Inhibiting HSP27 activates the XBP1s/CerS1 interplay, which triggers DRP1-driven mitophagy, thereby protecting against cell death and promoting the KSHV lytic cycle in primary effusion lymphoma cells.
抑制 HSP27 可激活 XBP1s/CerS1 相互作用，从而触发 DRP1 驱动的线粒体自噬，进而保护细胞免于死亡，并促进原发性渗出性淋巴瘤细胞中的 KSHV 裂解周期。
期刊:Cell Death Discovery
影响因子:7
doi:10.1038/s41420-026-02979-2
Gonnella Roberta, Corrado Vincenzo, Scaffidi Giulio Francesco, Benedetti Rossella, Di Crosta Michele, Zarrella Roberta, Gilardini Montani Maria Saveria, Santarelli Roberta, Cirone Mara
