日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

TREM2表达水平对小胶质细胞状态、代谢能力和TREM2激动剂的疗效至关重要。

Feiten, Astrid F; Dahm, Kilian; Schlepckow, Kai; van Lengerich, Bettina; Suh, Jung H; Reifschneider, Anika; Wefers, Benedikt; Bartos, Laura M; Wind-Mark, Karin; de Weerd, Lis; Ulas, Thomas; De-Domenico, Elena; Grundschöttel, Pia; Paulusch, Stefan; Tast, Benjamin; Honda, Tamisa; Müller, Stephan A; Becker, Matthias; Khalin, Igor; Ricci, Alessio; Liesz, Arthur; Brunner, Bettina; Krenner, Claudia; Buschmann, Katrin; Nuscher, Brigitte; Spieth, Lena; Junker, Niklas; Berghoff, Stefan A; Davis, Sonnet S; Neher, Jonas J; Wurst, Wolfgang; Plesnila, Nikolaus; Lewcock, Joseph W; Simons, Mikael; Lichtenthaler, Stefan F; Di Paolo, Gilbert; Brendel, Matthias; Capell, Anja; Monroe, Kathryn M; Schultze, Joachim L; Haass, Christian

Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration and endolysosomal lipid accumulation in male PS19 mice.

诱导性删除小胶质细胞中的 DGAT1 和 2 会加剧雄性 PS19 小鼠的神经退行性变和内溶酶体脂质积累。

Tabor G Travis, Litvinchuk Alexandra, Chen Yun, Allison Austin, Sun Elizabeth W, van Lengerich Bettina, Davis Sonnet S, West Elizabeth, Schlachetzki Johannes C M, Zeng Carisa, Hu Hao, Lin Peter B, Sharma Prabal, Chen Xiaoying, Parhizkar Samira, Song Sihui, Bao Xin, Senthil Lakshita, Iyer Abhirami K, You Shih Feng, Serrano Javier Remolina, Manis Melissa, Franke Emily, Cashikar Anil G, Yuede Carla M, Suh Jung H, Karch Celeste M, Folick Andrew, Koliwad Suneil K, Farese Robert V Jr, Walther Tobias, Huang Eric J, Artyomov Maxim, Glass Christopher K, Di Paolo Gilbert, Ulrich Jason D, Holtzman David M

A Common PD-Risk GBA1 Variant Disrupts LIMP2 Interaction, Impairs Glucocerebrosidase Function, and Drives Lysosomal and Mitochondrial Dysfunction.

常见的帕金森病风险 GBA1 变异会破坏 LIMP2 相互作用,损害葡萄糖脑苷脂酶功能,并导致溶酶体和线粒体功能障碍

Davis Oliver B, Kung Jennifer E, Davis Sonnet S, Ghosh Rajarshi, Andrews Shan V, Gould Neal S, Kluss Jillian H, Thomsen Elliot, Agam Maayan, Coan John P, Maloney Michael T, Nguyen Ann H, Nguyen Hoang N, Propson Nicholas E, Lozano Edwin I, Yuan Tianao, Xa Kaitlin, Sperberg R Andres Parra, Jain Shourya, Lawrence Roger, Ullman Julie C, Balasundar Srijana, Benton H Paul, Petkovic Maja, Qerqez Ahlam N, Wang Xiang, Zhu Sha, Di Paolo Gilbert, Kariolis Mihalis S, Mahon Cathal S, Arguello Annie, Vocadlo David J, Cookson Mark R, Suh Jung H, Rougé Lionel, Henry Anastasia G

Lysosomal phospholipase A2 contributes to the biosynthesis of the atypical late endosome lipid bis(monoacylglycero)phosphate

溶酶体磷脂酶A2参与非典型晚期内体脂质双(单酰甘油)磷酸酯的生物合成。

Chen, Jacinda; Cazenave-Gassiot, Amaury; Xu, Yimeng; Piroli, Paola; Hwang, Robert Jr; DeFreitas, Laura; Chan, Robin Barry; Di Paolo, Gilbert; Nandakumar, Renu; Wenk, Markus R; Marquer, Catherine

Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice

APOE4等位基因剂量对老年小鼠内嗅皮层脂质组学特征的影响

Miranda, André Miguel; Ashok, Archana; Chan, Robin Barry; Zhou, Bowen; Xu, Yimeng; McIntire, Laura Beth; Area-Gomez, Estela; Di Paolo, Gilbert; Duff, Karen E; Oliveira, Tiago Gil; Nuriel, Tal

PLD1 promotes reactive oxygen species production in vascular smooth muscle cells and injury-induced neointima formation.

PLD1促进血管平滑肌细胞中活性氧的产生和损伤诱导的新内膜形成

Cai Ming, Wang Ziqing, Luu Thi Thu Trang, Zhang Dakai, Finke Brian, He Jingquan, Tay Li Wei Rachel, Di Paolo Gilbert, Du Guangwei

Differential lipid composition and regulation along the hippocampal longitudinal axis

海马纵轴上脂质组成和调控的差异

Miranda, André Miguel; Bravo, Francisca Vaz; Chan, Robin B; Sousa, Nuno; Di Paolo, Gilbert; Oliveira, Tiago Gil

Elevated GM3 plasma concentration in idiopathic Parkinson's disease: A lipidomic analysis

特发性帕金森病患者血浆GM3浓度升高:脂质组学分析

Chan, Robin B; Perotte, Adler J; Zhou, Bowen; Liong, Christopher; Shorr, Evan J; Marder, Karen S; Kang, Un J; Waters, Cheryl H; Levy, Oren A; Xu, Yimeng; Shim, Hong Bin; Pe'er, Itsik; Di Paolo, Gilbert; Alcalay, Roy N

Remodeling of the postsynaptic plasma membrane during neural development

神经发育过程中突触后质膜的重塑

Tulodziecka, Karolina; Diaz-Rohrer, Barbara B; Farley, Madeline M; Chan, Robin B; Di Paolo, Gilbert; Levental, Kandice R; Waxham, M Neal; Levental, Ilya

Profiling the Essential Nature of Lipid Metabolism in Asexual Blood and Gametocyte Stages of Plasmodium falciparum

分析恶性疟原虫无性血液期和配子体期脂质代谢的基本特征

Gulati, Sonia; Ekland, Eric H; Ruggles, Kelly V; Chan, Robin B; Jayabalasingham, Bamini; Zhou, Bowen; Mantel, Pierre-Yves; Lee, Marcus C S; Spottiswoode, Natasha; Coburn-Flynn, Olivia; Hjelmqvist, Daisy; Worgall, Tilla S; Marti, Matthias; Di Paolo, Gilbert; Fidock, David A