日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery and characterization of canvuparatide, a once-weekly parathyroid hormone analog for the treatment of hypoparathyroidism

发现并鉴定了每周一次用于治疗甲状旁腺功能减退症的甲状旁腺激素类似物canvuparatide。

Zhang, Fa; Perez-Tilve, Diego; Allen, Matthew R; Metzger, Corinne E; Dorato, Michael A; Geiger, Mary Jane; DiMarchi, Richard D

Bile Acid Binding Resins Improve Glucagon Receptor Agonist-Mediated Weight Loss in Diet-Induced Obese Mice

胆汁酸结合树脂可改善饮食诱导肥胖小鼠中胰高血糖素受体激动剂介导的体重减轻

Kim, Teayoun; Pearson, Mackenzie J; Hong, Huixian; Nason, Shelly; Seck, Khadija; Antipenko, Jessica; Presedo, Natalie; DiMarchi, Richard; Roell, William C; Habegger, Kirk

Publisher Correction: GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice

出版商更正:GIPR激动剂和拮抗剂通过不同的机制降低雄性小鼠的体重和食物摄入量。

Gutgesell, Robert M; Khalil, Ahmed; Liskiewicz, Arkadiusz; Maity-Kumar, Gandhari; Novikoff, Aaron; Grandl, Gerald; Liskiewicz, Daniela; Coupland, Callum; Karaoglu, Ezgi; Akindehin, Seun; Castelino, Russell; Curion, Fabiola; Liu, Xue; Garcia-Caceres, Cristina; Cebrian-Serrano, Alberto; Douros, Jonathan D; Knerr, Patrick J; Finan, Brian; DiMarchi, Richard D; Sloop, Kyle W; Samms, Ricardo J; Theis, Fabian J; Tschöp, Matthias H; Müller, Timo D

GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice.

GIPR激动剂和拮抗剂通过不同的机制降低雄性小鼠的体重和食物摄入量

Gutgesell Robert M, Khalil Ahmed, Liskiewicz Arkadiusz, Maity-Kumar Gandhari, Novikoff Aaron, Grandl Gerald, Liskiewicz Daniela, Coupland Callum, Karaoglu Ezgi, Akindehin Seun, Castelino Russell, Curion Fabiola, Liu Xue, Garcia-Caceres Cristina, Cebrian-Serrano Alberto, Douros Jonathan D, Knerr Patrick J, Finan Brian, DiMarchi Richard D, Sloop Kyle W, Samms Ricardo J, Theis Fabian J, Tschöp Matthias H, Müller Timo D

Viral insulin/IGF-like peptides inhibit IGF-1 receptor signaling to enhance viral replication.

病毒胰岛素/IGF样肽抑制IGF-1受体信号传导,从而增强病毒复制。

Chuard Aurelien, Nesarajah Kalaimagal, Danazumi Khadija, Reiners Kaitlin, Zhang Fa, Levintov Lev, Lubos Marta, Žáková Lenka, Ruggera Rachel, McMenamin Sarah, Vashisth Harish, Jiráček Jiří, Dimarchi Richard, Altindis Emrah

A Novel Class of Complement 3a Receptor Agonists and Antagonists Derived from the TLQP-21 Peptide

一类源自TLQP-21肽的新型补体3a受体激动剂和拮抗剂

Rodriguez, Pedro; Pallais, Jean Pierre; He, Rongjun; Razzoli, Maria; McKee, John L; Bock, Hailey A; McCorvy, John D; Sham, Yuk Y; DiMarchi, Richard; Bartolomucci, Alessandro

Glucose-dependent insulinotropic polypeptide (GIP)

葡萄糖依赖性促胰岛素多肽(GIP)

Müller, Timo D; Adriaenssens, Alice; Ahrén, Bo; Blüher, Matthias; Birkenfeld, Andreas L; Campbell, Jonathan E; Coghlan, Matthew P; D'Alessio, David; Deacon, Carolyn F; DelPrato, Stefano; Douros, Jonathan D; Drucker, Daniel J; Figueredo Burgos, Natalie S; Flatt, Peter R; Finan, Brian; Gimeno, Ruth E; Gribble, Fiona M; Hayes, Matthew R; Hölscher, Christian; Holst, Jens J; Knerr, Patrick J; Knop, Filip K; Kusminski, Christine M; Liskiewicz, Arkadiusz; Mabilleau, Guillaume; Mowery, Stephanie A; Nauck, Michael A; Novikoff, Aaron; Reimann, Frank; Roberts, Anna G; Rosenkilde, Mette M; Samms, Ricardo J; Scherer, Philip E; Seeley, Randy J; Sloop, Kyle W; Wolfrum, Christian; Wootten, Denise; DiMarchi, Richard D; Tschöp, Matthias H

A once-daily GLP-1/GIP/glucagon receptor tri-agonist (NN1706) lowers body weight in rodents, monkeys and humans

每日一次的GLP-1/GIP/胰高血糖素受体三激动剂(NN1706)可降低啮齿动物、猴子和人类的体重。

Finan, Brian; Douros, Jonathan D; Goldwater, Ronald; Hansen, Ann Maria Kruse; Hjerpsted, Julie B; Hjøllund, Karina Rahr; Kankam, Martin K; Knerr, Patrick J; Konkar, Anish; Mowery, Stephanie A; Müller, Timo D; Nielsen, John Rømer; Nygård, Sune Boris; Perez-Tilve, Diego; Raun, Kirsten; Yang, Bin; Tschöp, Matthias H; DiMarchi, Richard D

Estrogenic activity of E2-conjugated GLP-1 is mediated by intracellular endolysosomal acidification and estrone metabolism.

E2 结合的 GLP-1 的雌激素活性是通过细胞内溶酶体酸化和雌酮代谢介导的

Coupland Callum, Sun Na, Khalil Ahmed, Karaoglu Özüm Ezgi, Liskiewicz Arkadiusz, Liskiewicz Daniela, Grandl Gerald, Akindehin Seun, Maity Gandhari, Yang Bin, Finan Brian, Knerr Patrick, Douros Jonathan D, Walch Axel, DiMarchi Richard, Tschöp Matthias H, Müller Timo D, Novikoff Aaron

MBX 2109, A Once-Weekly Parathyroid Hormone Replacement Therapy Prodrug: Phase 1, First-In-Human, Randomized Trial

MBX 2109,一种每周一次的甲状旁腺激素替代疗法前药:I期,首次人体随机试验

Carney, Patricia; Cutler, Gordon B Jr; Schneider, Kristi; Zhang, Fa; DiMarchi, Richard