederic; Dewilde, Maarten
发表日期：2025
文献求助 收藏

Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease.

Lecanemab 优先与阿尔茨海默病早期存在的较小聚集体结合

期刊:Alzheimers & Dementia
影响因子:11.1
doi:10.1002/alz.70086
Fertan Emre, Lam Jeff Y L, Albertini Giulia, Dewilde Maarten, Wu Yunzhao, Akingbade Oluwatomi E S, Böken Dorothea, English Elizabeth A, De Strooper Bart, Klenerman David
其它
发表日期：2025
文献求助 收藏

Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein.

通过与髓鞘少突胶质细胞糖蛋白（一种中枢神经系统特异性蛋白）的额外结合，延长抗体在大脑中的半衰期

期刊:Fluids and Barriers of the Cns
影响因子:6.2
doi:10.1186/s12987-025-00624-1
Cuypers Marie-Lynn, Jaspers Tom, Clerckx Jarne, Leekens Simon, Cawthorne Christopher, Bormans Guy, Cleeren Frederik, Geukens Nick, De Strooper Bart, Dewilde Maarten
神经科学
细胞生物学
发表日期：2025
文献求助 收藏

Neuropsychiatric symptoms and brain aging in mild cognitive impairment and early dementia: A multicenter study

轻度认知障碍和早期痴呆患者的神经精神症状与脑老化：一项多中心研究

期刊:IEEE Journal of Translational Engineering in Health and Medicine-Jtehm
影响因子:4.4
doi:10.1109/JTEHM.2020.3039043
Hiwaki, Osamu; Zelek, Wioleta M; Bevan, Ryan J; Nimo, Jacqui M; Dewilde, Maarten; De Strooper, Bart; Morgan, Bryan Paul; Sone, Daichi; Beheshti, Iman; Tagai, Kenji; Kameyama, Hiroshi; Takasaki, Emi; Kashibayashi, Tetsuo; Takahashi, Ryuichi; Ishii, Kazunari; Kanemoto, Hideki; Ikeda, Manabu; Shigeta, Masahiro; Shinagawa, Shunichiro; Kazui, Hiroaki; Sone, Daichi; Beheshti, Iman; Tagai, Kenji; Kameyama, Hiroshi; Takasaki, Emi; Kashibayashi, Tetsuo; Takahashi, Ryuichi; Ishii, Kazunari; Kanemoto, Hideki; Ikeda, Manabu; Shigeta, Masahiro; Shinagawa, Shunichiro; Kazui, Hiroaki
衰老
神经科学
发表日期：2024
文献求助 收藏

Using anti‐Aβ antibodies to modulate the multi‐pronged human microglia response to Aβ pathology

利用抗Aβ抗体调节人类小胶质细胞对Aβ病理的多方面反应

期刊:Physics in Medicine and Biology
影响因子:3.4
doi:10.1088/1361-6560/ab23cb
Wang, Yuli; Li, Yingjie; Yi, Fei; Li, Junyu; Xie, Siwei; Peng, Qiyu; Xu, Jianfeng; Albertini, Giulia; Zielonka, Magdalena; Cuypers, Marie‐Lynn; van Lieshout, Veerle; Snellinx, An; Pasciuto, Emanuela; Wolfs, Leen; Craessaerts, Katleen; Horré, Katrien; Jaspers, Tom; Fiers, Mark; Dewilde, Maarten; De Strooper, Bart
胶质细胞
细胞生物学
发表日期：2024
文献求助 收藏

Exploring the Fate of Antibody-Encoding pDNA after Intramuscular Electroporation in Mice.

探索小鼠肌肉内电穿孔后编码抗体的pDNA的命运

期刊:Pharmaceutics
影响因子:5.5
doi:10.3390/pharmaceutics15041160
Cuypers Marie-Lynn, Geukens Nick, Hollevoet Kevin, Declerck Paul, Dewilde Maarten
免疫/内分泌
发表日期：2023
文献求助 收藏

Clinically relevant dosing and pharmacokinetics of DNA-encoded antibody therapeutics in a sheep model

在绵羊模型中研究DNA编码抗体疗法的临床相关剂量和药代动力学

期刊:Frontiers in Oncology
影响因子:3.3
doi:10.3389/fonc.2022.1017612
Hollevoet, Kevin; Thomas, Debby; Compernolle, Griet; Vermeire, Giles; De Smidt, Elien; De Vleeschauwer, Stéphanie; Smith, Trevor R F; Fisher, Paul D; Dewilde, Maarten; Geukens, Nick; Declerck, Paul
发表日期：2022
文献求助 收藏