日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer

小分子靶向癌症中不依赖于GPCR的非经典G蛋白信号通路

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2213140120
Zhao, Jingyi; DiGiacomo, Vincent; Ferreras-Gutierrez, Mariola; Dastjerdi, Shiva; Ibáñez de Opakua, Alain; Park, Jong-Chan; Luebbers, Alex; Chen, Qingyan; Beeler, Aaron; Blanco, Francisco J; Garcia-Marcos, Mikel
信号转导
肿瘤
GPCR/Calcium/cAMP
肿瘤免疫
发表日期：2023
文献求助 收藏

Small-molecule targeting of GPCR-independent non-canonical G protein signaling inhibits cancer progression

靶向GPCR非依赖性非经典G蛋白信号通路的小分子可抑制癌症进展

期刊:
影响因子:
doi:10.1101/2023.02.18.529092
Zhao, Jingyi; DiGiacomo, Vincent; Ferreras-Gutierrez, Mariola; Dastjerdi, Shiva; de Opakua, Alain Ibáñez; Park, Jong-Chan; Luebbers, Alex; Chen, Qingyan; Beeler, Aaron; Blanco, Francisco J; Garcia-Marcos, Mikel
肿瘤免疫
信号转导
GPCR/Calcium/cAMP
肿瘤
发表日期：2023
文献求助 收藏

Probing the mutational landscape of regulators of G protein signaling proteins in cancer.

探究癌症中 G 蛋白信号调节蛋白的突变图谱

期刊:Science Signaling
影响因子:6.6
doi:10.1126/scisignal.aax8620
DiGiacomo Vincent, Maziarz Marcin, Luebbers Alex, Norris Jillian M, Laksono Pandu, Garcia-Marcos Mikel
肿瘤
发表日期：2020
文献求助 收藏

When Heterotrimeric G Proteins Are Not Activated by G Protein-Coupled Receptors: Structural Insights and Evolutionary Conservation

当异源三聚体G蛋白不被G蛋白偶联受体激活时：结构解析和进化保守性

期刊:Biochemistry
影响因子:3
doi:10.1021/acs.biochem.7b00845
DiGiacomo, Vincent; Marivin, Arthur; Garcia-Marcos, Mikel
信号转导
发表日期：2018
文献求助 收藏

Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif.

具有 Gα 结合和激活基序的非 GPCR 蛋白激活 Gαi 的分子机制

期刊:Nature Communications
影响因子:15.7
doi:10.1038/ncomms15163
de Opakua Alain Ibáñez, Parag-Sharma Kshitij, DiGiacomo Vincent, Merino Nekane, Leyme Anthony, Marivin Arthur, Villate Maider, Nguyen Lien T, de la Cruz-Morcillo Miguel Angel, Blanco-Canosa Juan B, Ramachandran Sekar, Baillie George S, Cerione Richard A, Blanco Francisco J, Garcia-Marcos Mikel
免疫/内分泌
发表日期：2017
文献求助 收藏

Specific inhibition of GPCR-independent G protein signaling by a rationally engineered protein

通过合理设计的蛋白质特异性抑制GPCR非依赖性G蛋白信号传导

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1707992114
Leyme, Anthony; Marivin, Arthur; Maziarz, Marcin; DiGiacomo, Vincent; Papakonstantinou, Maria P; Patel, Prachi P; Blanco-Canosa, Juan B; Walawalkar, Isha A; Rodriguez-Davila, Gonzalo; Dominguez, Isabel; Garcia-Marcos, Mikel
信号转导
GPCR/Calcium/cAMP
发表日期：2017
文献求助 收藏

The Gαi-GIV binding interface is a druggable protein-protein interaction.

Gαi-GIV 结合界面是一种可成药的蛋白质-蛋白质相互作用

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-017-08829-7
DiGiacomo Vincent, de Opakua Alain Ibáñez, Papakonstantinou Maria P, Nguyen Lien T, Merino Nekane, Blanco-Canosa Juan B, Blanco Francisco J, Garcia-Marcos Mikel
免疫/内分泌
发表日期：2017
文献求助 收藏

Looking into laminin receptor: critical discussion regarding the non-integrin 37/67-kDa laminin receptor/RPSA protein

层粘连蛋白受体研究：关于非整合素37/67 kDa层粘连蛋白受体/RPSA蛋白的关键性讨论

期刊:Biological Reviews
影响因子:11.7
doi:10.1111/brv.12170
DiGiacomo, Vincent; Meruelo, Daniel
信号转导
PSA
发表日期：2016
文献求助 收藏

Dominant-negative Gα subunits are a mechanism of dysregulated heterotrimeric G protein signaling in human disease.

显性负性 Gα 亚基是人类疾病中异源三聚体 G 蛋白信号传导失调的一种机制

期刊:Science Signaling
影响因子:6.6
doi:10.1126/scisignal.aad2429
Marivin Arthur, Leyme Anthony, Parag-Sharma Kshitij, DiGiacomo Vincent, Cheung Anthony Y, Nguyen Lien T, Dominguez Isabel, Garcia-Marcos Mikel
免疫/内分泌
Human
发表日期：2016
文献求助 收藏

Evolutionary Conservation of a GPCR-Independent Mechanism of Trimeric G Protein Activation.

GPCR非依赖性三聚体G蛋白激活机制的进化保守性

期刊:Molecular Biology and Evolution
影响因子:5.3
doi:10.1093/molbev/msv336
Coleman Brantley D, Marivin Arthur, Parag-Sharma Kshitij, DiGiacomo Vincent, Kim Seongseop, Pepper Judy S, Casler Jason, Nguyen Lien T, Koelle Michael R, Garcia-Marcos Mikel
免疫/内分泌
发表日期：2016
文献求助 收藏