日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Collateral hypersensitivity between ZY19489 and piperaquine neutralizes PfCRT-mediated drug efflux and Plasmodium falciparum resistance

ZY19489 与哌喹之间的协同超敏反应可中和 PfCRT 介导的药物外排和恶性疟原虫耐药性。

Okombo, John; Ndiaye, Tolla; Qahash, Tarrick; Moura, Igor M R; Gil-Iturbe, Eva; Hagenah, Laura M; Bridgford, Jessica L; Bonatto, Vinicius; Ward, Kurt E; Yeo, Tomas; Narwal, Sunil K; Orta, Lily V; Anderson, Isla; Dhingra, Satish K; Pasaje, Charisse Flerida A; Park, Heekuk; Kim, Jonathan; Guido, Rafael V C; Angulo-Barturen, Iñigo; Niles, Jacquin C; Mancia, Filippo; Uhlemann, Anne-Catrin; Mok, Sachel; Quick, Matthias; Winzeler, Elizabeth A; Leroy, Didier; Llinás, Manuel; Thathy, Vandana; Fidock, David A

Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance.

恶性疟原虫体外系统进化揭示了耐药性的关键决定因素

Luth Madeline R, Godinez-Macias Karla P, Chen Daisy, Okombo John, Thathy Vandana, Cheng Xiu, Daggupati Sindhu, Davies Heledd, Dhingra Satish K, Economy Jan M, Edgar Rebecca C S, Gomez-Lorenzo Maria G, Istvan Eva S, Jado Juan Carlos, LaMonte Gregory M, Melillo Bruno, Mok Sachel, Narwal Sunil K, Ndiaye Tolla, Ottilie Sabine, Palomo Diaz Sara, Park Heekuk, Peña Stella, Rocamora Frances, Sakata-Kato Tomoyo, Small-Saunders Jennifer L, Summers Robert L, Tumwebaze Patrick K, Vanaerschot Manu, Xia Guoqin, Yeo Tomas, You Ashley, Gamo Francisco-Javier, Goldberg Daniel E, Lee Marcus C S, McNamara Case W, Ndiaye Daouda, Rosenthal Philip J, Schreiber Stuart L, Serra Gloria, De Siqueira-Neto Jair Lage, Skinner-Adams Tina S, Uhlemann Anne-Catrin, Kato Nobutaka, Lukens Amanda K, Wirth Dyann F, Fidock David A, Winzeler Elizabeth A

Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology

在提高适应性的选择压力下,额外的 PfCRT 突变会导致哌喹耐药性的丧失和恶性疟原虫生理的改变。

Hagenah, Laura M; Dhingra, Satish K; Small-Saunders, Jennifer L; Qahash, Tarrick; Willems, Andreas; Schindler, Kyra A; Rangel, Gabriel W; Gil-Iturbe, Eva; Kim, Jonathan; Akhundova, Emiliya; Yeo, Tomas; Okombo, John; Mancia, Filippo; Quick, Matthias; Roepe, Paul D; Llinás, Manuel; Fidock, David A

Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness.

绘制恶性疟原虫多重耐药性的基因组图谱及其对寄生虫适应性的影响

Mok Sachel, Yeo Tomas, Hong Davin, Shears Melanie J, Ross Leila S, Ward Kurt E, Dhingra Satish K, Kanai Mariko, Bridgford Jessica L, Tripathi Abhai K, Mlambo Godfree, Burkhard Anna Y, Fairhurst Kate J, Gil-Iturbe Eva, Park Heekuk, Rozenberg Felix D, Kim Jonathan, Mancia Filippo, Quick Matthias, Uhlemann Anne-Catrin, Sinnis Photini, Fidock David A

Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance

早期出现哌喹耐药性恶性疟原虫的证据及缓解耐药性的建模策略

Small-Saunders, Jennifer L; Hagenah, Laura M; Wicht, Kathryn J; Dhingra, Satish K; Deni, Ioanna; Kim, Jonathan; Vendome, Jeremie; Gil-Iturbe, Eva; Roepe, Paul D; Mehta, Monica; Mancia, Filippo; Quick, Matthias; Eppstein, Margaret J; Fidock, David A

Plasmodium falciparum resistance to piperaquine driven by PfCRT

由 PfCRT 驱动的恶性疟原虫对哌喹的耐药性

Dhingra, Satish K; Small-Saunders, Jennifer L; Ménard, Didier; Fidock, David A

Global Spread of Mutant PfCRT and Its Pleiotropic Impact on Plasmodium falciparum Multidrug Resistance and Fitness

突变型PfCRT的全球传播及其对恶性疟原虫多药耐药性和适应性的多效性影响

Dhingra, Satish K; Gabryszewski, Stanislaw J; Small-Saunders, Jennifer L; Yeo, Tomas; Henrich, Philipp P; Mok, Sachel; Fidock, David A

Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter

恶性疟原虫氯喹耐药转运蛋白调控血红蛋白代谢和细胞内离子流的证据

Lee, Andrew H; Dhingra, Satish K; Lewis, Ian A; Singh, Maneesh K; Siriwardana, Amila; Dalal, Seema; Rubiano, Kelly; Klein, Matthias S; Baska, Katelynn S; Krishna, Sanjeev; Klemba, Michael; Roepe, Paul D; Llinás, Manuel; Garcia, Celia R S; Fidock, David A

A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine

PfCRT 同工酶的变异可能导致恶性疟原虫对一线联合药物哌喹产生耐药性

Dhingra, Satish K; Redhi, Devasha; Combrinck, Jill M; Yeo, Tomas; Okombo, John; Henrich, Philipp P; Cowell, Annie N; Gupta, Purva; Stegman, Matthew L; Hoke, Jonathan M; Cooper, Roland A; Winzeler, Elizabeth; Mok, Sachel; Egan, Timothy J; Fidock, David A

Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology

赋予恶性疟原虫4-氨基喹啉类药物耐药性的适应性成本中性突变体PfCRT的进化伴随着寄生虫代谢和消化液泡生理的改变

Gabryszewski, Stanislaw J; Dhingra, Satish K; Combrinck, Jill M; Lewis, Ian A; Callaghan, Paul S; Hassett, Matthew R; Siriwardana, Amila; Henrich, Philipp P; Lee, Andrew H; Gnädig, Nina F; Musset, Lise; Llinás, Manuel; Egan, Timothy J; Roepe, Paul D; Fidock, David A