日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Altered Inflammatory Signature in a C9ORF72 -ALS iPSC-Derived Motor Neuron and Microglia Coculture Model.

C9ORF72 -ALS iPSC 衍生的运动神经元和小胶质细胞共培养模型中炎症特征的改变。

Gao Yujing, Brothwood Jessica L, Saini Harpreet, O'Sullivan Gregory A, Bento Carla F, McCarthy James M, Wallis Nicola G, Di Daniel Elena, Graham Brent, Tams Daniel M

Measuring neurofilament light in human plasma and cerebrospinal fluid: a comparison of five analytical immunoassays

测定人血浆和脑脊液中的神经丝轻链:五种分析免疫测定法的比较

Sheth, Udit; Harrison, Rebecca; Ferber, Kyle; Rosenbaugh, Erin G; Bevis, Amanda; Khillan, Rohini; Benatar, Michael; Bjorklund, Nicole L; Di Daniel, Elena; Harris, Glenn A; Kahn, Olga I; Liu, Yongge; Zetterberg, Henrik; Mitic, Laura L; Graham, Danielle; Gendron, Tania F

Protocol to profile spatially resolved NLRP3 inflammasome complexes using APEX2-based proximity labeling

使用基于 APEX2 的邻近标记技术分析空间分辨的 NLRP3 炎症小体复合物的方案

Zhu Liang, Andreas Damianou, Athina Grigoriou, Hannah B L Jones, Vassilena Sharlandijeva, Frederik Lassen, Iolanda Vendrell, Elena Di Daniel, Benedikt M Kessler

Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function

内源性 TFEB 和 TFE3 易位的多参数表型筛选确定了调节溶酶体功能的新型化学系列

Phillippa J Carling, Brent J Ryan, William McGuinness, Shikha Kataria, Stewart W Humble, Stefan Milde, James A Duce, Nirav Kapadia, William J Zuercher, John B Davis, Elena Di Daniel, Richard Wade-Martins

Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities

炎症小体激活受翻译后修饰相互作用的调控:新兴药物靶点机遇

Liang, Zhu; Damianou, Andreas; Di Daniel, Elena; Kessler, Benedikt M

Inhibition of the NLRP3 inflammasome by HSP90 inhibitors

HSP90 抑制剂对 NLRP3 炎症小体的抑制

Sohaib Nizami, Kanisa Arunasalam, Jack Green, James Cook, Catherine B Lawrence, Tryfon Zarganes-Tzitzikas, John B Davis, Elena Di Daniel, David Brough

Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain

降低脱落胞外域水平的抗 TREM2 scFv 的选择和结构表征

Aleksandra Szykowska, Yu Chen, Thomas B Smith, Charlotta Preger, Jingjing Yang, Dongming Qian, Shubhashish M Mukhopadhyay, Edvard Wigren, Stephen J Neame, Susanne Gräslund, Helena Persson, Peter J Atkinson, Elena Di Daniel, Emma Mead, John Wang, John B Davis, Nicola A Burgess-Brown, Alex N Bullock

A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation

表型高内涵高通量筛选可鉴定 NLRP3 炎症小体活化抑制剂

Sohaib Nizami #, Val Millar #, Kanisa Arunasalam, Tryfon Zarganes-Tzitzikas, David Brough, Gary Tresadern, Paul E Brennan, John B Davis, Daniel Ebner, Elena Di Daniel

PLCγ2 regulates TREM2 signalling and integrin-mediated adhesion and migration of human iPSC-derived macrophages

PLCγ2 调节 TREM2 信号传导和整合素介导的人类 iPSC 衍生巨噬细胞的粘附和迁移

Juliane Obst, Hazel L Hall-Roberts, Thomas B Smith, Mira Kreuzer, Lorenza Magno, Elena Di Daniel, John B Davis, Emma Mead

TBK1 and IKKε act like an OFF switch to limit NLRP3 inflammasome pathway activation

TBK1 和 IKKε 就像一个关闭开关,限制 NLRP3 炎症小体通路激活

Fabian A Fischer, Linda F M Mies, Sohaib Nizami, Eirini Pantazi, Sara Danielli, Benjamin Demarco, Michael Ohlmeyer, Michelle Sue Jann Lee, Cevayir Coban, Jonathan C Kagan, Elena Di Daniel, Jelena S Bezbradica