日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Neuron-targeted gene therapy rescues multiple phenotypes of STXBP1-related disorders in mice and is well tolerated in nonhuman primates.

针对神经元的基因疗法可以挽救小鼠中多种 STXBP1 相关疾病的表型,并且在非人灵长类动物中具有良好的耐受性

Aeran Rangoli, Tanenhaus Annie, Sears Sheila M S, Moerke Nathan J, Miller Adam, Artur Camille, Bouhlal Yosr, Bove Peter F, Diaz de Arce Alexander J, Shimizu Saki, Le Jason, Place Keith, Hoffelt Dixon, Amarlkhagva Tselmeg, Su Jennifer, Chen Ming, Babineau Brooke A, McLaughlin John, Soe Myat, Macdonald Warren, Lin I Winnie, Bole Dhruv, Valentine Kristen M, Hallam Elizabeth, Dhanota Puja, Liu Serena, Tan Steven A, Zhao Ben, Hosur Raghavendra, Vila Maria Candida, Poda Suresh, Belle Archana, Tagliatela Stephanie

Discovery of Potent and Selective 7-Azaindole Isoindolinone-Based PI3Kγ Inhibitors

发现高效选择性的7-氮杂吲哚异吲哚啉酮类PI3Kγ抑制剂

Miles, Dillon H; Yan, Xuelei; Thomas-Tran, Rhiannon; Fournier, Jeremy; Sharif, Ehesan U; Drew, Samuel L; Mata, Guillaume; Lawson, Kenneth V; Ginn, Elaine; Wong, Kent; Soni, Divyank; Dhanota, Puja; Shaqfeh, Stefan G; Meleza, Cesar; Chen, Ada; Pham, Amber T; Park, Timothy; Swinarski, Debbie; Banuelos, Jesus; Schindler, Ulrike; Walters, Matthew J; Walker, Nigel P; Zhao, Xiaoning; Young, Stephen W; Chen, Jie; Jin, Lixia; Leleti, Manmohan Reddy; Powers, Jay P; Jeffrey, Jenna L

Functional characterization of the cytochrome P450 monooxygenase CYP71AU87 indicates a role in marrubiin biosynthesis in the medicinal plant Marrubium vulgare

细胞色素P450单加氧酶CYP71AU87的功能表征表明其在药用植物白毛茛(Marrubium vulgare)中马鲁宾生物合成中发挥作用。

Karunanithi, Prema S; Dhanota, Puja; Addison, J Bennett; Tong, Shen; Fiehn, Oliver; Zerbe, Philipp